http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/900
type: Biomarker
alias: CCL27
alias: ILC
alias: PESKY
alias: CTAK
alias: ESkine
alias: Small-inducible cytokine A27
alias: CTACK
alias: IL-11 Ralpha-locus chemokine
alias: small inducible cytokine subfamily A (Cys-Cys), member 27
alias: small-inducible cytokine A27
alias: ALP
alias: chemokine (C-C motif) ligand 27
alias: Cutaneous T-cell-attracting chemokine
alias: IL-11 R-alpha-locus chemokine
alias: cutaneous T-cell-attracting chemokine
alias: C-C motif chemokine 27
alias: cutaneous T-cell attracting chemokine
alias: CC chemokine ILC
alias: SCYA27
alias: ESKINE
alias: Skinkine
alias: skinkine
title: CCL27
hgnc name: CCL27
URN: urn:edrn:bmdb:biomarker:900
description: CCL27 is a member of the CC cytokine family, and is involved in immunoregulatory and inflammatory processes. CC cytokines are characterized by two adjacent cysteines. CCL27 functions as a chemotactic factor that attracts skin-associated memory T-lymphocytes. CCL27 may also play a role in mediating homing of lymphocytes to cutaneous sites. CCL27 binds specifically to chemokine receptor 10 (CCR10).
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/10850
references resource: Q9Y4X3

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/426
type: Biomarker
alias: DCC
alias: Immunoglobulin superfamily DCC subclass member 1
alias: IGDCC1
alias: netrin receptor DCC
alias: deleted in colorectal cancer protein
alias: CRC18
alias: colorectal tumor suppressor
alias: Colorectal cancer suppressor
alias: immunoglobulin superfamily DCC subclass member 1
alias: Tumor suppressor protein DCC
alias: CRCR1
alias: deleted in colorectal carcinoma
alias: tumor suppressor protein DCC
alias: colorectal cancer suppressor
alias: immunoglobulin superfamily, DCC subclass, member 1
title: DCC
hgnc name: DCC
URN: urn:edrn:bmdb:biomarker:426
description: DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/121
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/128
references resource: !/hgnc id/HGNC:2701
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P43146
references resource: NP 005206.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/919
type: Biomarker
alias: GPKOW
alias: G patch domain-containing protein 5
alias: Protein T54
alias: Protein MOS2 homolog
alias: protein MOS2 homolog
alias: GPATC5
alias: G patch domain and KOW motifs-containing protein
alias: Spp2
alias: G patch domain and KOW motifs
alias: GPATCH5
alias: T54
title: GPKOW
hgnc name: GPKOW
URN: urn:edrn:bmdb:biomarker:919
description: GPKOW is a a putative RNA-binding protein containing G-patch and KOW (Kyprides, Ouzounis, Woese) domains. GPKOW interacts directly with protein kinase A and protein kinase X and is also found associated with the spliceosome.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/27238
references resource: Q92917

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/378
type: Biomarker
alias: GPR65
alias: Q8IYL9
alias: hTDAG8
alias: T-cell death-associated gene 8 protein
alias: psychosine receptor
alias: G-protein coupled receptor 65
alias: G protein-coupled receptor 65
alias: TDAG8
title: GPR65
hgnc name: GPR65
URN: urn:edrn:bmdb:biomarker:378
description: GPR65, a member of the G-protein coupled receptor 1 family, is a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. GPR65 may have a role in activation-induced cell death or differentiation of T-cells. It is expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8477
references resource: Q8IYL9

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/952
type: Biomarker
alias: SRP54
alias: signal recognition particle 54kD
alias: signal recognition particle 54kDa
alias: signal recognition particle 54 kDa protein
title: SRP54
hgnc name: SRP54
URN: urn:edrn:bmdb:biomarker:952
description: SRP54, or signal recognition particle 54kDa, contains a 7S RNA molecule of 300 nucleotides and six protein subunits. SRP54 binds to the signal sequence of presecretory proteins as they emerge from the ribosomes and transfers them to a translocating chain-associating membrane protein.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6729
references resource: P61011

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/928
type: Biomarker
alias: MAP2K1
alias: MAPKK 1
alias: protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
alias: dual specificity mitogen-activated protein kinase kinase 1
alias: MEK1
alias: MKK1
alias: MAPK/ERK kinase 1
alias: MAPKK1
alias: ERK activator kinase 1
alias: MEK 1
alias: MAP kinase kinase 1
alias: mitogen-activated protein kinase kinase 1
alias: PRKMK1
alias: EC 2.7.12.2
title: MAP2K1
hgnc name: MAP2K1
URN: urn:edrn:bmdb:biomarker:928
description: MAP2K1, or mitogen-activated protein kinase kinase 1, is a dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MAP2K1 is located upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. MAP2K1 is thought to be involved in binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors, as well as cellular processes such as proliferation, differentiation, transcription regulation and development.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.ncbi.nlm.nih.gov/gene/5604
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q02750

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/364
type: Biomarker
alias: DEFB1
alias: P60022
alias: DEFB-1
alias: hBD-1
alias: HBD-1
alias: beta-defensin-1
alias: Defensin, beta 1
alias: HBD1
alias: DEFB101
alias: defensin, beta 1
alias: BD1
alias: beta-defensin 1
alias: BD-1
title: DEFB1
hgnc name: DEFB1
URN: urn:edrn:bmdb:biomarker:364
description: DEFB1 is a member of the defensin family of microbicidal and cytotoxic peptides made by neutrophils. DEFB1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. DEFB1 is thought to be involved in the pathogenesis of cystic fibrosis.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:2766
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/1672
references resource: P60022

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/118
type: Biomarker
alias: proPSA
alias: [-2]proPSA
alias: free prostate-specific antigen (PSA) isoform
title: proPSA
URN: urn:edrn:bmdb:biomarker:118
description: ProPSA (-2), or [-2]proPSA, is a PSA isoform which has a leader peptide (-2) amino acids at its N terminal region and does not interact with ACT or alpha-2-macroglobulin or spermidine and therefore is detected as a separate isoform. ProPSA is produced primarily in the peripheral zone of the prostate gland and therefore is very useful in distinguishing between prostate cancer patients with PSA range of 2-10, from those who have BPH. Percent proPSA is the ratio of proPSA to free PSA. In July 2012 the FDA approved an assay measuring levels of [-2]proPSA for monitoring and diagnostic purposes.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Chan Johns Hopkins Medical Institutions
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/87
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/97
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/98
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/250
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/251
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/354
references resource: PSA
references resource: ucm309081.htm
references resource: proPSA
references resource: P090026b.pdf
references resource: K112603.pdf
references resource: P090026c.pdf

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/895
type: Biomarker
alias: APAF1
alias: apoptotic protease activating factor
alias: CED4
alias: KIAA0413
alias: apoptotic peptidase activating factor 1
alias: apoptotic protease-activating factor 1
alias: APAF-1
alias: apoptotic peptidase activating factor
title: APAF1
hgnc name: APAF1
URN: urn:edrn:bmdb:biomarker:895
description: From NCBI Gene: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/317
references resource: O14727

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/893
type: Biomarker
alias: ANO1
alias: Discovered on gastrointestinal stromal tumors protein 1
alias: oral cancer overexpressed 2
alias: transmembrane protein 16A
alias: TMEM16A
alias: Tumor-amplified and overexpressed sequence 2
alias: DOG1
alias: discovered on gastrointestinal stromal tumors protein 1
alias: Transmembrane protein 16A
alias: Oral cancer overexpressed protein 2
alias: transmembrane protein 16A (eight membrane-spanning domains)
alias: FLJ10261
alias: TAOS2
alias: ORAOV2
alias: tumor-amplified and overexpressed sequence 2
alias: anoctamin 1, calcium activated chloride channel
alias: anoctamin-1
title: ANO1
hgnc name: ANO1
URN: urn:edrn:bmdb:biomarker:893
description: ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/216
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/55107
references resource: Q5XXA6

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/548
type: Biomarker
alias: Spira 80-marker panel for lung cancer
alias: 80-gene panel
alias: 80 Gene Panel for Lung Cancer
title: 80 Gene Panel for Lung Cancer
URN: urn:edrn:bmdb:biomarker:548
description: This 80-gene biomarker panel is used to distinguish smokers with lung cancer from smokers without lung cancer. The biomarker panel had approximately 90% sensitivity for stage 1 cancer across all subjects. Adding cytopathology data gives 95% sensitivity and 95% negative predictive value. (7 of the 80 biomarker probesets had no annotated gene symbol associated with them.) List of genes in the panel: DMD, NELL2, FGF14, TMEM47, ANXA3, PLA2G4A, DNAJC12, SLC39A8, DEFB1, PPBP, C6, FCGR3A, IL8, SERPINA1, CXCL2, RGS1, DUSP6, TOB1, FOS, SOX9, CD55, CD55, SLC4A4, CD164, ATP6AP2, ARL6IP5, CCT2, UBXD2, RAB1A, TRAM1, TMED2, YWHAE, C1orf80, TPD52, ACTR2, CPNE3, PTK9, UBE2J1, FXR1, SPN, PPP2CA, AD7C-NTP, STARD7, KIAA0738, RPL35A, GTF2H3, ZNF611, LOC152719, PRR11, ZC3H7B, ZNF354A, UBE2D2, ZNF160, FBXW12, ALMS1, ATP8B1, BACH2, TSR1, HDGF2, FLJ14346, LOC653471, DCLRE1C, DUOX1, LOC153561, DKFZP434A0131, GLT28D1, SENP6, FTO, LMO4, CCDC81, COX5B, FTL, NUCKS1
QA state: Curated
security: Public
type: Gene
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
access granted to: Spira Boston University
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/148

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/931
type: Biomarker
alias: MYO5A
alias: myoxin
alias: dilute myosin heavy chain, non-muscle
alias: Myosin heavy chain 12
alias: unconventional myosin-Va
alias: Dilute myosin heavy chain, non-muscle
alias: Myosin-12
alias: MYO5
alias: GS1
alias: myosin VA (heavy chain 12, myoxin)
alias: myosin V
alias: myosin-12
alias: myosin, heavy polypeptide kinase
alias: MYR12
alias: myosin VA (heavy polypeptide 12, myoxin)
alias: MYH12
alias: myosin-Va
alias: Myoxin
title: MYO5A
hgnc name: MYO5A
URN: urn:edrn:bmdb:biomarker:931
description: The MYO5A gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. The MYO5A protein functions as a processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. MYO5A is also involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. Different isoforms, encoded by alternatively spliced transcript variants, have been reported.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/4644
references resource: Q9Y4I1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/395
type: Biomarker
alias: ST14
alias: Q9Y5Y6
alias: suppression of tumorigenicity 14 (colon carcinoma)
alias: MT-SP1
alias: SNC19
alias: HAI
alias: TMPRSS14
alias: Membrane-type serine protease 1
alias: Serine protease 14
alias: Serine protease TADG-15
alias: Tumor-associated differentially-expressed gene 15 protein
alias: PRSS14
alias: TADG15
alias: EC 3.4.21.109
alias: MTSP1
alias: OTTHUMP00000230931
alias: OTTHUMP00000230932
alias: prostamin
alias: suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
alias: suppressor of tumorigenicity 14 protein
alias: tumor associated differentially expressed gene 15 protein
alias: Matriptase
alias: Prostamin
alias: EC 3.4.21
title: ST14
hgnc name: ST14
URN: urn:edrn:bmdb:biomarker:395
description: From NCBI Gene: The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6768
references resource: Q9Y5Y6

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/377
type: Biomarker
alias: GPR105
alias: Q15391
alias: P2RY14
alias: G protein coupled receptor for UDP-glucose
alias: KIAA0001
alias: P2Y14 receptor
alias: purinergic receptor P2Y, G-protein coupled, 14
alias: P2Y(14) receptor
alias: UDP-glucose receptor
alias: P2Y purinoceptor 14
alias: G protein-coupled receptor 105
alias: P2Y14
alias: G-protein coupled receptor 105
title: P2RY14
hgnc name: P2RY14
URN: urn:edrn:bmdb:biomarker:377
description: From NCBI Gene: The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/9934
references resource: Q15391

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/56
type: Biomarker
alias: hK2
alias: KLK2
alias: kallikrein-related peptidase 2
alias: KLK2A2
alias: MGC12201
alias: glandular kallikrein 2
alias: kallikrein 2, prostatic
alias: Tissue kallikrein-2
alias: hGK-1
alias: Glandular kallikrein-1
alias: Kallikrein-2
title: KLK2
hgnc name: KLK2
URN: urn:edrn:bmdb:biomarker:56
description: The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. The glandular kallikrein gene family comprises 25 to 30 highly homologous genes that encode specific proteases involved in the processing of biologically active peptides (they cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin). Several human kallikrein genes have been isolated.
QA state: Accepted
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/69
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/70
references resource: P20151
references resource: !/hgnc id/HGNC:6363
references resource: ENSG00000167751
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/77
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/56/24
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/56/59

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/949
type: Biomarker
alias: SLA
alias: src-like-adapter
alias: SLAP-1
alias: SLAP
alias: Src-like-adapter
alias: Src-like-adaptor
alias: SLAP1
alias: src-like-adapter protein 1
alias: hSLAP
alias: SLA1
alias: Src-like-adapter protein 1
title: SLA
hgnc name: SLA
URN: urn:edrn:bmdb:biomarker:949
description: SLA, or Src-like-adaptor, is an adaptor protein involved in negative regulation of T-cell receptor (TCR) signaling and regulation of receptor tyrosine kinase signaling by direct association. SLA is also involved in the negative regulation of positive selection and mitosis of T-cells.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6503
references resource: Q13239

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/367
type: Biomarker
alias: EPB41L3
alias: Q9Y2J2
alias: 4.1B
alias: band 4.1-like protein 3
alias: DAL1
alias: KIAA0987
alias: differentially expressed in adenocarcinoma of the lung protein 1
alias: DAL-1
alias: erythrocyte membrane protein band 4.1-like 3
alias: Differentially expressed in adenocarcinoma of the lung protein 1
title: EPB41L3
hgnc name: EPB41L3
URN: urn:edrn:bmdb:biomarker:367
description: EPB41L3 protein is a critical growth regulator in the pathogenesis of meningiomas. There are three isoforms of this protein, produced by alternative splicing.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/213
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/23136
references resource: Q9Y2J2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/908
type: Biomarker
alias: DNAJC7
alias: dnaJ homolog subfamily C member 7
alias: DANJC7
alias: tetratricopeptide repeat domain 2
alias: Tetratricopeptide repeat protein 2
alias: DJC7
alias: TTC2
alias: tetratricopeptide repeat protein 2
alias: TPR repeat protein 2
alias: DnaJ (Hsp40) homolog, subfamily C, member 7
alias: DJ11
alias: TPR2
title: DNAJC7
hgnc name: DNAJC7
URN: urn:edrn:bmdb:biomarker:908
description: DNAJC7 is a member of the DNAJ heat shock protein 40 family. This family is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. DNAJC7 functions as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. There are pseudogenes of this gene on chromosomes 1 and 6. Multiple transcript variants of DNAJC7 exist from alternate splicing.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/7266
references resource: Q99615

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/88
type: Biomarker
alias: sVCAM-1
alias: serum vascular cell adhesion protein 1
alias: VCAM1
alias: vascular cell adhesion molecule 1
alias: CD106
alias: MGC99561
alias: INCAM-100
alias: DKFZp779G2333
alias: L1CAM
alias: CD_antigen=CD106
alias: sV-CAM
title: VCAM1
hgnc name: VCAM1
URN: urn:edrn:bmdb:biomarker:88
description: VCAM1, a single-pass type I membrane protein belonging to the Ig superfamily, is a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. It mediates leukocyte-endothelial cell adhesion and signal transduction. VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. VCAM1 may play a role in the development of artherosclerosis and rheumatoid arthritis. VCAM1 is expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Instititute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: !/hgnc id/HGNC:12663
references resource: P19320
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 001069.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/894
type: Biomarker
alias: AP3B2
alias: NAPTB
alias: Neuronal adaptin-like protein, beta-subunit
alias: Neuron-specific vesicle coat protein beta-NAP
alias: adapter-related protein complex 3 subunit beta-2
alias: beta-3B-adaptin
alias: adaptor protein complex AP-3 subunit beta-2
alias: adaptor-related protein complex 3, beta 2 subunit
alias: Clathrin assembly protein complex 3 beta-2 large chain
alias: Adaptor protein complex AP-3 subunit beta-2
alias: neuron-specific vesicle coat protein beta-NAP
alias: clathrin assembly protein complex 3 beta-2 large chain
alias: AP-3 complex subunit beta-2
alias: Adapter-related protein complex 3 subunit beta-2
alias: Beta-3B-adaptin
title: AP3B2
hgnc name: AP3B2
URN: urn:edrn:bmdb:biomarker:894
description: From NCBI Gene: Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017]
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8120
references resource: B7ZKR7

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/369
type: Biomarker
alias: EVA1
alias: O60487
alias: MPZL2
alias: epithelial V-like antigen 1
alias: Epithelial V-like antigen 1
alias: myelin protein zero-like protein 2
alias: myelin protein zero-like 2
alias: EVA
title: MPZL2
hgnc name: MPZL2
URN: urn:edrn:bmdb:biomarker:369
description: From NCBI Gene: Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/199
references resource: !/hgnc id/HGNC:3496
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/10205
references resource: O60487

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/357
type: Biomarker
alias: ACTR3
alias: P61158
alias: ARP3 actin-related protein 3 homolog (yeast)
alias: actin-like protein 3
alias: ARP3
alias: ARP3 (actin-related protein 3, yeast) homolog
alias: Actin-like protein 3
alias: actin-related protein 3
title: ACTR3
hgnc name: ACTR3
URN: urn:edrn:bmdb:biomarker:357
description: From NCBI Gene: The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:170
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/10096
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/372
type: Biomarker
alias: FLJ23594
alias: Q68D86
alias: CCDC102B
alias: HsT1731
alias: chromosome 18 open reading frame 14
alias: coiled-coil domain-containing protein 102B
alias: coiled-coil domain containing 102B
alias: C18orf14
alias: aminoacylase 1-like
alias: AN
alias: ACY1L
title: CCDC102B
hgnc name: CCDC102B
URN: urn:edrn:bmdb:biomarker:372
description: CCDC102B, or coiled-coil domain-containing protein 102B, has two isoforms produced by alternative splicing.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/
references resource: Q68D86

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/772
type: Biomarker
alias: PGC
alias: preprogastricsin
alias: gastricsin
alias: pepsinogen group II
alias: Pepsinogen C
alias: pepsin C
alias: progastricsin (pepsinogen C)
alias: pepsinogen C
alias: PEPC
alias: PGII
alias: EC 3.4.23.3
alias: Progastricsin
alias: EC 3.4.23
title: PGC
hgnc name: PGC
URN: urn:edrn:bmdb:biomarker:772
description: From NCBI Gene: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/5225
references resource: P20142
references resource: http://www.omim.org/entry/169740

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/909
type: Biomarker
alias: DUSP9
alias: dual specificity protein phosphatase 9
alias: mitogen-activated protein kinase phosphatase 4
alias: dual specificity phosphatase 9
alias: Mitogen-activated protein kinase phosphatase 4
alias: serine/threonine specific protein phosphatase
alias: map kinase phosphatase 4
alias: MKP-4
alias: MAP kinase phosphatase 4
alias: MKP4
alias: EC 3.1.3.16,EC 3.1.3.48
title: DUSP9
hgnc name: DUSP9
URN: urn:edrn:bmdb:biomarker:909
description: DUSP9 is a member of the dual specificity protein phosphatase subfamily. DUSP9 is specific for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/1852
references resource: Q99956

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/962
type: Biomarker
alias: XBP1
alias: XBP-1
alias: XBP2
alias: tax-responsive element-binding protein 5
alias: Tax-responsive element-binding protein 5
alias: TREB5
alias: X-box binding protein 1
alias: X-box-binding protein 1
title: XBP1
hgnc name: XBP1
URN: urn:edrn:bmdb:biomarker:962
description: XBP1 is a transcription factor involved in hepatocyte growth, differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 also plays a role in activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE) during endoplasmic reticulum stress. There is an XBP1 pseudogene on chromosome 5.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/234
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/7494
references resource: P17861

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/934
type: Biomarker
alias: PCCA
alias: propionyl CoA carboxylase, alpha polypeptide
alias: PCCase alpha subunit
alias: propionyl Coenzyme A carboxylase, alpha polypeptide
alias: PCCase subunit alpha
alias: propionyl-CoA carboxylase alpha chain, mitochondrial
alias: propanoyl-CoA:carbon dioxide ligase alpha subunit
alias: Propanoyl-CoA:carbon dioxide ligase subunit alpha
alias: pccA complementation group
alias: EC 6.4.1.3
title: PCCA
hgnc name: PCCA
URN: urn:edrn:bmdb:biomarker:934
description: PCCA, or propionyl CoA carboxylase, alpha polypeptide, is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. The beta subunit is PCCB. The enzyme deficiency propionic acidemia results from mutations in either PCCA or PCCB. Several isoforms for this gene have been identified, coded by multiple transcript variants.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/5095
references resource: P05165

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/635
type: Biomarker
alias: DPP4
alias: CD26
alias: Dipeptidyl peptidase IV
alias: dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
alias: TP103
alias: ADABP
alias: dipeptidyl peptidase 4
alias: T-cell activation antigen CD26
alias: CD26 antigen
alias: adenosine deaminase complexing protein 2
alias: dipeptidyl-peptidase 4
alias: DPP IV
alias: ADCP-2
alias: dipeptidylpeptidase 4
alias: Adenosine deaminase complexing protein 2
alias: ADCP2
alias: dipeptidyl peptidase IV
alias: DPPIV
alias: EC 3.4.14.5
title: DPP4
hgnc name: DPP4
URN: urn:edrn:bmdb:biomarker:635
description: From NCBI Gene: The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/1803
references resource: P27487
references resource: http://www.omim.org/entry/102720
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/892
type: Biomarker
alias: ADH5
alias: GSH-FDH
alias: alcohol dehydrogenase class-III
alias: ADHX
alias: alcohol dehydrogenase (class III), chi polypeptide
alias: GSNOR
alias: Glutathione-dependent formaldehyde dehydrogenase
alias: FALDH
alias: FDH
alias: Alcohol dehydrogenase 5
alias: ADH-3
alias: alcohol dehydrogenase class chi chain
alias: alcohol dehydrogenase class-3
alias: Alcohol dehydrogenase class chi chain
alias: glutathione-dependent formaldehyde dehydrogenase
alias: Alcohol dehydrogenase class-III
alias: formaldehyde dehydrogenase
alias: S-(hydroxymethyl)glutathione dehydrogenase
alias: alcohol dehydrogenase 5 (class III), chi polypeptide
alias: EC 1.1.1.1,EC 1.1.1.-,EC 1.1.1.284
title: ADH5
hgnc name: ADH5
URN: urn:edrn:bmdb:biomarker:892
description: From NCBI Gene: This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Anderson Arizona State University
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/128
references resource: Q6IRT1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/370
type: Biomarker
alias: FJX1
alias: Q86VR8
alias: putative secreted ligand homologous to fjx1
alias: Four-jointed protein homolog
alias: FLJ25593
alias: four-jointed box protein 1
alias: four jointed box 1 (Drosophila)
alias: four-jointed protein homolog
alias: FLJ22416
title: FJX1
hgnc name: FJX1
URN: urn:edrn:bmdb:biomarker:370
description: FJX1 is the human ortholog of mouse and Drosophila four-jointed gene product. The Drosophila protein is important for growth and differentiation of legs and wings, and for proper development of the eyes. It is predicted, based on similarity, that human FJX1 may act as an inhibitor of dendrite extension and branching.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/24147
references resource: http://www.ncbi.nlm.nih.gov/pubmed/

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1008
type: Biomarker
alias: MPG
alias: N-methylpurine DNA glycosylase
alias: 3-Alkyladenine DNA Glycosylase
alias: 3-Methyladenine DNA Glycosidase
alias: AAG
alias: ADPG
alias: MDG
alias: Alkyladenine DNA Glycosylase
alias: 3' End Of The Mid1 Gene, Localized 68 Kb Upstream The Humanzeta Globin Gene On 16p
alias: APNG
alias: CRA36.1
alias: Mid1
alias: PIG11
alias: anpg
alias: PIG16
alias: CRA36.1 (3-Methyl-Adenine DNA Glycosylase)
alias: DNA-3-Methyladenine Glycosylase
alias: N-Methylpurine-DNA Glycosylase, MPG
alias: Proliferation-Inducing Protein 11
alias: Proliferation-Inducing Protein 16
alias: ANPG
alias: EC 3.2.2.21
alias: MID1
title: MPG
hgnc name: MPG
URN: urn:edrn:bmdb:biomarker:1008
description: MPG is a DNA repair enzyme that repairs hypoxanthine, which is formed by spontaneous or oxidative deamination of adenine. MPG also repairs secondary oxidative lesions such as 1,N6-ethenoadenine alkylated bases, and 3-methyladenine and 7-methylguanine.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/209
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/210
references resource: !/hgnc id/HGNC:7211
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/4350
references resource: P29372

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/959
type: Biomarker
alias: TSPO
alias: PBRS
alias: PBR
alias: PKBS
alias: Peripheral-type benzodiazepine receptor
alias: benzodiazapine receptor (peripheral)
alias: translocator protein
alias: PTBR
alias: BPBS
alias: mitochondrial benzodiazepine receptor
alias: translocator protein (18kDa)
alias: BZRP
alias: DBI
alias: peripheral-type benzodiazepine receptor
alias: Mitochondrial benzodiazepine receptor
alias: IBP
alias: MBR
alias: pk18
alias: mDRC
alias: PBS
alias: benzodiazepine peripheral binding site
title: TSPO
hgnc name: TSPO
URN: urn:edrn:bmdb:biomarker:959
description: TSPO is a conserved protein found at the outer mitochondrial membrane. TSPO interacts with some benzodiazepines and isoquinoline carboxamides and has different affinities than its endogenous counterpart. TSPO is also involved in the transport of porphyrins and heme.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/231
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/232
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/706
references resource: P30536

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/382
type: Biomarker
alias: KIAA0143
alias: Q14156
alias: Protein EFR3-like
alias: protein EFR3 homolog A
alias: EFR3 homolog A (S. cerevisiae)
alias: EFR3A
title: EFR3A
hgnc name: EFR3A
URN: urn:edrn:bmdb:biomarker:382
description: From NCBI Gene: The protein encoded by this gene is part of a complex that plays a role in maintaining an active pool of phosphatidylinositol 4-kinase (PI4K) at the plasma membrane. This protein is thought to be a peripheral membrane protein that associates with the plasma membrane through palmitoylation. Studies indicate that this gene product plays a role in controlling G protein-coupled receptor (GPCR) activity by affecting receptor phosphorylation. Whole exome sequencing studies have implicated mutations in this gene with autism spectrum disorders. [provided by RefSeq, Apr 2016]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:28970
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/23167
references resource: Q14156

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/853
type: Biomarker
alias: TGM4
alias: transglutaminase 4 (prostate)
alias: transglutaminase P
alias: TGase-4
alias: TGase P
alias: Prostate-specific transglutaminase
alias: protein-glutamine gamma-glutamyltransferase 4
alias: TGP
alias: TG(P)
alias: Transglutaminase P
alias: transglutaminase-4
alias: prostate-specific transglutaminase
alias: Prostate transglutaminase
alias: fibrinoligase
alias: hTGP
alias: Fibrinoligase
alias: prostate transglutaminase
alias: Transglutaminase-4
alias: EC 2.3.2.13
title: TGM4
hgnc name: TGM4
URN: urn:edrn:bmdb:biomarker:853
description: From NCBI Gene: Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in peptide cross-linking. Predicted to act upstream of or within mating plug formation. Located in Golgi apparatus and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Nov 2021]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/7047
references resource: P49221
references resource: http://www.omim.org/entry/600585
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/374
type: Biomarker
alias: FNDC3A
alias: Q9Y2H6
alias: FNDC3
alias: bA203I16.5
alias: KIAA0970
alias: human gene expressed in odontoblasts
alias: bA203I16.1
alias: Human gene expressed in odontoblasts
alias: fibronectin type III domain containing 3A
alias: fibronectin type-III domain-containing protein 3A
alias: fibronectin type III domain containing 3
alias: HUGO
title: FNDC3A
hgnc name: FNDC3A
URN: urn:edrn:bmdb:biomarker:374
description: Fndc3a is a member of a three-gene family in mice. Mouse Fndc3a is composed of a proline-rich amino-terminus, nine fibronectin type-III domains, and a hydrophobic carboxy-terminus. By similarity, human FNDC3A is thought to mediate spermatid-Sertoli adhesion during spermatogenesis.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:20296
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q9Y2H6
references resource: http://www.ncbi.nlm.nih.gov/gene/22862

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/243
type: Biomarker
alias: interleukin 6 receptor
alias: IL6R
alias: CD126
alias: Membrane glycoprotein 80
alias: IL-6R-alpha
alias: IL-6RA
alias: CD126 antigen
alias: gp80
alias: IL-6 receptor subunit alpha
alias: IL-6R 1
alias: IL-6R subunit alpha
alias: IL-6R-1
alias: IL6RA
alias: MGC104991
alias: OTTHUMP00000217870
alias: interleukin 6 receptor alpha subunit
alias: interleukin-6 receptor subunit alpha
title: IL6R
hgnc name: IL6R
URN: urn:edrn:bmdb:biomarker:243
description: The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal transducer) subunit. The IL6R subunit binds to IL6 (interleukin 6) with low affinity, but does not transduce a signal. The IL6ST subunit is needed for signal activation. Impaired regulation of IL6 and IL6R have been linked to many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. Isoforms encoded by alternatively spliced transcripts have been reported. Activation of the IL6/IL6R/IL6ST complex may lead to the regulation of the immune response, acute-phase reactions, and hematopoiesis.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:6019
references resource: P08887
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000160712
references resource: AAH89410.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1012
type: Biomarker
alias: HIST1H2BI
alias: Histone H2B.A
alias: Histone H2B.K
alias: Histone H2B.1 A
alias: Histone 1, H2bi
alias: Histone Cluster 1, H2bi
alias: Histone H2B Type 1-C/E/F/G/I
alias: H2B Histone Family, Member K
alias: Histone Cluster 1 H2B Family Member I
alias: H2BFK
alias: H2B/K
alias: H2B Clustered Histone 10
alias: H2BC10
alias: Histone H2B.G
alias: Histone H2B.H
alias: Histone H2B.L
alias: HIST1H2BC
alias: HIST1H2BE
alias: HIST1H2BF
alias: HIST1H2BG
alias: H2BC4
alias: H2BC6
alias: H2BC7
alias: H2BC8
alias: H2BFL
alias: H2BFH
alias: H2BFG
alias: H2BFA
alias: H2B/A
alias: H2B/G
alias: H2B/H
alias: H2B/L
title: H2BC10
hgnc name: H2BC10
URN: urn:edrn:bmdb:biomarker:1012
description: This gene was formerly known as HIST1H2BI. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. The protein has antibacterial and antifungal antimicrobial activity. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/8346
references resource: P62807
references resource: http://omim.org/entry/602807
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/539
type: Biomarker
alias: GATA4
alias: GATA Binding Protein 4
alias: GATA-Binding Factor 4
alias: GATA-Binding Protein 4
alias: ASD2
alias: VSD1
alias: Transcription Factor GATA-4
title: GATA4
hgnc name: GATA4
URN: urn:edrn:bmdb:biomarker:539
description: From NCBI Entrez Gene: This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/128
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/2626
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P43694

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/27
type: Biomarker
alias: Osteopontin
alias: Bone sialoprotein 1
alias: Secreted phosphoprotein 1
alias: SPP-1
alias: Urinary stone protein
alias: Nephropontin
alias: Uropontin
alias: BNSP
alias: OPN
alias: BSPI
alias: ETA-1
alias: early T-lymphocyte activation 1
alias: SPP1
alias: Osteopontin (OPN)
title: Osteopontin
hgnc name: SPP1
URN: urn:edrn:bmdb:biomarker:27
description: From NCBI Gene: The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
QA state: Curated
security: Public
type: Proteomic
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: Marks Duke University Medical Center
access granted to: Mor Yale University
access granted to: National Cancer Institute
access granted to: Pass New York University School of Medicine
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/18
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/21
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/43
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/48
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/254
references resource: P10451
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: !/hgnc id/HGNC:11255
references resource: NP 001238759.1
references resource: https://www.ncbi.nlm.nih.gov/gene/6696

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/70
type: Biomarker
alias: CTAP-III
alias: PPBP
alias: THBGB1
alias: SCYB7
alias: TGB
alias: NAP-2-L1
alias: LA-PF4
alias: MDGF
alias: LDGF
alias: Beta-TG
alias: CTAP3
alias: CXCL7
alias: PBP
alias: b-TG1
alias: TGB1
alias: CTAPIII
alias: NAP-2
alias: pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
alias: platelet basic protein
alias: beta-thromboglobulin
alias: connective tissue-activating peptide III
alias: neutrophil-activating peptide-2
alias: TC1
alias: TC2
alias: B-TG1
alias: THBGB
alias: thrombocidin 1
alias: thrombocidin 2
alias: CXC chemokine ligand 7
alias: thromboglobulin, beta-1
alias: small inducible cytokine B7
alias: leukocyte-derived growth factor
alias: low-affinity platelet factor IV
alias: neutrophil-activating peptide 2
alias: macrophage-derived growth factor
alias: small inducible cytokine subfamily B, member 7
alias: pro-platelet basic protein
title: PPBP
hgnc name: PPBP
URN: urn:edrn:bmdb:biomarker:70
description: CTAP-III (officially named PPBP) is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and sythesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Bast MD Anderson
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/173
references resource: !/hgnc id/HGNC:9240
references resource: P02775
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 002695.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/948
type: Biomarker
alias: RNF113A
alias: Zinc finger protein 183
alias: RING finger protein 113A
alias: Cwc24
alias: zinc finger protein 183 (RING finger, C3HC4 type)
alias: RNF113
alias: ZNF183
alias: ring finger protein 113A
title: RNF113A
hgnc name: RNF113A
URN: urn:edrn:bmdb:biomarker:948
description: RNF113A is a member of the RNF family, or RING-type zinc finger proteins. The RNF proteins are a subset of the larger family of zinc finger proteins. Members of the RNF family have an enzyme activity known as E3 ubiquitin-protein ligase which targets other proteins to be degraded within cells. RNF113A contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is present in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is implicated in mediating protein-protein interactions.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/7737
references resource: O15541

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/54
type: Biomarker
alias: TSP
alias: TSP-1
alias: THBS1
alias: Thrombospondin-1
alias: THBS
alias: THBS-1
alias: thrombospondin-1p180
alias: TSP1
alias: Thrombospondin (THBS)
title: THBS1
hgnc name: THBS1
URN: urn:edrn:bmdb:biomarker:54
description: TSP is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. TSP can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. It has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis.
QA state: Accepted
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Haab Van Andel Research Institute
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/66
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/250
references resource: !/hgnc id/HGNC:11785
references resource: P07996
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000137801
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/75
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1225
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1592
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/54/22
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/54/23
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/54/1041
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/54/1695
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/54/2087

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/151
type: Biomarker
alias: BCAM
alias: Basal cell adhesion molecule
alias: basal cell adhesion molecule (Lutheran blood group)
alias: LU
alias: Lutheran blood group (Auberger b antigen included)
alias: basal cell adhesion molecule (Lu and Au blood groups)
alias: CD239
alias: AU
alias: MSK19
alias: Auberger B antigen
alias: B-CAM cell surface glycoprotein
alias: F8/G253 antigen
alias: Lutheran antigen
alias: Lutheran blood group glycoprotein
alias: CD_antigen=CD239
title: BCAM
hgnc name: BCAM
URN: urn:edrn:bmdb:biomarker:151
description: From NCBI Gene: This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Diamandis Mount Sinai Hospital
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Skates Massachusetts General Hospital
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/191
references resource: !/hgnc id/HGNC:6722
references resource: https://www.ncbi.nlm.nih.gov/gene/4059
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/65
type: Biomarker
alias: MMP7
alias: MPSL1
alias: matrix metalloproteinase 7 (matrilysin, uterine)
alias: PUMP-1
alias: Matrilysin
alias: Pump-1 protease
alias: Uterine metalloproteinase
alias: MMP-7
title: MMP7
hgnc name: MMP7
URN: urn:edrn:bmdb:biomarker:65
description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1271
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: McIntosh Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/82
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:7174
references resource: P09237
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 002414.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/244
type: Biomarker
alias: Lutropin
alias: LHB
alias: luteinizing hormone beta polypeptide
alias: LSH-B
alias: CGB4
alias: hLHB
alias: LH-B
alias: Lutropin beta chain
alias: LSH-beta
alias: interstitial cell stimulating hormone, beta chain
alias: luteinizing hormone beta subunit
alias: lutropin subunit beta
alias: Luteinizing hormone subunit beta
title: LHB
hgnc name: LHB
URN: urn:edrn:bmdb:biomarker:244
description: The pituitary glycoprotein hormone family includes follicle stimulating hormone (FSH), luteinizing hormone (LH), chorionic gonadotropin (CG), and thyroid-stimulating hormone (TSH). All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. LHB, the beta subunit of luteinizing hormone, confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: !/hgnc id/HGNC:6584
references resource: http://www.ncbi.nlm.nih.gov/gene/3972
references resource: P01229

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/25
type: Biomarker
alias: CA19-9
alias: carbohydrate antigen 19-9
alias: cancer antigen 19-9
alias: CA199
alias: CA 19.9
title: CA19-9
URN: urn:edrn:bmdb:biomarker:25
description: CA19-9 is a monoclonal antibody that was first discovered in the serum of patients with colon cancer. Since that time CA19-9 has been used as a tumor marker for a variety of cancers.
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1468
access granted to: Breast and Gynecologic
access granted to: Cramer Brigham and Women's Hospital
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/13
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/14
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/246
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/252
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/46
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/918
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1074
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1118
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/34
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/35
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/917
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/929
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/961
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/1016
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/1647
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/1656
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/1659
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/1729
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/1735
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/1738
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/25/1772

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/960
type: Biomarker
alias: TSSK3
alias: testis-specific serine/threonine-protein kinase 3
alias: Testis-specific kinase 3
alias: Serine/threonine-protein kinase 22C
alias: testis-specific serine/threonine kinase 22C
alias: spermiogenesis associated 3
alias: serine/threonine kinase 22C (spermiogenesis associated)
alias: TSSK-3
alias: testis-specific serine kinase 3
alias: serine/threonine-protein kinase 22C
alias: STK22C
alias: TSK-3
alias: SPOGA3
alias: TSK3
alias: testis-specific kinase 3
alias: STK22D
alias: EC 2.7.11.1
title: TSSK3
hgnc name: TSSK3
URN: urn:edrn:bmdb:biomarker:960
description: TSSK3 is a testis-specific kinase that is thought to be involved in either germ cell differentiation or mature sperm function.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/81629
references resource: Q96PN8

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1140
type: Biomarker
alias: CA9
alias: Carbonic Anhydrase 9
alias: Carbonic Anhydrase IX
alias: Renal Cell Carcinoma-Associated Antigen G250
alias: RCC-Associated Protein G250
alias: RCC-Associated Antigen G250
alias: Carbonate Dehydratase IX
alias: Carbonic Dehydratase
alias: Membrane Antigen MN
alias: P54/58N
alias: CA-IX
alias: CAIX
alias: PMW1
alias: MN
alias: EC 4.2.1.1
alias: G250
title: CA9
URN: urn:edrn:bmdb:biomarker:1140
description: From NCBI Gene: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]
QA state: Curated
security: Public
type: Genetic
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
references resource: !/hgnc id/HGNC:1383
references resource: https://www.ncbi.nlm.nih.gov/gene/768
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q16790

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/389
type: Biomarker
alias: PSMAL
alias: Q9HBA9
alias: prostate-specific membrane antigen-like protein
alias: FOLH2
alias: cell growth-inhibiting gene 26 protein
alias: NAALADase
alias: folate hydrolase 1B
alias: folate hydrolase pseudogene
alias: putative N-acetylated-alpha-linked acidic dipeptidase
alias: N-acetylated-alpha-linked-acidic dipeptidase
alias: Putative folate hydrolase 1B
alias: Prostate-specific membrane antigen-like protein
alias: GCP3
alias: Cell growth-inhibiting gene 26 protein
alias: folate hydrolase 2
alias: PSMA-LIKE
alias: FOLHP
alias: PSM
alias: putative folate hydrolase 1B
alias: GCPIII
alias: glutamate carboxypeptidase III
alias: EC 3.4.-.-
alias: FOLH1B
title: FOLH1B
hgnc name: FOLH1B
URN: urn:edrn:bmdb:biomarker:389
description: FOLH1B, or PSMAL, is a cytoplasmic protein. It has been found in the kidney and liver, and has not been detected in the prostate. GO annotations related to this gene include metallopeptidase activity and dipeptidase activity.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: !/hgnc id/HGNC:13636
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/219595
references resource: Q9HBA9

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/226
type: Biomarker
alias: KRT19
alias: Cytokeratin 19
alias: keratin 19
alias: 40-kDa keratin intermediate filament
alias: CK19
alias: cytokeratin 19
alias: K1CS
alias: K19
alias: keratin, type I cytoskeletal 19
alias: keratin, type I, 40-kd
alias: MGC15366
alias: Cytokeratin-19
alias: CK-19
alias: Keratin-19
title: KRT19
hgnc name: KRT19
URN: urn:edrn:bmdb:biomarker:226
description: KRT19, a member of the keratin family which exists as a heterotetramer of two type I and two type II keratins, is involved in the organization of myofibers. Together with KRT8, KRT19 helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. KRT18 is expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. It is also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). It is expressed in epidermal basal cells and in nipple epidermis. It is also evident in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle, as well as in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/169
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/170
references resource: !/hgnc id/HGNC:6436
references resource: P08727
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 002267.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/236
type: Biomarker
alias: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
alias: MMP2
alias: TBE-1
alias: CLG4
alias: CLG4A
alias: 72 kDa type IV collagenase
alias: matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
alias: MMP-2
alias: MMP-II
alias: Gelatinase A
alias: Matrix metalloproteinase-2
alias: 72 kDa gelatinase
alias: collagenase type IV-A
alias: matrix metalloproteinase-II
alias: neutrophil gelatinase
alias: EC 3.4.24.24
title: MMP2
hgnc name: MMP2
URN: urn:edrn:bmdb:biomarker:236
description: MMP2 is a member of the matrix metalloproteinase (MMP) family and is involved in many functions, such as remodeling of the vasculature, angiogenesis, tissue repair and remodeling, tumor invasion, inflammation, atherosclerotic plaque rupture, reproduction and embryonic development, as well as in disease processes such as arthritis and metastasis. In addition to degrading extracellular matrix proteins, MMP2 can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction and appears to have a role in myocardial cell death pathways. MMPs are generally secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The MMP2 protein degrades gelatin type I and collagen types IV, V, VII, and X. MMP2 gene mutations have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. There are two known isoforms of this gene, encoded by two transcript variants.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: !/hgnc id/HGNC:7166
references resource: P08253
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 004521.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/359
type: Biomarker
alias: BLAME
alias: Q9P0V8
alias: SLAMF8
alias: B lymphocyte activator macrophage expressed
alias: B-lymphocyte activator macrophage expressed
alias: SLAM family member 8
alias: CD353 antigen
alias: BCM-like membrane protein
alias: CD353
alias: SBBI42
title: SLAMF8
hgnc name: SLAMF8
URN: urn:edrn:bmdb:biomarker:359
description: SLAMF8 is a membrane protein belonging to the CD2 family of cell surface proteins. This protein family is characterized by Ig domains. SLAMF8 is expressed in lymph node, spleen, thymus and bone marrow. SLAMF8 may play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. There are two isoforms of this protein, produced by alternative splicing.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/56833
references resource: Q9P0V8

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1007
type: Biomarker
alias: 8-oxoguanine DNA glycosylase
alias: OGG1
alias: 8-Hydroxyguanine DNA Glycosylase
alias: MUTM
alias: OGH1
alias: OGG1 Type 1d
alias: OGG1 Type 1e
alias: OGG1 Type 1g
alias: OGG1 Type 1h
alias: HMMH
alias: HOGG1
alias: AP Lyase
alias: DNA-Apurinic Or Apyrimidinic Site Lyase
alias: N-Glycosylase/DNA Lyase
alias: OGG1 Type 1f
alias: MMH
title: OGG1
hgnc name: OGG1
URN: urn:edrn:bmdb:biomarker:1007
description: 8-Oxoguanine DNA Glycosylase, or OGG1, is a DNA repair enzyme that removes both 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. OGG1 has a beta-lyase activity that nicks DNA 3' to the lesion. There are two major groups of splice variants for this gene, classified by alternative splicing of the C-terminal region of the gene, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/209
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/210
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/211
references resource: !/hgnc id/HGNC:8125
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: O15527
references resource: http://www.ncbi.nlm.nih.gov/gene/4968

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/227
type: Biomarker
alias: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
alias: ERBB2
alias: NGL
alias: HER2
alias: HER-2
alias: NEU
alias: CD340
alias: TKR1
alias: MLN 19
alias: HER-2/neu
alias: Receptor tyrosine-protein kinase erbB-2
alias: Metastatic lymph node gene 19 protein
alias: c-ErbB-2
alias: Tyrosine kinase-type cell surface receptor HER2
alias: p185erbB2
alias: CD_antigen=CD340
alias: MLN19
alias: Proto-oncogene Neu
alias: Proto-oncogene c-ErbB-2
alias: v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
title: ERBB2
hgnc name: ERBB2
URN: urn:edrn:bmdb:biomarker:227
description: From NCBI Gene: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/116
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/171
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:3430
references resource: P04626
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 004439.2
references resource: http://www.omim.org/entry/167000
references resource: http://www.ncbi.nlm.nih.gov/gene/2064

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/964
type: Biomarker
alias: YEATS4
alias: B230215M10Rik
alias: GAS41
alias: NuBI1
alias: nuBI1
alias: NuMA-binding protein 1
alias: NuBI-1
alias: glioma-amplified sequence 41
alias: glioma-amplified sequence-41
alias: YEATS domain containing 4
alias: NUBI-1
alias: YAF9
alias: Gas41
alias: 4930573H17Rik
alias: nuMA-binding protein 1
alias: Glioma-amplified sequence 41
alias: NuMA binding protein 1
alias: YEATS domain-containing protein 4
title: YEATS4
hgnc name: YEATS4
URN: urn:edrn:bmdb:biomarker:964
description: YEATS4 has high sequence similarity to human MLLT1, and yeast and human MLLT3 proteins, both transcription factors, and is therefore hypothesized to be a transcription factor itself. YEATS4 is thought to be required for RNA transcription. YEATS4 is also a component of the NuA4 histone acetyltransferase (HAT) complex.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8089
references resource: O95619

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/910
type: Biomarker
alias: EED
alias: hEED
alias: WAIT-1
alias: embryonic ectoderm development
alias: HEED
alias: WD protein associating with integrin cytoplasmic tails 1
alias: WAIT1
alias: polycomb protein EED
title: EED
hgnc name: EED
URN: urn:edrn:bmdb:biomarker:910
description: EED is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. EED is part of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. There are two known isoforms arising from two distinct transcript variants for this gene.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8726
references resource: O75530

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/903
type: Biomarker
alias: CD1A
alias: differentiation antigen CD1-alpha-3
alias: cluster of differentiation 1 A
alias: HTA1
alias: cortical thymocyte antigen CD1A
alias: CD1a antigen
alias: hTa1 thymocyte antigen
alias: epidermal dendritic cell marker CD1a
alias: CD1a molecule
alias: CD1A antigen, a polypeptide
alias: T-cell surface glycoprotein CD1a
alias: T6
alias: T-cell surface antigen T6/Leu-6
alias: FCB6
alias: CD1
alias: R4
title: CD1A
hgnc name: CD1A
URN: urn:edrn:bmdb:biomarker:903
description: CD1A is a transmembrane glycoprotein that is structurally related to the major histocompatibility complex (MHC) proteins and forms heterodimers with beta-2-microglobulin. CD1A functions as an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/909
references resource: P06126

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/230
type: Biomarker
alias: IGFBP1
alias: insulin-like growth factor binding protein 1
alias: IBP1
alias: AFBP
alias: alpha-pregnancy-associated endometrial globulin
alias: PP12
alias: IGF-BP25
alias: hIGFBP-1
alias: IBP-1
alias: IGF-binding protein 1
alias: IGFBP-1
alias: Placental protein 12
title: IGFBP1
hgnc name: IGFBP1
URN: urn:edrn:bmdb:biomarker:230
description: IGFBP1, a secreted protein, is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP1 promotes cell migration.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/174
references resource: !/hgnc id/HGNC:5469
references resource: P08833
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000587.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/932
type: Biomarker
alias: NDUFA10
alias: CI-42KD
alias: CI-42k
alias: NADH-ubiquinone oxidoreductase 42 kDa subunit
alias: Complex I-42kD
alias: CI-42kD
alias: complex I 42kDa subunit
alias: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
alias: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 (42kD)
alias: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
title: NDUFA10
hgnc name: NDUFA10
URN: urn:edrn:bmdb:biomarker:932
description: NDUFA10 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Mammalian complex I is the first enzyme complex in the electron transport chain of mitochondria. It is composed of 45 different subunits. This protein is a component of the hydrophobic protein fraction and has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/4705
references resource: O95299

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/858
type: Biomarker
alias: TNFSF10
alias: TNF-related apoptosis-inducing ligand
alias: Apo-2 ligand
alias: CD253
alias: tumor necrosis factor (ligand) family, member 10
alias: TL2
alias: tumor necrosis factor (ligand) superfamily, member 10
alias: TRAIL
alias: TNF-related apoptosis inducing ligand TRAIL
alias: tumor necrosis factor ligand superfamily member 10
alias: chemokine tumor necrosis factor ligand superfamily member 10
alias: Apo-2L
alias: Protein TRAIL
alias: tumor necrosis factor apoptosis-inducing ligand splice variant delta
alias: CD253 antigen
alias: APO2L
title: TNFSF10
hgnc name: TNFSF10
URN: urn:edrn:bmdb:biomarker:858
description: From NCBI Gene: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/8743
references resource: P50591
references resource: http://www.omim.org/entry/603598

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/940
type: Biomarker
alias: PTPN11
alias: Noonan syndrome 1
alias: Protein-tyrosine phosphatase 1D
alias: BPTP3
alias: protein tyrosine phosphatase, non-receptor type 11
alias: PTP2C
alias: tyrosine-protein phosphatase non-receptor type 11
alias: PTP-2C
alias: CFC
alias: SH-PTP2
alias: protein-tyrosine phosphatase 1D
alias: Shp2
alias: Protein-tyrosine phosphatase 2C
alias: SH-PTP3
alias: SHP2
alias: SHP-2
alias: protein-tyrosine phosphatase 2C
alias: PTP-1D
alias: SHPTP2
alias: NS1
alias: EC 3.1.3.48
title: PTPN11
hgnc name: PTPN11
URN: urn:edrn:bmdb:biomarker:940
description: PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTP family members are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. The activity of PTPs opposite that of kinases and phosphorylases and therefore PTPs play an integral role in many signal transduction pathways. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN11 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/5781
references resource: Q06124

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/376
type: Biomarker
alias: GPM6B
alias: Q13491
alias: M6B
alias: MGC17150
alias: neuronal membrane glycoprotein M6-b
alias: protolipid M6B
alias: glycoprotein M6B
alias: M6b
alias: MGC54284
title: GPM6B
hgnc name: GPM6B
URN: urn:edrn:bmdb:biomarker:376
description: GPM6B is a membrane glycoprotein belonging to the proteolipid protein family. It is thought to be involved in neural development. This protein family is expressed in the brain and may be involved in cellular housekeeping functions. GPM6B is involved in the regulation of osteoblast function and bone formation and matrix vesicle release by osteoblasts. GPM6B may be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/193
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/215
references resource: !/hgnc id/HGNC:4461
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/2824
references resource: Q13491

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/138
type: Biomarker
alias: PSAP
alias: prosaposin
alias: SAP1
alias: GLBA
alias: sphingolipid activator protein-1
alias: variant Gaucher disease and variant metachromatic leukodystrophy
alias: FLJ00245
alias: MGC110993
alias: Proactivator polypeptide
title: PSAP
hgnc name: PSAP
URN: urn:edrn:bmdb:biomarker:138
description: From NCBI Gene: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Diamandis Mount Sinai Hospital
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
references resource: !/hgnc id/HGNC:9498
references resource: https://www.ncbi.nlm.nih.gov/gene/5660
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/62
type: Biomarker
alias: KLK11
alias: hk11
alias: kallikrein-related peptidase 11
alias: kallikrein 11
alias: TLSP
alias: PRSS20
alias: Hippostasin
alias: Serine protease 20
alias: Kallikrein-11
title: KLK11
hgnc name: KLK11
URN: urn:edrn:bmdb:biomarker:62
description: The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. Kallikreins are a subgroup of serine proteases having diverse physiological functions. hk11 is a possible multifunctional protease which efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Several human kallikrein genes have been isolated. Expressed in brain, skin and prostate. Isoform 1 is expressed preferentially in brain. Isoform 2 is expressed in prostate.
QA state: Accepted
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/79
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/80
references resource: !/hgnc id/HGNC:6359
references resource: Q9UBX7
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000167757
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/80
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1202
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1203
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/62/29
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/62/58
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/62/1651
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/62/1652

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/943
type: Biomarker
alias: RAB13
alias: growth-inhibiting gene 4 protein
alias: RAS-associated protein RAB13
alias: Cell growth-inhibiting gene 4 protein
alias: RAB13, member RAS oncogene family
alias: cell growth-inhibiting gene 4 protein
alias: ras-related protein Rab-13
title: RAB13
hgnc name: RAB13
URN: urn:edrn:bmdb:biomarker:943
description: RAB13 is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). RAB13 is thought to participate in polarized transport, in the assembly and/or the activity of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. There are several alternatively spliced transcript variants for this gene, and a pseudogene located on chromosome 12.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/5872
references resource: P51153

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/942
type: Biomarker
alias: PTPRE
alias: receptor-type tyrosine-protein phosphatase epsilon
alias: HPTPE
alias: R-PTP-EPSILON
alias: protein tyrosine phosphatase, receptor type, E
alias: Protein-tyrosine phosphatase epsilon
alias: PTPE
alias: R-PTP-epsilon
alias: protein tyrosine phosphatase, receptor type, epsilon polypeptide
alias: EC 3.1.3.48
title: PTPRE
hgnc name: PTPRE
URN: urn:edrn:bmdb:biomarker:942
description: PTPRE is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. The PTPRE gene encodes two isoforms, one of which is a receptor-type PTP, and the other which is not a receptor-type PTP. Both isoforms act as negative regulators of FceRI-mediated signal transduction leading to cytokine production and degranulation.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/5791
references resource: P23469

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/498
type: Biomarker
alias: VEGF
alias: vascular endothelial growth factor A
alias: VEGFA
alias: VEGF-A
alias: VPF
alias: Vascular permeability factor
alias: MVCD1
alias: vascular endothelial growth factor
title: VEGFA
hgnc name: VEGFA
URN: urn:edrn:bmdb:biomarker:498
description: Vascular endothelial growth factor (VEGFA or VEGF) is a growth factor and signaling protein involved in the regulation of angiogenesis, vasculogenesis, and endothelial cell grown. It induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Three VEGFR isoforms have been identified in humans; VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGFR-2 mediates the majority of cellular responses to VEGF. VEGFR-1 is thought to modulate VEGFR-2 signaling or to act as a dummy/decoy receptor to sequester VEGF away from VEGFR-2.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/106
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/233
references resource: !/hgnc id/HGNC:12680
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P15692
references resource: http://www.ncbi.nlm.nih.gov/gene/7422

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/957
type: Biomarker
alias: TLR2
alias: toll-like receptor 2
alias: toll/interleukin-1 receptor-like protein 4
alias: toll/interleukin 1 receptor-like 4
alias: Toll/interleukin-1 receptor-like protein 4
alias: TIL4
alias: CD282 antigen
alias: CD282
title: TLR2
hgnc name: TLR2
URN: urn:edrn:bmdb:biomarker:957
description: TLR2, or toll-like receptor 2, is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR2 is involved in the innate immune response to bacterial lipoproteins and other microbial cell wall components. TLR2 also plays a role in NF-kappa-B activation, cytokine secretion and the inflammatory response.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/228
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/7097
references resource: O60603

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/239
type: Biomarker
alias: IL-8
alias: interleukin 8
alias: IL8
alias: CXCL8
alias: NAF
alias: GCP1
alias: LECT
alias: LUCT
alias: NAP1
alias: GCP-1
alias: LYNAP
alias: MDNCF
alias: MONAP
alias: NAP-1
alias: Granulocyte chemotactic protein
alias: Monocyte-derived neutrophil-activating peptide
alias: C-X-C motif chemokine 8
alias: Neutrophil-activating protein 1
alias: T-cell chemotactic factor
alias: 3-10C
alias: AMCF-I
alias: OTTHUMP00000199825
alias: beta-thromboglobulin-like protein
alias: chemokine (C-X-C motif) ligand 8
alias: emoctakin
alias: interleukin-8
alias: lymphocyte-derived neutrophil-activating factor
alias: neutrophil-activating peptide 1
alias: small inducible cytokine subfamily B, member 8
alias: T cell chemotactic factor
alias: Emoctakin
alias: Protein 3-10C
title: CXCL8
hgnc name: CXCL8
URN: urn:edrn:bmdb:biomarker:239
description: From NCBI Gene: The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/106
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: !/hgnc id/HGNC:6025
references resource: P10145
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000575.1
references resource: https://www.ncbi.nlm.nih.gov/gene/3576

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/946
type: Biomarker
alias: RGS5
alias: MSTP032
alias: MSTP106
alias: MST129
alias: MST092
alias: MSTP092
alias: regulator of G-protein signaling 5
alias: regulator of G-protein signalling 5
alias: MST106
alias: MSTP129
title: RGS5
hgnc name: RGS5
URN: urn:edrn:bmdb:biomarker:946
description: RGS5 is a member of the regulators of G protein signaling (RGS) family, which are signal transduction molecules that are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. RGS5 has been found to be involved in tumor angiogenesis and to antagonize the angiogenic effect of VEGF. Multiple alternatively spliced transcript variants have been found.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8490
references resource: O15539

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/362
type: Biomarker
alias: CDCP1
alias: Q9H5V8
alias: subtractive immunization M plus HEp3-associated 135 kDa protein
alias: Subtractive immunization M plus HEp3-associated 135 kDa protein
alias: SIMA135
alias: CUB domain containing protein 1
alias: membrane glycoprotein gp140
alias: CD318 antigen
alias: TRASK
alias: Transmembrane and associated with src kinases
alias: transmembrane and associated with src kinases
alias: CUB domain-containing protein 1
alias: CD318
alias: Membrane glycoprotein gp140
title: CDCP1
hgnc name: CDCP1
URN: urn:edrn:bmdb:biomarker:362
description: CDCP1 is a transmembrane protein containing three extracellular CUB domains. It is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. CDCP1 is located on the cell surface and may be involved in cell adhesion and cell matrix association. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/64866
references resource: Q9H5V8

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/901
type: Biomarker
alias: CCL28
alias: small inducible cytokine A28
alias: MEC
alias: small inducible cytokine subfamily A (Cys-Cys), member 28
alias: chemokine (C-C motif) ligand 28
alias: Small-inducible cytokine A28
alias: small-inducible cytokine A28
alias: chemokine (C-C motif) ligand 28 splice variant chi
alias: Protein CCK1
alias: mucosae-associated epithelial chemokine
alias: CCK1
alias: C-C motif chemokine 28
alias: SCYA28
alias: CC chemokine CCL28
alias: Mucosae-associated epithelial chemokine
title: CCL28
hgnc name: CCL28
URN: urn:edrn:bmdb:biomarker:901
description: CCL28 is a member of the small cytokine CC subfamily, and is involved in immunoregulatory and inflammatory processes. CC cytokines are characterized by two adjacent cysteines. CCL28 functions as a chemotactic factor for resting CD4 or CD8 T cells and eosinophils. CCL28 binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/56477
references resource: Q9NRJ3

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/865
type: Biomarker
alias: TRADD
alias: TNFR1-associated DEATH domain protein
alias: tumor necrosis factor receptor-1-associated protein
alias: tumor necrosis factor receptor type 1-associated DEATH domain protein
alias: TNFRSF1A-associated via death domain
alias: Hs.89862
alias: tumor necrosis factor receptor type 1 associated death domain protein
alias: TNFR1-associated death domain protein
title: TRADD
hgnc name: TRADD
URN: urn:edrn:bmdb:biomarker:865
description: From NCBI Gene: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: !/hgnc id/HGNC:12030
references resource: https://www.ncbi.nlm.nih.gov/gene/8717
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q15628

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/463
type: Biomarker
alias: Pecot MALDI MS signature + clinical and imaging data
title: Pecot MALDI MS signature + clinical and imaging data
URN: urn:edrn:bmdb:biomarker:463
description: A serum proteomic signature of seven features identified by MALDI MS was previously identified (see "Yildiz MALDI MS signature for lung cancer"). The serum signature was associated with the diagnosis of lung cancer independently of gender, smoking status, smoking pack-years, and C-reactive protein levels. Here the signature is applied to cohorts presenting with one or more lung nodules discovered by clinical evaluation and chest CT.
QA state: Curated
security: Public
type: Proteomic
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/152

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/956
type: Biomarker
alias: STOML2
alias: stomatin-like 2
alias: EPB72-like protein 2
alias: SLP2
alias: stomatin-like protein 2
alias: HSPC108
alias: stomatin (EPB72)-like 2
alias: SLP-2
title: STOML2
hgnc name: STOML2
URN: urn:edrn:bmdb:biomarker:956
description: STOML2, also known as SLP-2 or stomatin-like 2, is a mitochondrial protein that is thought to regulate the biogenesis and the activity of mitochondria, and through this regulation play a role in cell activities such as cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/227
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/30968
references resource: Q9UJZ1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/238
type: Biomarker
alias: IL6
alias: interleukin 6 (interferon, beta 2)
alias: IL-6
alias: BSF2
alias: HGF
alias: HSF
alias: IFNB2
alias: Hybridoma growth factor
alias: Interferon beta-2
alias: BSF-2
alias: CDF
alias: IFN-beta-2
alias: B-cell stimulatory factor 2
alias: CTL differentiation factor
alias: B cell stimulatory factor-2
alias: B-cell differentiation factor
alias: Interleukin 6
title: IL6
hgnc name: IL6
URN: urn:edrn:bmdb:biomarker:238
description: Interleukin 6 (IL6) is a cytokine that is involved in inflammation and the maturation of B cells as well as induction of the acute phase response. In addition to inducing myeloma and plasmacytoma growth and nerve cell differentiation, it also plays an important role in the differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. The IL6 protein is produced mainly at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The IL6 gene is involved in many inflammation-associated disease states, including diabetes mellitus, where it acts on insulin resistance, and systemic juvenile rheumatoid arthritis. IL6 is discharged into the bloodstream after muscle contraction.
QA state: Curated
security: Public
type: Proteomic
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/176
references resource: !/hgnc id/HGNC:6018
references resource: P05231
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000591.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/80
type: Biomarker
alias: leptin
alias: LEP
alias: OB
alias: OBS
alias: FLJ94114
alias: obesity factor
alias: leptin (murine obesity homolog)
alias: obese, mouse, homolog of
alias: leptin (obesity homolog, mouse)
title: LEP
hgnc name: LEP
URN: urn:edrn:bmdb:biomarker:80
description: Leptin (LEP) is secreted by white adipocytes and plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. Leptin has also been implicated in the regulation of reproduction, glucose homeostasis, bone formation, wound healing and the immune system. Leptin has several endocrine functions and is also involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in the leptin gene and/or its regulatory regions cause severe obesity and morbid obesity with hypogonadism. The leptin gene has also been linked to type 2 diabetes mellitus development.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Mor Yale University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/222
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/254
references resource: !/hgnc id/HGNC:6553
references resource: P41159
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000221.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/950
type: Biomarker
alias: SLC25A16
alias: ML7
alias: solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
alias: HGT.1
alias: hML7
alias: GDA
alias: mitochondrial solute carrier protein homolog
alias: D10S105E
alias: solute carrier family 25 member 16
alias: Graves disease autoantigen
alias: graves disease carrier protein
alias: GDC
alias: Solute carrier family 25 member 16
alias: Mitochondrial solute carrier protein homolog
alias: graves disease autoantigen
title: SLC25A16
hgnc name: SLC25A16
URN: urn:edrn:bmdb:biomarker:950
description: SLC25A16 is a member of the mitochondrial carrier family and contains three tandemly repeated mitochondrial carrier protein domains. The SLC26A16 protein is found in the inner membrane of the mitochondria where it is necessary for the accumulation of coenzyme A in the mitochondrial matrix. SLC25A16 also facilitates the rapid transport and exchange of molecules between the cytosol and the mitochondrial matrix space. The SLC25A16 gene is thought to be involved in Graves' disease.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8034
references resource: P16260

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/935
type: Biomarker
alias: PDGF
alias: Platelet-derived growth factor
alias: PDGFA
alias: platelet-derived growth factor alpha polypeptide
title: PDGFA
hgnc name: PDGFA
URN: urn:edrn:bmdb:biomarker:935
description: PDGFA, or platelet-derived growth factor alpha polypeptide, is a member of the platelet-derived growth factor family. PDGFA is a growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. There are four members of the PDGF family, characterized by a motif of eight cysteines. PDGFA exists as either a homodimer or a heterodimer with PDGFB (platelet-derived growth factor beta polypeptide).
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/5154
references resource: P04085

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/922
type: Biomarker
alias: ITGB1
alias: VLAB
alias: VLA-4 subunit beta
alias: integrin VLA-4 beta subunit
alias: CD29
alias: integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
alias: CD29 antigen
alias: GPIIA
alias: FNRB
alias: VLA-BETA
alias: MSK12
alias: MDF2
alias: very late activation protein, beta polypeptide
alias: Fibronectin receptor subunit beta
alias: integrin beta-1
title: ITGB1
hgnc name: ITGB1
URN: urn:edrn:bmdb:biomarker:922
description: ITGB1 is a beta subunit of the heterodimeric integrin protein. Integrins are ubiquitously expressed adhesion molecules composed of alpha and beta subunits. In mammals, 18 alpha and 8 beta subunits have been identified. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Several protein isoforms have been identifed, arising from alternatively spliced transcript variants.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/3688
references resource: P05556

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/936
type: Biomarker
alias: PEX11B
alias: peroxin-11B
alias: PEX11-beta
alias: Peroxisomal biogenesis factor 11B
alias: Protein PEX11 homolog beta
alias: peroxisomal membrane protein 11B
alias: peroxisomal biogenesis factor 11 beta
alias: peroxisomal biogenesis factor 11B
alias: PEX11-BETA
alias: Peroxin-11B
alias: protein PEX11 homolog beta
title: PEX11B
hgnc name: PEX11B
URN: urn:edrn:bmdb:biomarker:936
description: PEX11B, or peroxisomal biogenesis factor 11 beta, is involved in peroxisomal proliferation and interacts with PEX19. PEX11B is located in the peroxisomal membrane and is thought to regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8799
references resource: O96011

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/945
type: Biomarker
alias: RANTES
alias: CCL5
alias: T-cell-specific protein RANTES
alias: D17S136E
alias: SCYA5
alias: Small-inducible cytokine A5
alias: small inducible cytokine A5 (RANTES)
alias: small-inducible cytokine A5
alias: T cell-specific protein P228
alias: chemokine (C-C motif) ligand 5
alias: Eosinophil chemotactic cytokine
alias: MGC17164
alias: beta-chemokine RANTES
alias: small inducible cytokine subfamily A (Cys-Cys), member 5
alias: eosinophil chemotactic cytokine
alias: T-cell specific protein p288
alias: EoCP
alias: t cell-specific protein P228
alias: eoCP
alias: TCP228
alias: SISd
alias: regulated upon activation, normally T-expressed, and presumably secreted
alias: SIS-delta
alias: C-C motif chemokine 5
title: CCL5
hgnc name: CCL5
URN: urn:edrn:bmdb:biomarker:945
description: From NCBI Gene: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/223
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6352
references resource: P13501

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/965
type: Biomarker
alias: ZFP36L1
alias: butyrate response factor 1
alias: ERF1
alias: zinc finger protein, C3H type, 36-like 1
alias: zinc finger protein 36, C3H1 type-like 1
alias: early response factor Berg36
alias: TIS11B
alias: EGF-response factor 1
alias: Butyrate response factor 1
alias: BERG36
alias: ERF-1
alias: cMG1
alias: zinc finger protein 36, C3H type-like 1
alias: Protein TIS11B
alias: Berg36
alias: RNF162B
alias: BRF1
title: ZFP36L1
hgnc name: ZFP36L1
URN: urn:edrn:bmdb:biomarker:965
description: ZFP36L1 is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The ZFP36L1 gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. ZFP36L1 contains a putative zinc finger domain with a repeating cys-his motif. ZFP36L1 is believed to be a nuclear transcription factor most likely functioning in regulating the response to growth factors. Different isoforms encoded by alternatively spliced transcript variants have been isolated.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/677
references resource: Q07352

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/542
type: Biomarker
alias: CALCA
alias: Calcitonin-Related Polypeptide Alpha
alias: CALC1
alias: Calcitonin 1
alias: Alpha-Type CGRP
alias: Calcitonin Gene-Related Peptide I
alias: CGRP-1
alias: CGRP
alias: CGRP1
alias: CT
alias: KC
alias: Calcitonin
alias: Calcitonin/Calcitonin-Related Polypeptide, Alpha
alias: Katacalcin
title: CALCA
hgnc name: CALCA
URN: urn:edrn:bmdb:biomarker:542
description: From NCBI Gene: This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/128
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/796
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P06881

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/191
type: Biomarker
alias: ESM1
alias: endothelial cell-specific molecule 1
alias: ESM-1
alias: endocan
title: ESM1
hgnc name: ESM1
URN: urn:edrn:bmdb:biomarker:191
description: ESM1, a secreted protein containing multiple polyadenylation and mRNA instability signals, may have potent implications in lung endothelial cell-leukocyte interactions. It is expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney. The expression of the ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Two transcript variants encoding different isoforms have been found for this gene.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/11082
references resource: Q9NQ30

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/229
type: Biomarker
alias: GH1
alias: Somatotropin
alias: Growth hormone
alias: GH
alias: GH-N
alias: Growth hormone 1
alias: Pituitary growth hormone
alias: growth hormone 1
alias: GHN
alias: hGH-N
alias: pituitary growth hormone
alias: IGHD1B
title: GH1
hgnc name: GH1
URN: urn:edrn:bmdb:biomarker:229
description: Growth hormone, a secreted protein which exists as a monomer, dimer, trimer, tetramer and pentamer and is disulfide-linked or non-covalently associated in homopolymeric and heteropolymeric combinations, plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. GH belongs to the somatotropin/prolactin family.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:4261
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P01241
references resource: ENSG00000259384
references resource: http://www.ncbi.nlm.nih.gov/gene/2688

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/540
type: Biomarker
alias: MCAM
alias: Gicerin
alias: melanoma-associated antigen A32
alias: melanoma cell adhesion molecule
alias: CD146 antigen
alias: cell surface glycoprotein MUC18
alias: S-endo 1 endothelial-associated antigen
alias: Melanoma-associated antigen MUC18
alias: cell surface glycoprotein P1H12
alias: melanoma adhesion molecule
alias: Cell surface glycoprotein P1H12
alias: CD146
alias: MUC18
alias: Melanoma cell adhesion molecule
alias: melanoma-associated antigen MUC18
alias: Melanoma-associated antigen A32
title: MCAM
hgnc name: MCAM
URN: urn:edrn:bmdb:biomarker:540
description: From UniProtKB/Swiss-Prot: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
QA state: Curated
phase: 1
security: Public
type: Glycomic
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/128
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/4162
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P43121

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1011
type: Biomarker
alias: HIST1H2BG
alias: Histone H2B.1 A
alias: Histone 1, H2bg
alias: Histone Cluster 1, H2bg
alias: Histone H2B Type 1-C/E/F/G/I
alias: H2B Histone Family, Member A
alias: Histone Cluster 1 H2B Family Member G
alias: H2BFA
alias: H2B.1A
alias: H2B/A
alias: H2B Clustered Histone 8
alias: H2BC8
alias: Histone H2B.A
alias: Histone H2B.G
alias: Histone H2B.H
alias: Histone H2B.K
alias: Histone H2B.L
alias: DJ221C16.8
alias: HIST1H2BC
alias: HIST1H2BE
alias: HIST1H2BF
alias: HIST1H2BI
alias: H2BC10
alias: H2BC4
alias: H2BC6
alias: H2BC7
alias: H2BFL
alias: H2BFH
alias: H2BFG
alias: H2BFK
alias: H2B/G
alias: H2B/H
alias: H2B/K
alias: H2B/L
title: H2BC8
hgnc name: H2BC8
URN: urn:edrn:bmdb:biomarker:1011
description: This gene was formerly known as HIST1H2BG. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: !/hgnc id/HGNC:4746
references resource: http://www.ncbi.nlm.nih.gov/gene/8339
references resource: P62807
references resource: http://omim.org/entry/602798
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/21
type: Biomarker
alias: KLK-6
alias: Kallikrein-6
alias: HK-6
alias: Protease M
alias: Neurosin
alias: Serine protease 9
alias: Serine protease 18
alias: Zyme
alias: SP59
alias: Bssp
alias: PRSS9
alias: PRSS18
alias: KLK6
alias: kallikrein-related peptidase 6
alias: Klk7
title: KLK6
hgnc name: KLK6
URN: urn:edrn:bmdb:biomarker:21
description: Serine protease M expressed on epithelial cell surface and released in ECM. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
QA state: Accepted
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Cramer Brigham and Women's Hospital
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/9
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/191
references resource: !/hgnc id/HGNC:6367
references resource: http://www.expasy.org/cgi-bin/niceprot.pl
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000167755
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/42
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1199
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/21/15
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/21/43
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/21/1006
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/21/1648

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/924
type: Biomarker
alias: JUNB
alias: transcription factor jun-B
alias: AP-1
alias: activator protein 1
alias: jun B proto-oncogene
title: JUNB
hgnc name: JUNB
URN: urn:edrn:bmdb:biomarker:924
description: JUNB, or jun B proto-oncogene, is a transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/219
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/3726
references resource: http://www.uniprot.org/uniprot/

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/163
type: Biomarker
alias: LTBP2
alias: latent transforming growth factor beta binding protein 2
alias: LTBP3
alias: C14orf141
alias: chromosome 14 open reading frame 141
alias: GLC3D
alias: MSTP031
alias: LTBP-2
alias: Latent-transforming growth factor beta-binding protein 2
title: LTBP2
hgnc name: LTBP2
URN: urn:edrn:bmdb:biomarker:163
description: LTBP2, the largest member of the latent transforming growth factor (TGF)-beta binding protein family, possesses unique regions and is most similar to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. LTBP2 forms part of the large latent transforming growth factor beta precursor complex; removal is essential for activation of complex. It is expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Diamandis Mount Sinai Hospital
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/4053
references resource: Q14767

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/228
type: Biomarker
alias: FSHB
alias: follicle stimulating hormone, beta polypeptide
alias: follicle-stimulating hormone beta subunit
alias: follitropin, beta chain
alias: Follitropin subunit beta
alias: FSH-B
alias: FSH-beta
alias: Follitropin beta chain
alias: FSH
title: FSH
hgnc name: FSHB
URN: urn:edrn:bmdb:biomarker:228
description: The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] Defects in FSHB are a cause of isolated follicle-stimulating hormone deficiency. Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. FSHB belongs to the glycoprotein hormones subunit beta family. There are two transcript variants from alternative splicing that each encode the same protein.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/172
references resource: !/hgnc id/HGNC:3964
references resource: P01225
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000501.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/375
type: Biomarker
alias: FZD10
alias: Q9ULW2
alias: hFz10
alias: frizzled-10
alias: CD350
alias: frizzled 10, seven transmembrane spanning receptor
alias: frizzled (Drosophila) homolog 10
alias: CD350 antigen
alias: Fz10
alias: Fz-10
alias: FZ-10
alias: frizzled homolog 10
alias: frizzled family receptor 10
alias: frizzled homolog 10 (Drosophila)
alias: FzE7
title: FZD10
hgnc name: FZD10
URN: urn:edrn:bmdb:biomarker:375
description: FZD10 is a member of the frizzled gene family. The frizzled gene family encodes 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins (WNT signaling proteins). The highest levels of expression for FZD10 are seen in the placenta and fetal kidney, followed by fetal lung and brain. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/196
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/11211
references resource: Q9ULW2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/360
type: Biomarker
alias: c11orf8
alias: Q15777
alias: MPPED2
alias: dJ1024C24.1
alias: FAM1B
alias: 239FB
alias: Fetal brain protein 239
alias: chromosome 11 open reading frame 8
alias: metallophosphoesterase domain containing 2
alias: Hs.46638
alias: metallophosphoesterase MPPED2
alias: D11S302E
alias: C11orf8
alias: Metallophosphoesterase domain-containing protein 2
alias: dJ873F21.1
alias: fetal brain protein 239
alias: metallophosphoesterase domain-containing protein 2
alias: EC 3.1.-.-
title: MPPED2
hgnc name: MPPED2
URN: urn:edrn:bmdb:biomarker:360
description: From NCBI Gene: This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/212
references resource: !/hgnc id/HGNC:1180
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/744
references resource: Q15777

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/929
type: Biomarker
alias: MCP-1
alias: CCL2
alias: monocyte secretory protein JE
alias: MCP1
alias: Monocyte chemotactic and activating factor
alias: monocyte chemoattractant protein 1
alias: chemokine (C-C motif) ligand 2
alias: small-inducible cytokine A2
alias: MGC9434
alias: monocyte chemoattractant protein-1
alias: Monocyte chemoattractant protein 1
alias: SMC-CF
alias: monocyte chemotactic protein 1
alias: Monocyte chemotactic protein 1
alias: SCYA2
alias: GDCF-2
alias: MCAF
alias: C-C motif chemokine 2
alias: Small-inducible cytokine A2
alias: Monocyte secretory protein JE
alias: small inducible cytokine subfamily A (Cys-Cys), member 2
alias: monocyte chemotactic and activating factor
alias: HC11
alias: HSMCR30
alias: small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je)
title: CCL2
hgnc name: CCL2
URN: urn:edrn:bmdb:biomarker:929
description: From NCBI Gene: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013]
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6347
references resource: P13500

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/886
type: Biomarker
alias: YWHAE
alias: 14-3-3E
alias: protein kinase C inhibitor protein-1
alias: tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide
alias: 14-3-3 epsilon
alias: MDS
alias: 14-3-3 protein epsilon
alias: MDCR
alias: FLJ45465
alias: KCIP-1
alias: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
alias: mitochondrial import stimulation factor L subunit
title: YWHAE
hgnc name: YWHAE
URN: urn:edrn:bmdb:biomarker:886
description: From NCBI Gene: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/7531
references resource: P62258
references resource: http://www.omim.org/entry/605066

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/646
type: Biomarker
alias: ERBB3
alias: HER3
alias: p180-ErbB3
alias: p45-sErbB3
alias: Proto-oncogene-like protein c-ErbB-3
alias: ErbB-3
alias: v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
alias: erbB3-S
alias: c-erbB-3
alias: Tyrosine kinase-type cell surface receptor HER3
alias: LCCS2
alias: lethal congenital contracture syndrome 2
alias: MDA-BF-1
alias: tyrosine kinase-type cell surface receptor HER3
alias: receptor tyrosine-protein kinase erbB-3
alias: p85-sErbB3
alias: proto-oncogene-like protein c-ErbB-3
alias: c-erbB3
alias: EC 2.7.10.1
title: ERBB3
hgnc name: ERBB3
URN: urn:edrn:bmdb:biomarker:646
description: From NCBI Gene: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/2065
references resource: P21860
references resource: http://omim.org/entry/190151

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/390
type: Biomarker
alias: SCGB2A1
alias: O75556
alias: lipophilin-C
alias: mammaglobin-2
alias: Secretoglobin family 2A member 1
alias: UGB3
alias: secretoglobin, family 2A, member 1
alias: Mammaglobin-2
alias: MGB2
alias: lipophilin C
alias: LPHC
alias: lacryglobin
alias: mammaglobin B
alias: mammaglobin-B
alias: mammaglobin 2
alias: Lacryglobin
alias: LIPHC
alias: MGC71973
alias: Lipophilin-C
title: SCGB2A1
hgnc name: SCGB2A1
URN: urn:edrn:bmdb:biomarker:390
description: SCGB2A1, also known as MGB2 or mammaglobin B, encodes a small secreted protein from the secretoglobin family, part of the uterglobin superfamily. SCGB2A1 is normally expressed in the thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/196
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/200
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/201
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:7051
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/4246
references resource: O75556

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/951
type: Biomarker
alias: SNRPA1
alias: small nuclear ribonucleoprotein polypeptide A'
alias: U2 small nuclear ribonucleoprotein A'
alias: U2 snRNP A'
alias: U2 small nuclear ribonucleoprotein polypeptide A'
alias: Lea1
title: SNRPA1
hgnc name: SNRPA1
URN: urn:edrn:bmdb:biomarker:951
description: SNRPA1 is a nuclear protein associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. SNRPA1 has four LRR (leucine-rich) repeats and one LRRCT domain.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6627
references resource: P09661

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/938
type: Biomarker
alias: PTCHD1
alias: patched domain-containing protein 1
alias: FLJ30296
alias: patched domain containing 1
title: PTCHD1
hgnc name: PTCHD1
URN: urn:edrn:bmdb:biomarker:938
description: PTCHD1 is a membrane protein with a patched domain that is similar to Drosophila proteins which act as receptors for the morphogen sonic hedgehog. Deletions in the PTCHD1 gene, which is located on the X chromosome, are associated with intellectual disability and autism spectrum disorder.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/139411
references resource: Q96NR3

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/391
type: Biomarker
alias: SDC1
alias: P18827
alias: syndecan 1
alias: SDC
alias: CD138
alias: syndecan
alias: CD138 antigen
alias: heparan sulfate proteoglycan fibroblast growth factor receptor
alias: syndecan proteoglycan 1
alias: syndecan-1
title: SDC1
hgnc name: SDC1
URN: urn:edrn:bmdb:biomarker:391
description: SDC1 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The SDC1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6382
references resource: P18827

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/384
type: Biomarker
alias: LGALS3BP
alias: Q08380
alias: Tumor-associated antigen 90K
alias: M2BP
alias: 90K
alias: mac-2 BP
alias: basement membrane autoantigen p105
alias: galectin-3-binding protein
alias: MAC2BP
alias: L3 antigen
alias: Basement membrane autoantigen p105
alias: MAC-2-BP
alias: Mac-2 BP
alias: Mac-2-binding protein
alias: BTBD17B
alias: tumor-associated antigen 90K
alias: lectin galactoside-binding soluble 3-binding protein
alias: lectin, galactoside-binding, soluble, 3 binding protein
alias: serum protein 90K
alias: Lectin galactoside-binding soluble 3-binding protein
title: LGALS3BP
hgnc name: LGALS3BP
URN: urn:edrn:bmdb:biomarker:384
description: From NCBI Gene: he galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:6564
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/3959
references resource: Q08380

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/38
type: Biomarker
alias: PGP9.5
alias: UCHL1
alias: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
alias: Uch-L1
alias: PARK5
alias: Neuron cytoplasmic protein 9.5
alias: UCH-L1
alias: Ubiquitin thioesterase L1
alias: PGP 9.5
alias: PGP95
alias: ubiquitin C-terminal hydrolase
alias: ubiquitin carboxyl-terminal hydrolase isozyme L1
title: UCHL1
hgnc name: UCHL1
URN: urn:edrn:bmdb:biomarker:38
description: PGP9.5, also called Ubiquitin-protein hydrolase (UCHL1), is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Oxidation of Met-1, Met-6, Met-12, Met-124 and Met-179 to methionine sulfoxide, and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. PGP9.5 has been proposed as a marker with a potential role in carcinogenesis.
QA state: Accepted
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Hanash Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/26
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/27
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/39
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/40
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/41
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/73
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/75
references resource: P09936
references resource: !/hgnc id/HGNC:12513
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000154277
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/59
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/38/999

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/671
type: Biomarker
alias: GADD45B
alias: growth arrest and DNA-damage-inducible, beta
alias: Myeloid differentiation primary response protein MyD118
alias: MYD118
alias: Negative growth regulatory protein MyD118
alias: DKFZP566B133
alias: myeloid differentiation primary response protein MyD118
alias: growth arrest and DNA damage-inducible protein GADD45 beta
alias: GADD45BETA
alias: negative growth regulatory protein MyD118
title: GADD45B
hgnc name: GADD45B
URN: urn:edrn:bmdb:biomarker:671
description: From NCBI Gene: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/search
references resource: http://www.ncbi.nlm.nih.gov/gene/4616
references resource: O75293
references resource: http://omim.org/entry/604948

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1078
type: Biomarker
alias: Mitochondrial Genome Deletion for Detection of Prostate Cancer
alias: Prostate Core Mitomic Test™
alias: Mitochondrial deletion for detection of prostate cancer
alias: Prostate Core Mitomic Test
title: Mitochondrial Genome Deletion for Detection of Prostate Cancer
URN: urn:edrn:bmdb:biomarker:1078
description: The Prostate Core Mitomic Test is based upon a 3.4 kb mitochondrial genome deletion (3.4 mtdelta) that was identified through PCR analysis of frozen prostate cancer samples. In cancer research it has been found that deletions in mitochondrial DNA can correlate with cellular changes that indicate development of cancer. This deletion includes the terminal 22 bases of MT-ND4L, all of MT-ND4, 3 tRNAs (histidine, serine 2, and leucine 2), and all except the terminal 24 bases of MT-ND5.
QA state: Curated
security: Public
type: Genomic
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/237
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/275
references resource: healthcare-professionals.php

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/554
type: Biomarker
alias: Bajtarevic VOCs signature
title: Bajtarevic VOCs signature
URN: urn:edrn:bmdb:biomarker:554
description: Exhaled breath was collected and differences in concentration for more than 50 volatile organic compounds (VOCs) was assayed by various methods.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/158

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/36
type: Biomarker
alias: Alpha-fetoglobulin
alias: AFP
alias: FETA
alias: Alpha-1-fetoprotein
alias: Alpha-fetoprotein
alias: HPAFP
alias: HP
title: AFP
hgnc name: AFP
URN: urn:edrn:bmdb:biomarker:36
description: From NCBI Gene: This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Instititute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/33
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/132
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: !/hgnc id/HGNC:317
references resource: P02771
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 001125.1
references resource: ucm078610.htm

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/944
type: Biomarker
alias: RAB24
alias: RAB24, member RAS oncogene family
alias: ras-related protein Rab-24
title: RAB24
hgnc name: RAB24
URN: urn:edrn:bmdb:biomarker:944
description: RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking. RAB24 may be involved in autophagy-related processes.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/53917
references resource: Q969Q5

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1125
type: Biomarker
alias: EsoGuard
alias: EsoCheck
title: EsoGuard
URN: urn:edrn:bmdb:biomarker:1125
description: EsoCheck is used to collect esophageal cells. The EsGuard DNA test is then used to detect Barrett's esophagus or esophageal adenocarcinoma by analyzing methylation on the VIM and CCNA1 genes. From Esoguard.com: With over 90% sensitivity and specificity at detecting BE and EAC, the EsoGuard esophageal DNA test allows detection of these conditions in a simple office-based procedure WITHOUT endoscopy. EsoGuard analyzes methylation at 31 sites on 2 genes. From https://www.luciddx.com/esocheck: EsoCheck is a cell collection device that is designed to collect cells of a targeted region of the esophagus without the need for endoscopy. The sampled cells can then be subjected to any commercially available diagnostic test.
QA state: Curated
security: Public
type: Epigenetic
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: G.I. and Other Associated
access granted to: Markowitz Case Western Reserve University
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/178
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/283
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/289
references resource: lucid-diagnostics
references resource: www.esoguard.com

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/557
type: Biomarker
alias: ACO1
alias: Iron regulatory protein 1
alias: iron-responsive element-binding protein 1
alias: IRE-BP 1
alias: IRP1
alias: IREBP
alias: aconitate hydratase
alias: IREBP1
alias: iron-responsive element binding protein 1
alias: Aconitase
alias: Ferritin repressor protein
alias: cytoplasmic aconitate hydratase
alias: IREB1
alias: iron regulatory protein 1
alias: Iron-responsive element-binding protein 1
alias: aconitase 1, soluble
alias: ferritin repressor protein
alias: Citrate hydro-lyase
alias: ACONS
alias: citrate hydro-lyase
alias: EC 4.2.1.3
title: ACO1
hgnc name: ACO1
URN: urn:edrn:bmdb:biomarker:557
description: From NCBI Gene: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1261
type: Biomarker
alias: SPARC2
title: SPARC2
URN: urn:edrn:bmdb:biomarker:1261
QA state: New
security: Public
type: Proteomic
is panel: 0

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/923
type: Biomarker
alias: ITGBL1
alias: integrin, beta-like 1 (with EGF-like repeat domains)
alias: Osteoblast-specific cysteine-rich protein
alias: integrin beta-like protein 1
alias: ten integrin EGF-like repeat domains protein
alias: ten integrin EGF-like repeat domain-containing protein
alias: TIED
alias: Ten integrin EGF-like repeat domain-containing protein
alias: OSCP
alias: osteoblast-specific cysteine-rich protein
title: ITGBL1
hgnc name: ITGBL1
URN: urn:edrn:bmdb:biomarker:923
description: ITGBL1, or integrin, beta-like 1 (with EGF-like repeat domains), is a member of the EGF-like protein family. It is a beta integrin-related protein containing integrin-like cysteine-rich repeats. Multiple transcript variants result from alternative splicing.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/9358
references resource: O95965
references resource: http://www.genenames.org/cgi-bin/search

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/388
type: Biomarker
alias: PCDH17
alias: O14917
alias: protocadherin-17
alias: protocadherin 68
alias: Protocadherin-68
alias: protocadherin 17
alias: protocadherin-68
alias: PCH68
alias: PCDH68
title: PCDH17
hgnc name: PCDH17
URN: urn:edrn:bmdb:biomarker:388
description: From NCBI Gene: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:14267
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/27253
references resource: O14917

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/451
type: Biomarker
alias: Yildiz MALDI MS signature for lung cancer
title: Yildiz MALDI MS signature for lung cancer
URN: urn:edrn:bmdb:biomarker:451
description: A serum proteomic signature of seven features identified by MALDI MS has been identified. The serum signature was associated with the diagnosis of lung cancer independently of gender, smoking status, smoking pack-years, and C-reactive protein levels.
QA state: Curated
security: Public
type: Proteomic
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/151

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/396
type: Biomarker
alias: TNFAIP1
alias: Q13829
alias: tumor necrosis factor, alpha-induced protein 1
alias: B12
alias: B61
alias: MGC2317
alias: EDP1
alias: BTB/POZ domain-containing protein TNFAIP1
alias: hBACURD2
alias: OTTHUMP00000163324
alias: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation
alias: protein 2
alias: BACURD2
alias: Protein B12
alias: Tumor necrosis factor, alpha-induced protein 1, endothelial
title: TNFAIP1
hgnc name: TNFAIP1
URN: urn:edrn:bmdb:biomarker:396
description: From NCBI Gene: This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/7126
references resource: Q13829

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/906
type: Biomarker
alias: CSRP2
alias: LMO5
alias: Cysteine-rich protein 2
alias: LMO-5
alias: Smooth muscle cell LIM protein
alias: LIM domain only 5, smooth muscle
alias: SMLIM
alias: cysteine and glycine-rich protein 2
alias: LIM domain only protein 5
alias: SmLIM
alias: smooth muscle cell LIM protein
alias: cysteine-rich protein 2
alias: CRP2
title: CSRP2
hgnc name: CSRP2
URN: urn:edrn:bmdb:biomarker:906
description: CSRP2 encodes a LIM domain protein. LIM domain proteins may be involved in regulatory processes important for development and cellular differentiation. CSRP2 has two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. CSRP2 is thought to play a role in the development of the embryonic vascular system.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/1466
references resource: Q16527

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/961
type: Biomarker
alias: UPP1
alias: UP
alias: UPP
alias: uridine phosphorylase 1
alias: urdPase 1
alias: UPase 1
alias: UPASE
alias: UDRPASE
alias: UrdPase 1
alias: uridine phosphorylase
alias: EC 2.4.2.3
title: UPP1
hgnc name: UPP1
URN: urn:edrn:bmdb:biomarker:961
description: UPP1, or uridine phosphorylase 1, is a pyrimidine nucleoside phosphorylase. UPP1, in the presence of orthophosphate, catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/7378
references resource: Q16831

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/947
type: Biomarker
alias: RHOA
alias: RhoA
alias: Rho cDNA clone 12
alias: rho cDNA clone 12
alias: ras homolog family member A
alias: RHOH12
alias: ras homolog gene family, member A
alias: h12
alias: transforming protein RhoA
alias: small GTP binding protein RhoA
alias: ARH12
alias: oncogene RHO H12
alias: ARHA
alias: Aplysia ras-related homolog 12
alias: RHO12
alias: Rho12
title: RHOA
hgnc name: RHOA
URN: urn:edrn:bmdb:biomarker:947
description: RHOA is a member of the small GTPase superfamily. RHO family GTPases are involved in many basic cellular processes that influence cell proliferation, differentiation, motility, adhesion, survival, or secretion. RHOA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/225
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/387
references resource: P61586

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/499
type: Biomarker
alias: Philips VOCs signature
title: Philips VOCs signature
URN: urn:edrn:bmdb:biomarker:499
description: A combination of 22 breath volatile organic compounds (VOCs), predominantly alkanes, alkane derivatives, and benzene derivatives, that can discriminate between patients with and without lung cancer, regardless of stage (all p<0.0003).
QA state: Curated
security: Public
type: Metabolomic
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/157

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/358
type: Biomarker
alias: ADAM12
alias: O43184
alias: ADAM 12
alias: MLTNA
alias: a disintegrin and metalloproteinase domain 12 (meltrin alpha)
alias: disintegrin and metalloproteinase domain-containing protein 12
alias: meltrin-alpha
alias: MCMPMltna
alias: MCMP
alias: Meltrin-alpha
alias: ADAM metallopeptidase domain 12
alias: MLTN
alias: EC 3.4.24.-
title: ADAM12
hgnc name: ADAM12
URN: urn:edrn:bmdb:biomarker:358
description: From NCBI Gene: This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:190
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8038
references resource: O43184
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/363
type: Biomarker
alias: CMKOR1
alias: P25106
alias: CXCR7
alias: chemokine (C-X-C motif) receptor 7
alias: chemokine orphan receptor 1
alias: CXCR-7
alias: CXC-R7
alias: Chemokine orphan receptor 1
alias: G protein-coupled receptor
alias: GPR159
alias: RDC-1
alias: G-protein coupled receptor RDC1 homolog
alias: RDC1
alias: G-protein coupled receptor 159
alias: C-X-C chemokine receptor type 7
alias: ACKR3
title: ACKR3
hgnc name: ACKR3
URN: urn:edrn:bmdb:biomarker:363
description: From NCBI Gene: This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/57007
references resource: P25106
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/101
type: Biomarker
alias: ICAM1
alias: intercellular adhesion molecule 1
alias: BB2
alias: CD54
alias: Major group rhinovirus receptor
alias: ICAM-1
alias: Cell Surface Glycoprotein P3.58
alias: Human Rhinovirus Receptor
alias: CD54 Antigen
alias: P3.58
title: ICAM1
hgnc name: ICAM1
URN: urn:edrn:bmdb:biomarker:101
description: From NCBI Gene: This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Hanash Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Instititute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:5344
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P05362
references resource: ENSG00000090339
references resource: http://www.ncbi.nlm.nih.gov/gene/3383

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/953
type: Biomarker
alias: SSBP1
alias: SSBP
alias: Mt-SSB
alias: SOSS-B1
alias: single-stranded DNA-binding protein, mitochondrial
alias: single-stranded DNA binding protein 1, mitochondrial
alias: single-stranded DNA binding protein 1
alias: PWP1-interacting protein 17
alias: mtSSB
alias: MtSSB
alias: single-stranded DNA-binding protein
title: SSBP1
hgnc name: SSBP1
URN: urn:edrn:bmdb:biomarker:953
description: SSBP1 is a housekeeping gene that is thought to be involved in mitochondrial DNA replication. SSBP1, or single-stranded DNA-binding protein binds to single stranded DNA. It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6742
references resource: Q04837

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/242
type: Biomarker
alias: interleukin 2 receptor, alpha
alias: IL2RA
alias: CD25
alias: IL-2-RA
alias: IL2-RA
alias: IL-2 receptor subunit alpha
alias: IL-2R subunit alpha
alias: p55
alias: TAC antigen
alias: IDDM10
alias: IL2R
alias: OTTHUMP00000019031
alias: TCGFR
alias: interleukin-2 receptor subunit alpha
alias: CD25 antigen
title: IL2RA
hgnc name: IL2RA
URN: urn:edrn:bmdb:biomarker:242
description: The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of IL2RA, the alpha subunit. The alpha/beta subunit heterodimer, formed by IL2RA and IL2RB, is an intermediate affinity form. The alpha/beta/gamma heterotrimer formed by IL2RA, IL2RB, and IL2RG is the high affinity form. IL2RA is normally an integral membrane protein, although soluble IL2RA has been isolated. There are known alternately-spliced versions of IL2RA mRNAs, but their functions are unknown. Mutations in the IL2RA gene are associated with diabetes mellitus insulin-dependent type 10 (IDDM10). Complications of IDDM10 can adversely affect the eyes, kidneys, nerves, and blood vessels.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:6008
references resource: P01589
references resource: ENSG00000134460
references resource: NP 000408.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/361
type: Biomarker
alias: C6ORF55
alias: Q9NP79
alias: VTA1
alias: dopamine-responsive gene 1 protein
alias: Vps20-associated 1 homolog (S. cerevisiae)
alias: Dopamine-responsive gene 1 protein
alias: LYST-interacting protein 5
alias: HSPC228
alias: SKD1-binding protein 1
alias: homolog of mouse SKD1-binding protein 1
alias: DRG1
alias: LIP5
alias: SBP1
alias: chromosome 6 open reading frame 55
alias: DRG-1
alias: My012
alias: vacuolar protein sorting-associated protein VTA1 homolog
alias: C6orf55
title: VTA1
hgnc name: VTA1
URN: urn:edrn:bmdb:biomarker:361
description: VTA1 (C6ORF55) is involved in activities of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes. VTA1 is thought to be a cofactor of VPS4A/B. VTA1 is involved in HIV-1 budding. It has been shown by similarity to be involved in the sorting and down-regulation of EGFR.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/51534
references resource: Q9NP79

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/939
type: Biomarker
alias: PTPMT1
alias: Phosphoinositide lipid phosphatase
alias: MOSP
alias: phosphoinositide lipid phosphatase
alias: protein-tyrosine phosphatase mitochondrial 1
alias: protein tyrosine phosphatase, mitochondrial 1
alias: PLIP
alias: NB4 apoptosis/differentiation related protein
alias: PTEN-like phosphatase
alias: DUSP23
alias: EC 3.1.3.16,EC 3.1.3.48
title: PTPMT1
hgnc name: PTPMT1
URN: urn:edrn:bmdb:biomarker:939
description: PTPMT1 is a lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/114971
references resource: Q8WUK0

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1553
type: Biomarker
alias: PRNP
alias: Prion Protein
alias: AltPrP
alias: CD230
alias: PRIP
alias: PRP
alias: Alternative Prion Protein
alias: Major Prion Protein
alias: CD230 Antigen
alias: PrP33-35C
alias: PrP27-30
alias: P27-30
alias: ASCR
alias: CJD
alias: GSS
alias: PrP
alias: Gerstmann-Strausler-Scheinker Syndrome
alias: Creutzfeldt-Jakob Disease
alias: Fatal Familial Insomnia
alias: Prion Protein (P27-30)
alias: Prion-Related Protein
alias: ALTPRP
alias: KURU
alias: PrPc
title: PRNP
hgnc name: PRNP
URN: urn:edrn:bmdb:biomarker:1553
description: From NCBI Gene: he protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
QA state: New
security: Public
type: Protein
is panel: 0
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:9449
references resource: https://www.ncbi.nlm.nih.gov/gene/5621
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: F7VJQ1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/30
type: Biomarker
alias: CRTL1
alias: HPLN1
alias: Proteoglycan link protein
alias: Cartilage link protein
alias: LP
alias: Hyaluronan and proteoglycan link protein 1 [Precursor]
alias: cartilage linking protein 1
alias: HAPLN1
title: HAPLN1
hgnc name: HAPLN1
URN: urn:edrn:bmdb:biomarker:30
description: This widely expressed protein stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Pass New York University School of Medicine
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/22
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:2380
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: P10915
references resource: https://www.ncbi.nlm.nih.gov/gene/1404
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/538
type: Biomarker
alias: EDNRB
alias: Endothelin Receptor Type B
alias: HSCR2
alias: ETB
alias: HSCR
alias: Endothelin Receptor Non-Selective Type
alias: ET-B
alias: ET-BR
alias: ETRB
alias: ABCDS
alias: WS4A
alias: ETBR
alias: Endothelin B Receptor
title: EDNRB
hgnc name: EDNRB
URN: urn:edrn:bmdb:biomarker:538
description: From Entrez Gene: The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2011)
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/128
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/1910
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P24530

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/393
type: Biomarker
alias: SLC30A6
alias: Q6NXT4
alias: solute carrier family 30 (zinc transporter), member 6
alias: Zinc transporter 6
alias: ZNT6
alias: FLJ31101
alias: Solute carrier family 30 member 6
alias: MGC45055
alias: MST103
alias: MSTP103
alias: OTTHUMP00000158572
alias: OTTHUMP00000201174
alias: OTTHUMP00000201177
alias: OTTHUMP00000201178
title: SLC30A6
hgnc name: SLC30A6
URN: urn:edrn:bmdb:biomarker:393
description: SLC30A6 is a zinc-efflux transporter which has been shown by similarity to be involved in distributing the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment. SLC30A6, a member of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, permits cellular efflux of zinc.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/55676
references resource: Q6NXT4

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/913
type: Biomarker
alias: ENG
alias: CD105
alias: HHT1
alias: CD105 antigen
alias: Osler-Rendu-Weber syndrome 1
alias: END
alias: ORW
alias: ORW1
alias: endoglin
title: ENG
hgnc name: ENG
URN: urn:edrn:bmdb:biomarker:913
description: ENG, or endoglin, is a cell surface adhesion protein involved the regulation of angiogenesis. ENG is a major glycoprotein of the vascular endothelium and is also a component of the transforming growth factor beta receptor complex. ENG binds to the beta1 and beta3 peptides with high affinity. ENG may also be involved in preeclampsia and several types of cancer. There are several isoforms encoded by transcript variants.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/218
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/2022
references resource: P17813

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/385
type: Biomarker
alias: LZTS1
alias: Q9Y250
alias: F37/esophageal cancer-related gene-coding leucine-zipper motif
alias: FEZ1
alias: Fez1
alias: F37
alias: F37/Esophageal cancer-related gene-coding leucine-zipper motif
alias: leucine zipper putative tumor suppressor 1
alias: leucine zipper, putative tumor suppressor 1
title: LZTS1
hgnc name: LZTS1
URN: urn:edrn:bmdb:biomarker:385
description: LZTS1 is a tumor suppressor protein that is widely expressed in normal tissues. It is involved in regulating cell growth and is also thought to interact with the active CDC2-cyclin B1 complex and contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer, and this gene is located on 8p22.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/196
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:13861
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/11178
references resource: Q9Y250

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1126
type: Biomarker
alias: CancerSEEK
title: CancerSEEK
URN: urn:edrn:bmdb:biomarker:1126
description: Detection of genetic mutations associated with pancreatic and ovarian cancer. 2019 FDA break through device. Commercial partner is Thrive Earlier Detection Corp. From https://thrivedetect.com/cancerseek/: CancerSEEK is a blood test (also called a liquid biopsy) designed to detect multiple types of cancer at the earliest stages possible, before noticeable symptoms occur.
QA state: Curated
security: Public
type: Genetic
is panel: 0
access granted to: Allen Duke University
access granted to: Brand University of Pittsburgh
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Hanash The University of Texas MD Anderson Cancer Center
access granted to: National Cancer Institute
access granted to: Schoen University of Pittsburgh
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/259
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/276
references resource: cancerseek
references resource: breakthrough-devices-program

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/930
type: Biomarker
alias: MYCBP
alias: associate of myc-1
alias: Associate of Myc 1
alias: C-Myc-binding protein
alias: AMY1
alias: c-myc binding protein
alias: AMY-1
title: MYCBP
hgnc name: MYCBP
URN: urn:edrn:bmdb:biomarker:930
description: MYCBP, or MYC binding protein, or C-MYC binding protein, binds to the N-terminus of the oncogenic protein MYC, also known as C-MYC, enhancing the ability of MYC to activate E box-dependent transcription. MYCBP is normally found in the cytoplasm, but it moves to the nucleus during the S phase of the cell cycle and associates with MYC.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/26292
references resource: Q99417

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/907
type: Biomarker
alias: DGCR6
alias: protein DGCR6
alias: DiGeorge syndrome critical region 6
alias: DiGeorge syndrome critical region gene 6
alias: DiGeorge syndrome critical region protein 6
title: DGCR6
hgnc name: DGCR6
URN: urn:edrn:bmdb:biomarker:907
description: DGCR6 is located on chromosome 22q11.21. Microdeletions in this region are associated with DiGeorge syndrome, and more widely, the CATCH 22 syndrome. DGCR6, also known as DiGeorge syndrome critical region 6, is thought to be involved in DiGeorge syndrome pathology and in schizophrenia. Another function attributed to this gene is a role in neural crest cell migration into the third and fourth pharyngeal pouches. The DGCR6 protein shares homology with the Drosophila melanogaster gonadal protein, which participates in gonadal and germ cell development, and with the gamma-1 subunit of human laminin.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/8214
references resource: Q14129

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/921
type: Biomarker
alias: HSD17B10
alias: hydroxysteroid (17-beta) dehydrogenase 10
alias: DUPXp11.22
alias: CAMR
alias: short chain type dehydrogenase/reductase XH98G2
alias: AB-binding alcohol dehydrogenase
alias: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
alias: MRX31
alias: mitochondrial ribonuclease P protein 2
alias: Short-chain type dehydrogenase/reductase XH98G2
alias: endoplasmic reticulum-associated amyloid beta-peptide-binding protein
alias: amyloid-beta peptide binding alcohol dehydrogenase
alias: SDR5C1
alias: short chain dehydrogenase/reductase family 5C, member 1
alias: hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxyacyl-Coenzyme A dehydrogenase, type II
alias: Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
alias: Mitochondrial RNase P protein 2
alias: HADH2
alias: Type II HADH
alias: MRX17
alias: 3-hydroxyacyl-CoA dehydrogenase type-2
alias: MRXS10
alias: mitochondrial RNase P subunit 2
alias: mental retardation, X-linked, syndromic 10
alias: 17-beta-HSD 10
alias: ERAB
alias: short chain L-3-hydroxyacyl-CoA dehydrogenase type 2
alias: MRPP2
alias: SCHAD
alias: ABAD
alias: XH98G2
alias: 17-beta-hydroxysteroid dehydrogenase 10
alias: 17b-HSD10
alias: HCD2
alias: MHBD
alias: Mitochondrial ribonuclease P protein 2
alias: 3-hydroxyacyl-CoA dehydrogenase type II
alias: EC 1.1.1.35,EC 1.1.1.178
title: HSD17B10
hgnc name: HSD17B10
URN: urn:edrn:bmdb:biomarker:921
description: HSD17B10, hydroxysteroid (17-beta) dehydrogenase 10, is a member of the short-chain dehydrogenase/reductase superfamily. HSD17B10 functions in mitochondrial tRNA maturation and catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein is thought to play a role in the development of Alzheimer's disease. There are several alternatively spliced transcript variants, of which only two have been fully sequenced.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.ncbi.nlm.nih.gov/gene/3028
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: Q99714

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/915
type: Biomarker
alias: FAS
alias: CD95 antigen
alias: APO-1
alias: FASLG receptor
alias: ALPS1A
alias: tumor necrosis factor receptor superfamily, member 6
alias: tumor necrosis factor receptor superfamily member 6
alias: apoptosis-mediating surface antigen FAS
alias: TNFRSF6
alias: APT1
alias: CD95
alias: Fas AMA
alias: FASTM
alias: Apoptosis-mediating surface antigen FAS
alias: FAS 827dupA
alias: Delta Fas/APO-1/CD95
alias: Apo-1 antigen
alias: apoptosis antigen 1
alias: APO-1 cell surface antigen
alias: Fas (TNF receptor superfamily, member 6)
alias: FAS1
alias: FAS (Ab2)
alias: FAS (Ab1)
title: FAS
hgnc name: FAS
URN: urn:edrn:bmdb:biomarker:915
description: FAS is a member of the TNF-receptor superfamily. The FAS protein is a receptor for TNFSF6/FASLG and has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/355
references resource: P25445

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/904
type: Biomarker
alias: COX7A1
alias: cytochrome c oxidase subunit VIIa heart/muscle isoform
alias: Cytochrome c oxidase subunit VIIa-muscle
alias: COX7AM
alias: Cytochrome c oxidase subunit VIIa-H
alias: cytochrome c oxidase subunit VIIa-heart
alias: cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
alias: cytochrome c oxidase subunit VIIa-H
alias: COX7AH
alias: cytochrome c oxidase subunit VIIa-muscle
alias: Cytochrome c oxidase subunit VIIa-M
alias: cytochrome c oxidase subunit 7A1, mitochondrial
alias: cytochrome c oxidase subunit VIIa-M
alias: COX7A
alias: Cytochrome c oxidase subunit VIIa-heart
title: COX7A1
hgnc name: COX7A1
URN: urn:edrn:bmdb:biomarker:904
description: COX7A1, cytochrome c oxidase subunit VIIa polypeptide 1 (muscle), is one of the polypeptide chains of cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain. This polypeptide is present only in muscle tissues. Other polypeptides of subunit VIIa are present in both muscle and nonmuscle tissues, and are encoded by different genes.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/1346
references resource: P24310

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/387
type: Biomarker
alias: OLFML2B
alias: Q68BL8
alias: olfactomedin-like protein 2B
alias: DKFZP586L151
alias: RP11-227F8.1
alias: olfactomedin-like 2B
alias: photomedin-2
alias: Photomedin-2
title: OLFML2B
hgnc name: OLFML2B
URN: urn:edrn:bmdb:biomarker:387
description: From NCBI Gene: This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/196
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:24558
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/25903
references resource: Q68BL8

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/914
type: Biomarker
alias: EP300
alias: E1A-associated protein p300
alias: P300
alias: p300 HAT
alias: p300
alias: histone acetyltransferase p300
alias: E1A binding protein p300
alias: RSTS2
alias: E1A-binding protein, 300kD
alias: KAT3B
alias: EC 2.3.1.48
title: EP300
hgnc name: EP300
URN: urn:edrn:bmdb:biomarker:914
description: EP300, or E1A binding protein p300, functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. EP300 is important in the processes of cell proliferation and differentiation, and also functions as acetyltransferase for nonhistone targets. EP300 mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/2033
references resource: Q09472

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/29
type: Biomarker
alias: MMP9
alias: 92 kDa type IV collagenase
alias: Gelatinase B
alias: GELB
alias: CLG4B
alias: metalloproteinase-9 [Precursor]
alias: 92kDa gelatinase
alias: matrix metallopeptidase 9
alias: MMP-9
title: MMP9
hgnc name: MMP9
URN: urn:edrn:bmdb:biomarker:29
description: MMP9 is a member of the matrix metalloproteinase (MMP) family. It is a secreted protein that may play an essential role in local proteolysis of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. MMP9 also plays a role in leukocyte migration. Murine studies suggest a role in tumor-associated tissue remodeling
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Instititute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
access granted to: Pass New York University School of Medicine
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/20
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: P14780
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: !/hgnc id/HGNC:7176
references resource: NP 004985.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/366
type: Biomarker
alias: EGFL6
alias: Q8IUX8
alias: MAM and EGF domain containing
alias: EGF-like protein 6
alias: EGF-like-domain, multiple 6
alias: W80
alias: MAEG
alias: EGF repeat-containing protein 6
alias: epidermal growth factor-like protein 6
alias: MAM and EGF domains-containing gene protein
title: EGFL6
hgnc name: EGFL6
URN: urn:edrn:bmdb:biomarker:366
description: From NCBI Gene: This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/196
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/197
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:3235
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/25975
references resource: Q8IUX8

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/189
type: Biomarker
alias: TNFRSF21
alias: tumor necrosis factor receptor superfamily, member 21
alias: DR6
alias: death receptor 6
alias: CD_antigen=CD358
alias: UNQ437/PRO868
title: TNFRSF21
hgnc name: TNFRSF21
URN: urn:edrn:bmdb:biomarker:189
description: From NCBI Gene: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/196
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/27242
references resource: O75509

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/640
type: Biomarker
alias: EHF
alias: ets homologous factor
alias: Epithelium-specific Ets transcription factor 3
alias: ETS homologous factor
alias: ESE-3
alias: ESEJ
alias: ESE3 transcription factor
alias: ESE3
alias: ESE3B
alias: ETS domain-containing transcription factor
alias: epithelium-specific Ets transcription factor 3
alias: hEHF
title: EHF
hgnc name: EHF
URN: urn:edrn:bmdb:biomarker:640
description: From NCBI Gene: This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/26298
references resource: Q9NZC4
references resource: http://www.omim.org/entry/605439

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/566
type: Biomarker
alias: AMFR
alias: E3 ubiquitin-protein ligase AMFR
alias: autocrine motility factor receptor, E3 ubiquitin protein ligase
alias: RNF45
alias: autocrine motility factor receptor
alias: gp78
alias: AMF receptor, isoform 2
alias: Autocrine motility factor receptor, isoform 2
alias: AMF receptor, isoform 1
alias: RING finger protein 45
alias: GP78
alias: EC 6.3.2.-
title: AMFR
hgnc name: AMFR
URN: urn:edrn:bmdb:biomarker:566
description: autocrine motility factor receptor, E3 ubiquitin protein ligase
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/267
references resource: Q9UKV5
references resource: http://www.omim.org/entry/603243

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/641
type: Biomarker
alias: EIF5A
alias: MGC104255
alias: eukaryotic initiation factor 5A
alias: EIF5A1
alias: eIF-5A1
alias: EIF-5A
alias: MGC99547
alias: eIF-5A
alias: eIF5AI
alias: Eukaryotic initiation factor 5A isoform 1
alias: eukaryotic translation initiation factor 5A
alias: eIF-4D
alias: Rev-binding factor
alias: rev-binding factor
alias: eIF-5A-1
alias: eukaryotic translation initiation factor 5A-1
title: EIF5A
hgnc name: EIF5A
URN: urn:edrn:bmdb:biomarker:641
description: From UniProtKB/Swiss-Prot: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Also described as a cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts.
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/1984
references resource: P63241
references resource: http://www.omim.org/entry/600187

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/76
type: Biomarker
alias: eotaxin
alias: CCL11
alias: chemokine (C-C motif) ligand 11
alias: SCYA11
alias: eotaxin-1
alias: MGC22554
alias: small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
alias: small inducible cytokine A11
alias: eosinophil chemotactic protein
alias: C-C motif chemokine 11
title: CCL11
hgnc name: CCL11
URN: urn:edrn:bmdb:biomarker:76
description: From NCBI Gene: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Instititute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: !/hgnc id/HGNC:10610
references resource: Q6I9T4
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 002977.1
references resource: http://www.ncbi.nlm.nih.gov/gene/6356

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/663
type: Biomarker
alias: FMO5
alias: Dimethylaniline oxidase 5
alias: hepatic flavin-containing monooxygenase 5
alias: dimethylaniline monooxygenase [N-oxide-forming] 5
alias: Hepatic flavin-containing monooxygenase 5
alias: FMO 5
alias: flavin containing monooxygenase 5
alias: dimethylaniline oxidase 5
alias: EC 1.14.13.8
title: FMO5
hgnc name: FMO5
URN: urn:edrn:bmdb:biomarker:663
description: From NCBI Gene: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/2330
references resource: P49326
references resource: http://www.omim.org/entry/603957
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1548
type: Biomarker
alias: PGD
alias: Phosphogluconate Dehydrogenase
alias: 6-Phosphogluconate Dehydrogenase, Decarboxylating
alias: 6PGD
alias: PGDH
title: PGD
hgnc name: PGD
URN: urn:edrn:bmdb:biomarker:1548
description: From NCBI Gene: 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
QA state: New
security: Public
type: Protein
is panel: 0
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:8891
references resource: https://www.ncbi.nlm.nih.gov/gene/5226
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: P52209

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1014
type: Biomarker
alias: NLRP1
alias: NALP1
alias: CARD7
alias: DEFCAP
alias: NACHT, Leucine Rich Repeat And PYD (Pyrin Domain) Containing 1
alias: Caspase Recruitment Domain-Containing Protein 7
alias: Death Effector Filament-Forming Ced-4-Like Apoptosis Protein
alias: Nucleotide-Binding Domain And Caspase Recruitment Domain
alias: NAC
alias: SLEV1
alias: VAMAS1
alias: KIAA0926
alias: Leucine Rich Repeat And Pyrin Domain Containing 1
alias: Nucleotide-Binding Oligomerization Domain
alias: CIDED
alias: CLR17.1
alias: DEFCAP-L/S
alias: PP1044
alias: Caspase Recruitment Domain Protein 7
alias: NACHT, Leucine Rich Repeat And PYD Containing 1
alias: NACHT, LRR And PYD Containing Protein 1
alias: NACHT, LRR And PYD Domains-Containing Protein 1
alias: Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 1
title: NLRP1
hgnc name: NLRP1
URN: urn:edrn:bmdb:biomarker:1014
description: From NCBI Gene: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/22861
references resource: Q9C000
references resource: http://omim.org/entry/606636

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1015
type: Biomarker
alias: SERINC2
alias: serine incorporator 2
alias: TDE2L
alias: tumor differentially expressed 2-like
alias: FKSG84
alias: PRO0899
alias: TDE2
title: SERINC2
hgnc name: SERINC2
URN: urn:edrn:bmdb:biomarker:1015
description: From NCBI Gene: Predicted to be involved in several processes, including phosphatidylserine metabolic process; positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; and positive regulation of serine C-palmitoyltransferase activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/347735
references resource: Q96SA4
references resource: http://www.omim.org/entry/614549

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/905
type: Biomarker
alias: CPXCR1
alias: CPX chromosomal region candidate gene 1 protein
alias: cancer/testis antigen 77
alias: CPX chromosome region, candidate 1
alias: Cancer/testis antigen 77
alias: CT77
title: CPXCR1
hgnc name: CPXCR1
URN: urn:edrn:bmdb:biomarker:905
description: CPXCR1 is located in a region on the X chromosome that has been associated with X-linked cleft palate (CPX) disorder. CPXCR1 contains a motif found in several zinc finger proteins. Several alternatively spliced transcripts have been isolated, all encoding the same protein.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/53336
references resource: Q8N123

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/954
type: Biomarker
alias: STAT6
alias: IL-4-STAT
alias: STAT6B
alias: transcription factor IL-4 STAT
alias: D12S1644
alias: STAT6C
alias: STAT, interleukin4-induced
alias: signal transducer and activator of transcription 6
alias: signal transducer and activator of transcription 6, interleukin-4 induced
alias: IL-4 Stat
title: STAT6
hgnc name: STAT6
URN: urn:edrn:bmdb:biomarker:954
description: STAT6 is a member of the STAT family of transcription factors. STAT family members are phosphorylated by the receptor associated kinases in response to cytokines and growth factors and are involved in signal transduction and activation of transcription. There are several transcript variants produced by alternative splicing.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/226
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6778
references resource: P42226

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/234
type: Biomarker
alias: KLK8
alias: kallikrein-related peptidase 8
alias: kallikrein 8 (neuropsin/ovasin)
alias: PRSS19
alias: HNP
alias: neuropsin
alias: ovasin
alias: TADG14
alias: NP
alias: NRPN
alias: Neuropsin
alias: Ovasin
alias: Serine protease 19
alias: Serine protease TADG-14
alias: Tumor-associated differentially expressed gene 14 protein
alias: hK8
title: KLK8
hgnc name: KLK8
URN: urn:edrn:bmdb:biomarker:234
description: KLK8, a member of the kallikrein subgroup of serine proteases, is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Kallikreins have been implicated in carcinogenesis, and some have potential as novel cancer and other disease biomarkers. KLK8 is one of fifteen kallikrein subfamily members located in a cluster on chromosome 19. The four isoforms of KLK8 are a result of alternate splicing of the gene. The isoforms exhibit distinct patterns of expression that suggest roles in brain plasticity and ovarian cancer.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/192
references resource: !/hgnc id/HGNC:6369
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: O60259
references resource: ENSG00000129455
references resource: http://www.ncbi.nlm.nih.gov/gene/11202

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/368
type: Biomarker
alias: EPSTI1
alias: Q96J88
alias: epithelial stromal interaction 1 (breast)
alias: epithelial stromal interaction protein 1
alias: BRESI1
alias: epithelial-stromal interaction protein 1
alias: MGC29634
title: EPSTI1
hgnc name: EPSTI1
URN: urn:edrn:bmdb:biomarker:368
description: EPSTI1 is highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. There are three isoforms of this protein, produced by alternative splicing.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/214
references resource: http://www.genenames.org/cgi-bin/search
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/94240
references resource: Q96J88

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/684
type: Biomarker
alias: HIST1H2BF
alias: Histone H2B.G
alias: Histone H2B.1 A
alias: Histone Cluster 1, H2bf
alias: Histone 1, H2bf
alias: Histone H2B Type 1-C/E/F/G/I
alias: H2B Histone Family, Member G
alias: Histone Cluster 1 H2B Family Member F
alias: H2BFG
alias: H2B/G
alias: H2BC7
alias: H2B Clustered Histone 7
alias: Histone H2B.A
alias: Histone H2B.H
alias: Histone H2B.K
alias: Histone H2B.L
alias: HIST1H2BC
alias: HIST1H2BE
alias: HIST1H2BG
alias: HIST1H2BI
alias: H2BC10
alias: H2BC4
alias: H2BC6
alias: H2BC8
alias: H2BFL
alias: H2BFH
alias: H2BFA
alias: H2BFK
alias: H2B/A
alias: H2B/H
alias: H2B/K
alias: H2B/L
title: H2BC7
hgnc name: H2BC7
URN: urn:edrn:bmdb:biomarker:684
description: This gene was formerly known as HIST1H2BF. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. The protein has antibacterial and antifungal antimicrobial activity. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: !/hgnc id/HGNC:4752
references resource: http://www.ncbi.nlm.nih.gov/gene/8343
references resource: P62807
references resource: http://omim.org/entry/608268
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1010
type: Biomarker
alias: Histone H2B.K
alias: Histone H2B.G
alias: Histone H2B.A
alias: Histone H2B.H
alias: Histone Cluster 1, H2be
alias: Histone H2B.1 A
alias: Histone H2B Type 1-C/E/F/G/I
alias: H2B Histone Family, Member H
alias: Histone Cluster 1 H2B Family Member E
alias: H2BFH
alias: H2B.H
alias: HIST1H2BE
alias: H2B/H
alias: H2B Clustered Histone 6
alias: Histone 1, H2be
alias: Histone H2B.L
alias: DJ221C16.8
alias: HIST1H2BC
alias: HIST1H2BF
alias: HIST1H2BG
alias: HIST1H2BI
alias: H2BC10
alias: H2BC4
alias: H2BC7
alias: H2BC8
alias: H2BC6
alias: H2BFL
alias: H2BFG
alias: H2BFK
alias: H2BFA
alias: H2B/A
alias: H2B/G
alias: H2B/K
alias: H2B/L
title: H2BC6
hgnc name: H2BC6
URN: urn:edrn:bmdb:biomarker:1010
description: This gene was formerly known as HIST1H2BE. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/8344
references resource: P62807
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: https://www.omim.org/entry/602805

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/897
type: Biomarker
alias: ATP6V1G1
alias: V-ATPase 13 kDa subunit 1
alias: Vacuolar proton pump subunit G 1
alias: ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G isoform 1
alias: vacuolar proton pump subunit M16
alias: vacuolar proton pump subunit G 1
alias: vacuolar H(+)-ATPase subunit G 1
alias: vacuolar ATP synthase subunit M16
alias: ATP6G1
alias: Vma10
alias: ATPase, H+ transporting, lysosomal (vacuolar proton pump), member J
alias: DKFZp547P234
alias: ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
alias: ATP6GL
alias: V-type proton ATPase subunit G 1
alias: V-ATPase subunit G 1
alias: ATP6J
alias: Vacuolar proton pump subunit M16
alias: ATP6G
title: ATP6V1G1
hgnc name: ATP6V1G1
URN: urn:edrn:bmdb:biomarker:897
description: ATP6V1G1 is a subunit of vacuolar ATPase (V-ATPase), a multisubunit enzyme. V-ATPase is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. This acidification process is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes, endosomes, the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/9550
references resource: O75348

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/69
type: Biomarker
alias: ITIH4
alias: IHRP
alias: H4P
alias: ITIHL1
alias: Inter-alpha-trypsin inhibitor heavy chain H4
alias: Inter-alpha-inhibitor heavy chain 4
alias: ITI heavy chain H4
alias: ITI-HC4
alias: Inter-alpha-trypsin inhibitor family heavy chain-related protein
alias: Plasma kallikrein sensitive glycoprotein 120
alias: PK-120
alias: Gp120
alias: PK120
alias: PRO1851
title: ITIH4
hgnc name: ITIH4
URN: urn:edrn:bmdb:biomarker:69
description: The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain - bikunin, encoded by AMBP - and five homologous heavy chains (encoded by ITIH1, ITIH2, ITIH3, ITIH4, and ITIH5), contributing to extracellular matrix stability by covalent linkage to hyaluronan. ITIH4 is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of the ITIH4 gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Bast MD Anderson
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:6169
references resource: Q14624
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 002209.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/898
type: Biomarker
alias: BANK1
alias: B-cell scaffold protein with ankyrin repeats 1
alias: BANK
alias: FLJ20706
alias: B-cell scaffold protein with ankyrin repeats
title: BANK1
hgnc name: BANK1
URN: urn:edrn:bmdb:biomarker:898
description: BANK1 is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. It also promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. There are several transcript variants resulting from alternative splicing.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/55024
references resource: Q8NDB2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/68
type: Biomarker
alias: HEPC
alias: HAMP
alias: LEAP-1
alias: HFE2B
alias: LEAP1
alias: hepcidin antimicrobial peptide
alias: PLTR
alias: HEPCIDIN
alias: Liver-expressed antimicrobial peptide 1
alias: Putative liver tumor regressor
alias: hepcidin-25
alias: hepcidin
title: HAMP
hgnc name: HAMP
URN: urn:edrn:bmdb:biomarker:68
description: HEPC, also known as HAMP, is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Bast MD Anderson
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/173
references resource: !/hgnc id/HGNC:15598
references resource: P81172
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 066998.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/107
type: Biomarker
alias: Vimentin, methylated
alias: VIM
alias: Aberrant Vimentin DNA Methylation in Stool
alias: Vimentin methylation in stool
alias: Vimentin methylation (Colosure)
title: Vimentin methylation (Colosure)
hgnc name: VIM
URN: urn:edrn:bmdb:biomarker:107
description: The VIM gene encodes a member of the intermediate filament family. VIM proteins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. These intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton.
QA state: Curated
security: Public
type: Epigenetic
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Markowitz Case Western Reserve University
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/177
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/178
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/284
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/285
references resource: http://www.ncbi.nlm.nih.gov/gene/7431
references resource: !/hgnc id/HGNC:12692
references resource: P08670
references resource: page2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/231
type: Biomarker
alias: TSH
alias: TSHB
alias: thyroid stimulating hormone, beta
alias: TSH-BETA
alias: TSH-B
alias: TSH-beta
alias: Thyrotropin beta chain
alias: INN=Thyrotropin alfa
alias: Thyroid-stimulating hormone subunit beta
alias: thyrotropin beta subunit
alias: thyrotropin subunit beta
alias: CHNG4
alias: Thyrotropin alfa
title: TSHB
hgnc name: TSHB
URN: urn:edrn:bmdb:biomarker:231
description: TSH, a secreted protein belonging to the glycoprotein hormones subunit beta family, is essential for the control of thyroid structure and metabolism. The four human glycoprotein hormones - chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH)- are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Congenital hypothyroidism is caused by mutation in the TSH gene.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:12372
references resource: P01222
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000540.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/383
type: Biomarker
alias: KIBRA
alias: Q8IX03
alias: HBeAg-binding protein 3
alias: protein KIBRA
alias: kidney and brain protein
alias: WW, C2 and coiled-coil domain containing 1
alias: HBEBP36
alias: WW domain-containing protein 1
alias: protein WWC1
alias: KIAA0869
alias: Kidney and brain protein
alias: WW and C2 domain containing 1
alias: WWC1
alias: HBEBP3
title: WWC1
hgnc name: WWC1
URN: urn:edrn:bmdb:biomarker:383
description: From NCBI Gene: The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:29435
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/23286
references resource: Q8IX03

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/397
type: Biomarker
alias: TSG6
alias: P98066
alias: TNFAIP6
alias: TSG-6
alias: Tumor necrosis factor-inducible gene 6 protein
alias: tumor necrosis factor, alpha-induced protein 6
alias: Hyaluronate-binding protein
alias: TNF alpha-induced protein 6
alias: TNF-stimulated gene 6 protein
alias: tumor necrosis factor-inducible gene 6 protein
alias: tumor necrosis factor-stimulated gene-6 protein
title: TNFAIP6
hgnc name: TNFAIP6
URN: urn:edrn:bmdb:biomarker:397
description: From NCBI Gene: The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/7130
references resource: P98066

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/899
type: Biomarker
alias: BRCA1
alias: PSCP
alias: BRCA1/BRCA2-containing complex, subunit 1
alias: RNF53
alias: PNCA4
alias: IRIS
alias: breast and ovarian cancer sususceptibility protein 1
alias: protein phosphatase 1, regulatory subunit 53
alias: BRCAI
alias: breast cancer 1, early onset
alias: breast cancer type 1 susceptibility protein
alias: BRCC1
alias: PPP1R53
alias: breast and ovarian cancer susceptibility protein 1
alias: RING finger protein 53
alias: BROVCA1
alias: EC 6.3.2.-
title: BRCA1
hgnc name: BRCA1
URN: urn:edrn:bmdb:biomarker:899
description: BRCA1 is a nuclear phosphoprotein that functions as a tumor suppressor. BRCA1 combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). BRCA1 associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/672
references resource: Q14596

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1127
type: Biomarker
alias: Overa
title: Overa
URN: urn:edrn:bmdb:biomarker:1127
description: From Vermillion website: Overa, a second-generation Multivariate Index Assay (MIA2G) is an FDA-cleared blood test for women with a pelvic mass who are planned for surgery. Overa (MIA2G) maintains the high level of ovarian cancer detection, across rare subtypes and including early stage cancers, afforded by OVA1 (MIA). However, Overa (MIA2G) incorporates different markers and a refined algorithm in order to improve the balance between ovarian cancer detection and healthcare efficiency. Overa (MIA2G) represents a significant improvement in positive predictive value, overall accuracy and a reduction in false positives and unnecessary referrals. https://vermillion.com/our-products/ova1-ova1plus/
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/937
type: Biomarker
alias: POLR2L
alias: polymerase (RNA) II (DNA directed) polypeptide L (7.6kD)
alias: RPB10 homolog
alias: DNA-directed RNA polymerases I, II, and III subunit RPABC5
alias: DNA-directed RNA polymerase III subunit L
alias: hRPB7.6
alias: RNA polymerases I, II, and III subunit ABC5
alias: RPB10
alias: hsRPB10b
alias: RNA polymerase II 7.6 kDa subunit
alias: RPABC5
alias: RPB10beta
alias: polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
alias: RPB7.6
alias: RBP10
title: POLR2L
hgnc name: POLR2L
URN: urn:edrn:bmdb:biomarker:937
description: POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/5441
references resource: P62875

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/225
type: Biomarker
alias: Chitinase
alias: CHI3L1
alias: chitinase 3-like 1 (cartilage glycoprotein-39)
alias: GP39
alias: ASRT7
alias: GP-39
alias: YKL40
alias: CGP-39
alias: YKL-40
alias: YYL-40
alias: HC-gp39
alias: HCGP-3P
alias: hCGP-39
alias: FLJ38139
alias: DKFZp686N19119
alias: 39 kDa synovial protein
alias: Cartilage glycoprotein 39
alias: Chitinase-3-like protein 1
title: CHI3L1
hgnc name: CHI3L1
URN: urn:edrn:bmdb:biomarker:225
description: CHI3L1, also known as chitinase, a secreted protein, is a carbohydrate-binding lectin with a preference for chitin. It may play a role in defense against pathogens, or in tissue remodeling. It may also play an important role in the capacity of cells to respond to and cope with changes in their environment. CHI3L1 is present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. It is undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.
QA state: Curated
security: Public
type: Protein
is panel: 0
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:1932
references resource: P36222
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 001267.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/958
type: Biomarker
alias: TRAF4
alias: MLN 62
alias: Metastatic lymph node gene 62 protein
alias: tumor necrosis receptor-associated factor 4A
alias: CART1
alias: TNF receptor-associated factor 4
alias: malignant 62
alias: RNF83
alias: Cysteine-rich domain associated with RING and Traf domains protein 1
alias: RING finger protein 83
alias: cysteine-rich domain associated with ring and TRAF domain
alias: metastatic lymph node gene 62 protein
alias: cysteine-rich domain associated with RING and Traf domains protein 1
alias: MLN62
title: TRAF4
hgnc name: TRAF4
URN: urn:edrn:bmdb:biomarker:958
description: TRAF4 is a member of the TNF receptor associated factor (TRAF) family. Members of the TRAF family are the major signal transducers for the TNF receptor (TNFR) superfamily and the interleukin-1 receptor/Toll-like receptor superfamily. TRAF4 is involved in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/229
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/230
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/9618
references resource: Q9BUZ4

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/603
type: Biomarker
alias: CDKN1A
alias: DNA synthesis inhibitor
alias: cyclin-dependent kinase inhibitor 1
alias: MDA-6
alias: CAP20
alias: cyclin-dependent kinase inhibitor 1A (p21, Cip1)
alias: p21
alias: WAF1
alias: melanoma differentiation associated protein 6
alias: CIP1
alias: CDKN1
alias: P21
alias: p21CIP1
alias: SDI1
alias: CDK-interaction protein 1
alias: p21Cip1/Waf1
alias: wild-type p53-activated fragment 1
alias: PIC1
alias: CDK-interacting protein 1
alias: MDA6
alias: Melanoma differentiation-associated protein 6
title: CDKN1A
hgnc name: CDKN1A
URN: urn:edrn:bmdb:biomarker:603
description: From NCBI Gene: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/1026
references resource: P38936
references resource: http://omim.org/entry/116899

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/509
type: Biomarker
alias: Bianchi 34-marker miRNA Signature for Lung Cancer
alias: Bianchi 34 marker miRNA Signature for Lung Cancer
title: Bianchi 34 marker miRNA Signature for Lung Cancer
URN: urn:edrn:bmdb:biomarker:509
description: This signature was developed based on the detection of 34 microRNAs (miRNAs) from serum that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. The signature could assign disease probability accurately either in asymptomatic or symptomatic patients, is able to distinguish between benign and malignant lesions, and to capture the onset of the malignant disease in individual patients over time.
QA state: Curated
security: Public
type: Proteomic
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/122

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/77
type: Biomarker
alias: MMP3
alias: matrix metallopeptidase 3 (stromelysin 1, progelatinase)
alias: STMY1
alias: STMY
alias: Stromelysin-1
alias: SL-1
alias: Matrix metalloproteinase-3
alias: MMP-3
alias: Transin-1
alias: STR1
alias: CHDS6
alias: MGC126102
alias: MGC126103
alias: MGC126104
alias: proteoglycanase
title: MMP3
hgnc name: MMP3
URN: urn:edrn:bmdb:biomarker:77
description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP3 degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Instititute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: !/hgnc id/HGNC:7173
references resource: P08254
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 002413.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/392
type: Biomarker
alias: SEC23B
alias: Q15437
alias: HEMPAS
alias: CDAN2
alias: CDA-II
alias: CDAII
alias: SEC23-related protein B
alias: Sec23 homolog B (S. cerevisiae)
alias: congenital dyserythropoietic anemia, type II
alias: Sec23 (S. cerevisiae) homolog B
alias: protein transport protein Sec23B
alias: SEC23-like protein B
alias: transport protein SEC23B
title: SEC23B
hgnc name: SEC23B
URN: urn:edrn:bmdb:biomarker:392
description: SEC23B is a member of the SEC23B/SEC24B family. SEC23B is a component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. By similarity, it has been shown that COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/index.php
references resource: http://www.ncbi.nlm.nih.gov/gene/10483
references resource: Q15437

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/537
type: Biomarker
alias: NID2
alias: nidogen 2 (osteonidogen)
alias: NID-2
alias: nidogen-2
alias: osteonidogen
alias: Osteonidogen
title: NID2
hgnc name: NID2
URN: urn:edrn:bmdb:biomarker:537
description: From NCBI Gene: This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.[provided by RefSeq, Jun 2010]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/128
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/145
references resource: !/hgnc id/HGNC:13389
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene
references resource: Q14112

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/371
type: Biomarker
alias: FLJ13910
alias: Q9H871
alias: RMND5A
alias: p44CTLH
alias: CTLH
alias: required for meiotic nuclear division 5 homolog A (S. cerevisiae)
alias: C-terminal to LisH motif, 44 kDa
alias: protein RMD5 homolog A
alias: RMD5
title: RMND5A
hgnc name: RMND5A
URN: urn:edrn:bmdb:biomarker:371
description: From NCBI Gene: Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein polyubiquitination. Located in cytoplasm and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/
references resource: Q9H871

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/373
type: Biomarker
alias: FLJ46072
alias: Q6ZRV2
alias: FAM83H
alias: FAM83H variant 1
alias: AI3
alias: protein FAM83H
alias: family with sequence similarity 83, member H
title: FAM83H
hgnc name: FAM83H
URN: urn:edrn:bmdb:biomarker:373
description: FAM83H is a member of the FAM83 family and plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a cause of amelogenesis imperfecta type 3 (AI3). Lack of a recognizable signal peptide indicates that the protein functions within the cell. It is expressed in the tooth follicle.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/
references resource: Q6ZRV2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/381
type: Biomarker
alias: HOXA9
alias: P31269
alias: homeo box A9
alias: homeodomain protein HOXA9
alias: Homeobox protein Hox-1G
alias: homeobox protein Hox-A9
alias: HOX1G
alias: HOX1
alias: homeobox A9
alias: HOX1.7
alias: ABD-B
alias: homeobox protein Hox-1G
title: HOXA9
hgnc name: HOXA9
URN: urn:edrn:bmdb:biomarker:381
description: From NCBI Gene: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/128
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:5109
references resource: http://www.genecards.org/index.php
references resource: http://www.ncbi.nlm.nih.gov/gene/3205
references resource: P31269

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/28
type: Biomarker
alias: SMRP
alias: MSLN
alias: Soluble Mesothelin Related Peptide
title: SMRP
hgnc name: MSLN
URN: urn:edrn:bmdb:biomarker:28
description: Soluble mesothelin-related protein (SMRP) is related to the mesothelin family of molecules. It is overexpressed in ovarian cancer, malignant pleural mesothelioma (MPM), and certain other cancers. One hypothesis for the origin of SMRP is that this mesothelin-like molecule was released from tumor cells into culture supernatants, sera, and malignant effusions from certain tumors. Another hypothesis is that SMRP is actually a proteolytically cleaved fragment of membrane-bound mesothelin. Currently SMRP is considered to be an isoform of mesothelin (MSLN). UniprotKB/SwissProt lists isoform 3 of human mesothelin (identifier Q13421-2) as SMRP.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Pass New York University School of Medicine
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/7
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/42
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/43
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/68
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/146
references resource: !/hgnc id/HGNC:7371
references resource: http://www.ncbi.nlm.nih.gov/gene/10232
references resource: Q13421
references resource: http://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/927
type: Biomarker
alias: MAGEA6
alias: MAGE3B
alias: MAGE3B antigen
alias: CT1.6
alias: melanoma-associated antigen 6
alias: cancer/testis antigen 1.6
alias: MAGE6
alias: MAGE-3b
alias: MAGE-6 antigen
alias: Cancer/testis antigen 1.6
alias: melanoma antigen family A, 6
alias: cancer/testis antigen family 1, member 6
title: MAGEA6
hgnc name: MAGEA6
URN: urn:edrn:bmdb:biomarker:927
description: The members of the MAGEA protein family display 50-80% sequence identity among their members. MAGEA proteins are thought to play a role in tumor transformation or aspects of tumor progression. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. Alternative splicing results in multiple transcript variants.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/4105
references resource: P43360

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/190
type: Biomarker
alias: CSPG2
alias: VCAN
alias: chondroitin sulfate proteoglycan 2
alias: PG-M
alias: versican proteoglycan
alias: Chondroitin sulfate proteoglycan core protein 2
alias: Glial hyaluronate-binding protein
alias: GHAP
alias: Large fibroblast proteoglycan
alias: versican
alias: ERVR
alias: WGN
alias: WGN1
alias: versican core protein
title: VCAN
hgnc name: VCAN
URN: urn:edrn:bmdb:biomarker:190
description: From NCBI Gene: This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
access granted to: Zhang Johns Hopkins University School of Medicine
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/1462
references resource: P13611

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/78
type: Biomarker
alias: EGFR
alias: epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)
alias: ERBB
alias: ERBB1
alias: Epidermal growth factor receptor
alias: Receptor tyrosine-protein kinase erbB-1
alias: c-erbB-1
alias: HER1
alias: mENA
alias: PIG61
alias: Proto-oncogene c-ErbB-1
alias: avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
alias: cell growth inhibiting protein 40
alias: cell proliferation-inducing protein 61
title: EGFR
hgnc name: EGFR
URN: urn:edrn:bmdb:biomarker:78
description: From NCBI Gene: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
QA state: Curated
security: Public
type: Genomic
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Instititute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/137
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: !/hgnc id/HGNC:3236
references resource: P04412
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 005219.2
references resource: http://www.ncbi.nlm.nih.gov/gene/1956

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/41
type: Biomarker
alias: DJ-1
alias: PARK7
alias: Protein DJ-1
alias: Oncogene DJ-1
alias: Parkinson disease protein 7
alias: DJ1
alias: Parkinson disease (autosomal recessive, early onset) 7
title: PARK7
hgnc name: PARK7
URN: urn:edrn:bmdb:biomarker:41
description: DJ-1, also known as PARK-7, belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. DJ-1 is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart and is detected at slightly lower levels in placenta and brain.
QA state: Accepted
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Hanash Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/27
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/44
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/73
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/74
references resource: Q99497
references resource: !/hgnc id/HGNC:16369
references resource: http://www.genome.jp/dbget-bin/www_bget
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/62
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/41/998

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/902
type: Biomarker
alias: CCND1
alias: G1/S-specific cyclin-D1
alias: B-cell lymphoma 1 protein
alias: PRAD1
alias: PRAD1 oncogene
alias: B-cell CLL/lymphoma 1
alias: cyclin D1
alias: U21B31
alias: BCL1
alias: BCL-1 oncogene
alias: D11S287E
alias: BCL-1
alias: cyclin D1 (PRAD1: parathyroid adenomatosis 1)
title: CCND1
hgnc name: CCND1
URN: urn:edrn:bmdb:biomarker:902
description: CCND1 is a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition.
QA state: Curated
phase: 2
security: Public
type: Glycomic
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/56477
references resource: Q9NRJ3

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/912
type: Biomarker
alias: ELF2
alias: new Ets-related factor
alias: New ETS-related factor
alias: E74-like factor 2
alias: NERF-2
alias: NERF-1a,b
alias: ets family transcription factor ELF2C
alias: E74-like factor 2 (ets domain transcription factor)
alias: NERF
alias: NERF-1A
alias: NERF-1B
alias: EU32
alias: ETS-related transcription factor Elf-2
title: ELF2
hgnc name: ELF2
URN: urn:edrn:bmdb:biomarker:912
description: ELF2 is a nuclear protein that is conserved across several species. Multiple isoforms have been identified. Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter, while isoform 2 is thought to function in repression of RUNX1-mediated transactivation.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/1998
references resource: Q15723

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/920
type: Biomarker
alias: HEXIM1
alias: hexamethylene bisacetamide-inducible protein
alias: menage a quatre protein 1
alias: MAQ1
alias: cardiac lineage protein 1
alias: Cardiac lineage protein 1
alias: protein HEXIM1
alias: CLP-1
alias: Estrogen down-regulated gene 1 protein
alias: Hexamethylene bis-acetamide-inducible protein 1
alias: Menage a quatre protein 1
alias: menage a quatre 1
alias: hexamethylene bis-acetamide inducible 1
alias: hexamethylene-bis-acetamide-inducible transcript 1
alias: HMBA-inducible
alias: HIS1
alias: hexamethylene bis-acetamide-inducible protein 1
alias: CLP1
alias: EDG1
alias: estrogen down-regulated gene 1 protein
alias: hexamthylene bis-acetamide inducible 1
title: HEXIM1
hgnc name: HEXIM1
URN: urn:edrn:bmdb:biomarker:920
description: HEXIM1 is an intronless transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. HEXIM1 expression is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/10614
references resource: O94992

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/79
type: Biomarker
alias: prolactin
alias: PRL
title: PRL
hgnc name: PRL
URN: urn:edrn:bmdb:biomarker:79
description: There is increasing evidence that prolactin (PRL), a hormone/cytokine, plays a role in breast, prostate, and colorectal cancers via local production or accumulation. Elevated levels of serum PRL in ovarian and endometrial cancers have been reported, indicating a potential role for PRL in endometrial and ovarian carcinogenesis.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Marks Duke University Medical Center
access granted to: Mor Yale University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/254
references resource: !/hgnc id/HGNC:9445
references resource: P01236
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000939.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/82
type: Biomarker
alias: IGF2
alias: FLJ44734
alias: C11orf43
alias: chromosome 11 open reading frame 43
alias: insulin-like growth factor 2 (somatomedin A)
alias: INSIGF
alias: pp9974
alias: FLJ22066
alias: Insulin-like growth factor II
alias: IGF-II
alias: Somatomedin-A
alias: PP1446
title: IGF2
hgnc name: IGF2
URN: urn:edrn:bmdb:biomarker:82
description: IGF2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. The IGF2 gene is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Alternatively spliced transcript variants, encoding either the same or different isoform, have been found for this gene. IGF2 is influenced by placental lactogen and may play a role in fetal development.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Mor Yale University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/254
references resource: !/hgnc id/HGNC:5466
references resource: P35858
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000603.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/127
type: Biomarker
alias: EFEMP1
alias: EGF containing fibulin-like extracellular matrix protein 1
alias: DHRD
alias: FBNL
alias: S1-5
alias: FBLN3
alias: MTLV
alias: fibulin 3
alias: Extracellular protein S1-5
alias: Fibrillin-like protein
alias: Fibulin-3
title: EFEMP1
hgnc name: EFEMP1
URN: urn:edrn:bmdb:biomarker:127
description: From NCBI Gene: This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Diamandis Mount Sinai Hospital
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/203
references resource: !/hgnc id/HGNC:3218
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/2202
references resource: Q12805

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/933
type: Biomarker
alias: NOS1
alias: nitric oxide synthase 1 (neuronal)
alias: NC-NOS
alias: N-NOS
alias: Neuronal NOS
alias: NOS type I
alias: peptidyl-cysteine S-nitrosylase NOS1
alias: neuronal NOS
alias: IHPS1
alias: Peptidyl-cysteine S-nitrosylase NOS1
alias: bNOS
alias: nNOS
alias: nitric oxide synthase, brain
alias: constitutive NOS
alias: NOS
alias: Constitutive NOS
alias: EC 1.14.13.39
title: NOS1
hgnc name: NOS1
URN: urn:edrn:bmdb:biomarker:933
description: NOS1, or nitric oxide synthase 1 (neuronal), along with inducible nitric oxide synthase (NOS2) and endothelial nitric oxide synthase (NOS3), catalyze the generation of nitric oxide and L-citrulline from L-arginine and molecular oxygen. Nitric oxide is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter. NOS1 also displays antimicrobial and antitumoral activities.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/4842
references resource: P29475

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/896
type: Biomarker
alias: ARHGEF16
alias: NBR
alias: Rho guanine exchange factor (GEF) 16
alias: GEF16
alias: Ephexin-4
alias: EPHEXIN4
alias: ephexin-4
alias: Rho guanine nucleotide exchange factor (GEF) 16
alias: rho guanine nucleotide exchange factor 16
title: ARHGEF16
hgnc name: ARHGEF16
URN: urn:edrn:bmdb:biomarker:896
description: ARHGEF16 is a guanine nucleotide exchange factor. Guanine nucleotide exchange factors regulate the activation of Rho-like GTPases. Guanidine exchange factors promote the GTP activation of Rho GTPase's by catalyzing the exchange of GDP for GTP.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/217
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/27237
references resource: Q5VV41

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/553
type: Biomarker
alias: Showe 29-gene signature for lung cancer
title: Showe 29-gene signature for lung cancer
URN: urn:edrn:bmdb:biomarker:553
description: A 29-gene peripheral blood gene expression signature that separates patients with non-small cell lung cancer (NSCLC) tumors and patient controls with 86% accuracy (91% sensitivity, 80% specificity). Subjects were primarily smokers and former smokers. The 29 genes, minus one that did not match a gene symbol in the naming database: RSF1, DYRK2, YY1, C19orf12, THEM2, TRIO, MYADM, BAIAP2, ROGDI, DNAJB14, BRE, TMEM41A, C9orf64, FAM110A, PCNXL2, REST, C19orf62, C13orf27, ASCC3, SLC1A5, PTPLAD1, MRE11A, GTPBP10, SERPINI2, CREB1, CCDC53, USP48, ZSCAN2
QA state: Curated
security: Public
type: Gene
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/155

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/550
type: Biomarker
alias: Chen 10-marker miRNA signature for non-small cell lung cancer
alias: Chen 10 marker miRNA signature for non-small cell lung cancer
title: Chen 10 marker miRNA signature for non-small cell lung cancer
URN: urn:edrn:bmdb:biomarker:550
description: A panel of 10 serum miRNAs has been identified that were found to have significantly different expression levels in non-small cell lung cancer (NSCLC) serum samples compared with the control serum samples. This panel of miRNAs was able to distinguish NSCLC cases from controls with high sensitivity and specificity. The ten miRNAs are: miR-20a, miR-24, miR-25, miR-145, miR-152, miR-199a-5p, miR-221, miR-222, miR-223, miR-320.
QA state: Curated
security: Public
type: Genomic
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/150

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/66
type: Biomarker
alias: IGFBP2
alias: BP2
alias: IBP2
alias: Insulin-like growth factor-binding protein 2
alias: IGF-binding protein 2
alias: IGFBP-2
alias: IBP-2
alias: IGF-BP53
title: IGFBP2
hgnc name: IGFBP2
URN: urn:edrn:bmdb:biomarker:66
description: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Insulin-like growth factor binding protein 2 (IGFBP2) is overexpressed in ovarian malignant tissues and in the serum and cystic fluid of ovarian cancer patients, suggesting an important role of IGFBP2 in the biology of ovarian cancer.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: McIntosh Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/83
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:5471
references resource: P18065
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000588.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/810
type: Biomarker
alias: SEL1L3
alias: KIAA0746
alias: protein sel-1 homolog 3
alias: Sel-1L3
alias: sel-1 suppressor of lin-12-like 3 (C. elegans)
alias: suppressor of lin-12-like protein 3
alias: Suppressor of lin-12-like protein 3
title: SEL1L3
hgnc name: SEL1L3
URN: urn:edrn:bmdb:biomarker:810
description: From NCBI Gene: Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2021]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/23231
references resource: Q68CR1
references resource: !/hgnc id/HGNC:29108

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1260
type: Biomarker
alias: Assay-MagPix instrument using the magnetic spectral beads
title: Assay-MagPix instrument using the magnetic spectral beads
URN: urn:edrn:bmdb:biomarker:1260
QA state: New
security: Public
type: Proteomic
is panel: 0

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/918
type: Biomarker
alias: GNB4
alias: Transducin beta chain 4
alias: G protein beta-4 subunit
alias: guanine nucleotide binding protein beta subunit 4
alias: guanine nucleotide binding protein (G protein), beta polypeptide 4
alias: transducin beta chain 4
alias: guanine nucleotide-binding protein subunit beta-4
title: GNB4
hgnc name: GNB4
URN: urn:edrn:bmdb:biomarker:918
description: GNB4 is the beta subunit of a heterotrimeric guanine nucleotide-binding protein (G protein). These proteins also have alpha and gamma subunits. GNB4 and other beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Each type of subunit is encoded by families of related genes.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/59345
references resource: Q9HAV0

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/941
type: Biomarker
alias: PTPRC
alias: CD45
alias: LCA
alias: B220
alias: T200
alias: LY5
alias: T200 leukocyte common antigen
alias: T200 glycoprotein
alias: Leukocyte common antigen
alias: receptor-type tyrosine-protein phosphatase C
alias: L-CA
alias: GP180
alias: protein tyrosine phosphatase, receptor type, C
alias: protein tyrosine phosphatase, receptor type, c polypeptide
alias: CD45R
alias: CD45 antigen
alias: EC 3.1.3.48
title: PTPRC
hgnc name: PTPRC
URN: urn:edrn:bmdb:biomarker:941
description: PTPRC is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. PTPRC is required for T-cell activation through the antigen receptor. PTPRC contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and is classified as a receptor type PTP.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/5788
references resource: P08575

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1590
type: Biomarker
alias: Mercola 15-gene classifier panel for prostate cancer
title: Mercola 15-gene classifier panel for prostate cancer
URN: urn:edrn:bmdb:biomarker:1590
description: From PMID 22870216: A 15-gene classifier. The overall accuracy was 87% when the classifier was tested on 47 independent test samples. Pathway analysis and Gene Ontology studies indicated these 15 genes are significantly enriched for genes that are involved in apoptosis-related processes. These studies supported the possibility that stroma is a practical basis of risk assessment.
QA state: Curated
security: Public
type: Gene
is panel: 1
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/911
type: Biomarker
alias: EFNA5
alias: AF1
alias: EFL5
alias: AL-1
alias: ephrin-A5
alias: EPLG7
alias: LERK-7
alias: eph-related receptor tyrosine kinase ligand 7
alias: EPH-related receptor tyrosine kinase ligand 7
alias: GLC1M
alias: LERK7
alias: RAGS
title: EFNA5
hgnc name: EFNA5
URN: urn:edrn:bmdb:biomarker:911
description: EFNA5 is a cell surface-bound member of the ephrin gene family. Ephrins are proteins that function as ligands for the ephrin receptors (Eph receptors). Eph receptors are a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/1946
references resource: P52803

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/541
type: Biomarker
alias: KIF1A
alias: Kinesin Family Member 1A
alias: ATSV
alias: C2orf20
alias: SPG30
alias: UNC104
alias: Axonal Transporter Of Synaptic Vesicles
alias: Microtubule-Based Motor KIF1A
alias: Unc-104- And KIF1A-Related Protein
alias: Axonal Transport Of Synaptic Vesicles
alias: Chromosome 2 Open Reading Frame 20
alias: Spastic Paraplegia 30 (Autosomal Recessive)
alias: HSN2C
alias: MRD9
alias: Kinesin, Heavy Chain, Member 1A, Homolog Of Mouse
alias: Kinesin-Like Protein KIF1A
alias: Tmp_locus_27
alias: HUnc-104
title: KIF1A
hgnc name: KIF1A
URN: urn:edrn:bmdb:biomarker:541
description: From NCBI Entrez Gene: The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
QA state: Curated
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/128
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/547
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q12756

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/549
type: Biomarker
alias: Spira 80-marker panel plus clinical factors
alias: 80-gene panel
alias: Spira 80 marker panel plus clinical factors
title: Spira 80 marker panel plus clinical factors
URN: urn:edrn:bmdb:biomarker:549
description: This clinicogenomic model incorporates the gene expression pattern of histologcially normal large airway epithelial cells collected at time of bronchoscopy (see 'Spira 80-marker panel for lung cancer') with clinical parameters about lung cancer risk.
QA state: Curated
security: Public
type: Gene
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/148
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/149

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/926
type: Biomarker
alias: LCP2
alias: 76 kDa tyrosine phosphoprotein
alias: SH2 domain-containing leukocyte protein of 76kD
alias: SLP-76 tyrosine phosphoprotein
alias: SLP-76
alias: lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
alias: lymphocyte cytosolic protein 2
alias: SH2 domain-containing leukocyte protein of 76 kDa
alias: SLP76
alias: lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
title: LCP2
hgnc name: LCP2
URN: urn:edrn:bmdb:biomarker:926
description: LCP2, previously known as SLP76, functions as an adaptor or scaffolding protein. LCP2 has three modular domains. The amino-terminal end has an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. LCP2 also contains a central proline-rich domain and a COOH-terminal SH2 domain.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/3937
references resource: Q13094

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/233
type: Biomarker
alias: IL10
alias: interleukin 10
alias: CSIF
alias: cytokine synthesis inhibitory factor
alias: IL-10
alias: IL10A
alias: T-cell growth inhibitory factor
alias: TGIF
alias: Interleukin-10
title: IL10
hgnc name: IL10
URN: urn:edrn:bmdb:biomarker:233
description: From NCBI Gene: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lokshin University of Pittsburgh Cancer Institute
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: !/hgnc id/HGNC:5962
references resource: P22301
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000563.1
references resource: http://www.ncbi.nlm.nih.gov/gene/3586
references resource: http://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1603
type: Biomarker
alias: test again
title: test again
URN: urn:edrn:bmdb:biomarker:1603
is panel: 0

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/963
type: Biomarker
alias: XPOT
alias: XPO3
alias: tRNA exportin
alias: exportin-T
alias: exportin(tRNA)
alias: Exportin(tRNA)
alias: exportin, tRNA (nuclear export receptor for tRNAs)
title: XPOT
hgnc name: XPOT
URN: urn:edrn:bmdb:biomarker:963
description: XPOT, or exportin-T, belongs to the RAN-GTPase exportin family. This protein facilitates export of tRNA from the nucleus to the cytoplasm. XPOT shuttles between the nucleus and the cytoplasm, transporting the aminoacylated tRNAs out of the nucleus, and returning back for another round.
QA state: Curated
phase: 2
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/11260
references resource: O43592

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/386
type: Biomarker
alias: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
alias: SLC11A1
alias: NRAMP
alias: P49279
alias: LSH
alias: solute carrier family 11 (sodium/phosphate symporters), member 1
alias: NRAMP1
alias: NRAMP 1
alias: natural resistance-associated macrophage protein 1
title: SLC11A1
hgnc name: SLC11A1
URN: urn:edrn:bmdb:biomarker:386
description: SLC11A1 is a membrane associated divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. SLC11A1 is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family. Mutations in the SLC11A1 gene are involved in susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Several alternatively spliced variants have been identified.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Godwin University of Kansas Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: !/hgnc id/HGNC:10907
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/6556
references resource: P49279

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/968
type: Biomarker
alias: SERPINE1
alias: Serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1
alias: PAI1
alias: PLANH1
alias: PAI
alias: Serine (Or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1
alias: Serpin E1
alias: PAI-1
alias: Plasminogen Activator Inhibitor 1
alias: Endothelial plasminogen activator inhibitor
alias: tPAI1
alias: tPAI-1
title: SERPINE1
hgnc name: SERPINE1
URN: urn:edrn:bmdb:biomarker:968
description: The SERPINE1 protein is a serine proteinase inhibitor (serpin) superfamily. SERPINE1 is the main inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis. It is found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/175
references resource: http://www.ncbi.nlm.nih.gov/gene/5054
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: !/hgnc id/HGNC:8583
references resource: P05121

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/552
type: Biomarker
alias: Boeri miRNA signature of diagnosis of lung cancer
title: Boeri miRNA signature of diagnosis of lung cancer
URN: urn:edrn:bmdb:biomarker:552
description: miRNA expression analyses in plasma samples collected 1-2 years before the onset of disease, at the time of CT detection and in disease-free smokers enrolled in the screening trial, resulted in the generation of miRNA signatures with strong predictive, diagnostic, and prognostic potential (area under the ROC curve > or = 0.85). The signature of diagnosis of lung cancer is comprised of 16 ratios composed from 13 miRNAs: 21, 92a, 140-3p, 17, 106a, 140-5p, 660, 19b, 451, 30c, 15b, 28-3p, 486-5p. (from PMID:21300873)
QA state: Curated
security: Public
type: Proteomic
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/153

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/841
type: Biomarker
alias: STOM
alias: BND7
alias: erythrocyte band 7 integral membrane protein
alias: Protein 7.2b
alias: erythrocyte membrane protein band 7.2 (stomatin)
alias: EPB7
alias: EPB72
alias: Stomatin
alias: protein 7.2b
alias: stomatin
alias: erythrocyte surface protein band 7.2
title: STOM
hgnc name: STOM
URN: urn:edrn:bmdb:biomarker:841
description: STOM, or stomatin, is an integral membrane protein located in the cell membrane of red blood cells and other cell types, where it is thought to regulate ion channels and transporters. Multiple transcript variants are produced by alternative splicing.
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/2040
references resource: P27105

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/551
type: Biomarker
alias: Boeri miRNA signature of risk for lung cancer
title: Boeri miRNA signature of risk for lung cancer
URN: urn:edrn:bmdb:biomarker:551
description: miRNA expression analyses in plasma samples collected 1-2 years before the onset of disease, at the time of CT detection and in disease-free smokers enrolled in the screening trial, resulted in the generation of miRNA signatures with strong predictive, diagnostic, and prognostic potential (area under the ROC curve > or = 0.85). The signature of diagnosis of lung cancer is comprised of 16 ratios composed from 13 miRNAs: 21, 92a, 140-3p, 17, 106a, 140-5p, 660, 19b, 451, 30c, 15b, 28-3p, 486-5p. (from PMID:21300873)
QA state: Curated
security: Public
type: Proteomic
is panel: 1
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/153

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/126
type: Biomarker
alias: ECM1
alias: extracellular matrix protein 1
alias: Secretory component p85
title: ECM1
hgnc name: ECM1
URN: urn:edrn:bmdb:biomarker:126
description: ECM1 is an extracellular protein containing motifs with a cysteine pattern characteristic of the cysteine pattern of the ligand-binding "double-loop" domains of the albumin protein family. It is involved in endochondral bone formation as negative regulator of bone mineralization. EMC1 stimulates the proliferation of endothelial cells and promotes angiogenesis. It also inhibits MMP9 proteolytic activity. ECM1 is expressed in breast cancer tissues, however little or no expression observed in normal breast tissues. It is also expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
QA state: Curated
security: Public
type: Protein
is panel: 0
access granted to: Crichton JPL
access granted to: Curators
access granted to: Diamandis Mount Sinai Hospital
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/191
references resource: !/hgnc id/HGNC:3153
references resource: https://www.ncbi.nlm.nih.gov/gene/1893
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1591
type: Biomarker
alias: Mercola 131 probe-set classifer panel for prostate cancer
title: Mercola 131 probe-set classifer panel for prostate cancer
URN: urn:edrn:bmdb:biomarker:1591
description: From PMID 21459804: A stroma-specific classifier for nearby tumor was constructed on the basis of 114 candidate genes. The resulting significantly differentially expressed genes for the comparison of normal prostate biopsies to tumor-bearing prostate tissue were used for development of the diagnostic classifier.
QA state: Curated
security: Public
type: Gene
is panel: 1
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/543
type: Biomarker
alias: TMPRSS2:ERG
alias: T2S:ERG
alias: T2:ERG
title: TMPRSS2:ERG
URN: urn:edrn:bmdb:biomarker:543
description: TMPRSS2:ERG gene fusions are a common genetic event in prostate cancer. These fusions are specific for prostate cancer and have also been observed in precursor lesions. Since TMPRSS2:ERG fusions are not seen in every prostate cancer, their utility is in assays combined with other biomarkers, such as PCA3.
QA state: Curated
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/970
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1075
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/129
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/130
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/140
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/141
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/147
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/188
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/7113
references resource: http://www.ncbi.nlm.nih.gov/gene/2078
references resource: O15393
references resource: P11308

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/970
type: Biomarker
alias: Chinnaiyan 7-marker panel for prostate cancer
alias: Chinnaiyan 7 marker panel for prostate cancer
alias: Chinnaiyan (Laxman) 7-marker panel for prostate cancer
alias: Chinnaiyan (Laxman) 7 marker panel for prostate cancer
title: Chinnaiyan (Laxman) 7 marker panel for prostate cancer
URN: urn:edrn:bmdb:biomarker:970
description: This 7-marker multiplex panel of urine transcripts outperforms PCA3 transcript alone for the detection of prostate cancer. The panel consists of PCA3, AMACR, ERG, GP73 (GOLPH2), SPINK1, TFF3, and TMPRSS2:ERG fusion.
QA state: Curated
security: Public
type: Gene
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/63
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/86
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/119
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/543
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/544
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/545
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/546
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/129

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1075
type: Biomarker
alias: MiPS (Mi Prostate Score Urine test)
alias: MPS
title: MiPS (Mi Prostate Score Urine test)
URN: urn:edrn:bmdb:biomarker:1075
description: The MiPS assay is a multiplex analysis of T2-ERG gene fusion, PCA3, and serum PSA (KLK3). It is commercially available through the University of Michigan MLabs. The MiPS assay tests for the presence of two prostate cancer biomarkers: a piece of RNA made from the PCA3 gene, found to be overactive in 95 percent of all prostate cancers, and another RNA marker that is found only when TMPRSS2 and ERG abnormally fuse. TMPRSS2:ERG, or T2-ERG, is a strong indicator of prostate cancer.
QA state: Curated
security: Public
type: Genomic
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/63
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/543
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1051
access granted to: Chinnaiyan University of Michigan
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
access granted to: Wei University of Michigan
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/95
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/97
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/129
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/130
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/140
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/141
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/147
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/188
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/247
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/253
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/288
references resource: available-tests

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
type: Biomarker
alias: MyProstateScore 2.0
alias: MPS2
title: MyProstateScore 2.0
URN: urn:edrn:bmdb:biomarker:1594
description: From lynxdx.com: MyProstateScore 2.0 (MPS2) is a non invasive, genetically data-driven prostate cancer screening solution that provides highly accurate, stratified risk assessment insights to guide clinical decisions and improve your patients’ experience. The MPS2 algorithm has been developed to optimize accuracy. For biopsy naïve patients, MPS2 is a standalone biomarker test. For patients with a prior negative biopsy, relevant clinical factors are included in the algorithm. MPS2 is a urine test designed to predict the presence of clinically significant prostate cancer (Grade Group ≥2 or Gleason score ≥7) by analyzing a comprehensive array of 18 unique gene transcripts. Among the transcripts, the test’s foundation is the novel gene fusion, T2:ERG.
QA state: Curated
security: Public
type: Genomic
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/57
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/63
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/71
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/543
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/544
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/546
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/857
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1051
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1131
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1133
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1135
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1269
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1595
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1596
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1597
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1598
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1599
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1600
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/288
references resource: LynxDx-MPS2-Provider-Brochure.pdf

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/421
type: Biomarker
alias: CSTA
alias: Cystatin-AS
alias: STFA
alias: STF1
alias: cystatin AS
alias: AREI
alias: cystatin A (stefin A)
alias: cystatin-A
alias: Stefin-A
title: CSTA
hgnc name: CSTA
URN: urn:edrn:bmdb:biomarker:421
description: CSTA, or cystatin-A, is a member of the cystatin superfamily, which includes proteins that contain multiple cystatin-like sequences. Some members of the cystatin superfamily are active cysteine protease inhibitors, of which there are three families: type 1 cystatins (stefins), type 2 cystatins, and kininogens. CSTA is a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. Stefins have been proposed as prognostic and diagnostic biomarkers for cancer.
QA state: Curated
security: Public
type: Proteomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/504
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/114
references resource: !/hgnc id/HGNC:2481
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P01040
references resource: http://www.ncbi.nlm.nih.gov/gene/1475

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/504
type: Biomarker
alias: Rahman 9-marker MALDI MS panel for Lung Cancer
alias: Rahman 9 marker MALDI MS panel for Lung Cancer
title: Rahman 9 marker MALDI MS panel for Lung Cancer
URN: urn:edrn:bmdb:biomarker:504
description: This panel was derived from the proteomic analysis of bronchial lesions that could predict the diagnosis of lung cancer. Nine matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) mass to charge ratio features were selected to build a prediction model diagnostic of lung cancer. One signature was not able to be associated with a particular protein. The remaining eight signatures are derived from: Thymosin beta-4 (TMSB4X), Macrophage migration inhibitory factor (MIF), Des-ubiquitin (Ubiquitin-Gly-Gly), Ubiquitin, Acyl-coA binding protein (ACBP, also known as DBI), Cystatin A (CSTA), and Cytochrome c.
QA state: Curated
security: Public
type: Proteomic
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/81
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/402
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/421
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/424
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/427
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/495
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1089
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/114

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/450
type: Biomarker
alias: LRIG3
alias: FLJ90440
alias: leucine-rich repeats and immunoglobulin-like domains protein 3
alias: leucine-rich repeats and immunoglobulin-like domains 3
alias: KIAA3016
alias: LIG-3
alias: LIG3
alias: LIRG3
title: LRIG3
hgnc name: LRIG3
URN: urn:edrn:bmdb:biomarker:450
description: The LRIG3 protein is a widely expressed type I membrane protein. It contains three Ig-like C2-type (immunoglobulin-like) domains, 15 LRR (leucine-rich) repeats, 1 LRRCT domain, and 1 LRRNT domain.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/186
references resource: !/hgnc id/HGNC:30991
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q6UXM1
references resource: NP 700356.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
type: Biomarker
alias: Ostroff 12-marker panel for lung cancer
alias: Aptamer-based markers
alias: Somalogic 12-marker panel for lung cancer
alias: Somalogic 12 marker panel for lung cancer
title: Somalogic 12 marker panel for lung cancer
URN: urn:edrn:bmdb:biomarker:972
description: From PMID 21170350: The sensitivity and specificity of our 12-biomarker panel improves upon published protein and gene expression panels. The 12-protein panel consists of cadherin-1 (CDH1), CD30 ligand (TNFSF8), endostatin, HSP90a, LRIG3, MIP-4 (CCL18), pleiotrophin, PRKCI, RGM-C (HFE2), SCF-sR (KIT), sL-selectin (SELL), and YES. The panel discriminates NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.
QA state: Curated
security: Public
type: Proteomic
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/114
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/413
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/429
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/444
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/450
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/454
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/477
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/479
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/483
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/488
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/492
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/501
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/503
type: Biomarker
alias: Massion 4-marker FISH panel for lung cancer
alias: Massion 4 marker FISH panel for lung cancer
title: Massion 4 marker FISH panel for lung cancer
URN: urn:edrn:bmdb:biomarker:503
description: The combination of these 4 probes, TP63, MYC, CEP3, and CEP6, offered a sensitivity of 82% for lung cancer and a specificity of 58%. These results indicate that specific cytogenetic alterations present in preinvasive lung lesions are closely associated with the diagnosis of lung cancer and may therefore have value in assessing lung cancer risk.
QA state: Curated
security: Public
type: Genomic
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/415
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/416
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/466
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/497
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/101

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/466
type: Biomarker
alias: MYC
alias: c-Myc
alias: Myc proto-oncogene protein
alias: v-myc myelocytomatosis viral oncogene homolog (avian)
alias: bHLHe39
alias: v-myc avian myelocytomatosis viral oncogene homolog
alias: Class E basic helix-loop-helix protein 39
alias: Proto-oncogene c-Myc
alias: Transcription factor p64
alias: MRTL
alias: avian myelocytomatosis viral oncogene homolog
alias: myc proto-oncogene protein
alias: myc-related translation/localization regulatory factor
alias: BHLHE39
alias: cmyc
title: MYC
hgnc name: MYC
URN: urn:edrn:bmdb:biomarker:466
description: The oncogenic protein MYC, previously known as c-MYC, is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It participates in the regulation of gene transcription of specific target genes. MYC binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of the MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. Evidence shows that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini.
QA state: Curated
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/503
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: Massion Vanderbilt University Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/101
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/116
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
references resource: !/hgnc id/HGNC:7553
references resource: P01106
references resource: http://www.ncbi.nlm.nih.gov/gene/4609
references resource: http://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/564
type: Biomarker
alias: ALDH1A2
alias: RALDH2
alias: retinal dehydrogenase 2
alias: Retinaldehyde-specific dehydrogenase type 2
alias: RALDH 2
alias: aldehyde dehydrogenase 1 family, member A2
alias: RALDH(II)
alias: RalDH2
alias: Aldehyde dehydrogenase family 1 member A2
alias: retinaldehyde-specific dehydrogenase type 2
alias: RALDH2-T
alias: EC 1.2.1.36
title: ALDH1A2
hgnc name: ALDH1A2
URN: urn:edrn:bmdb:biomarker:564
description: From NCBI Gene: This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1013
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/235
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/8854
references resource: O94788
references resource: http://omim.org/entry/602847

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1013
type: Biomarker
alias: Marks 7-gene signature for prostate cancer
alias: Mercola 7-gene signature for prostate cancer
title: Mercola 7-gene signature for prostate cancer
hgnc name: Mercola 7-gene signature for prostate cancer
URN: urn:edrn:bmdb:biomarker:1013
description: Significance Analysis of Microarray (SAM) was used to develop a 7-gene classifier. The overall prediction accuracy and sensitivity is 71% and 76%, respectively. The inclusion of the Gleason sum to the seven-gene classifier raised the prediction accuracy and sensitivity to 83% and 76% respectively This prognostic signature is closely associated with biochemical recurrence in patients after radical prostatectomy. The seven genes are: RRAGD, PQBP1, HIST1H2BC, ALDH1A2, TRIM22, RBPMS, HSPB8.
QA state: Curated
security: Public
type: Gene
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/564
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/683
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/698
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/779
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/793
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/802
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/868
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/683
type: Biomarker
alias: HIST1H2BC
alias: Histone H2B.A
alias: Histone H2B.L
alias: Histone H2B.1 A
alias: Histone 1, H2bc
alias: Histone Cluster 1, H2bc
alias: Histone H2B Type 1-C/E/F/G/I
alias: H2B Histone Family, Member L
alias: Histone Cluster 1 H2B Family Member C
alias: H2BFL
alias: H2B.1
alias: H2B/L
alias: H2B Clustered Histone 4
alias: H2BC4
alias: Histone H2B.G
alias: Histone H2B.H
alias: Histone H2B.K
alias: DJ221C16.3
alias: HIST1H2BE
alias: HIST1H2BF
alias: HIST1H2BG
alias: HIST1H2BI
alias: H2BC10
alias: H2BC6
alias: H2BC7
alias: H2BC8
alias: H2BFH
alias: H2BFG
alias: H2BFA
alias: H2BFK
alias: H2B/A
alias: H2B/G
alias: H2B/H
alias: H2B/K
title: H2BC4
hgnc name: H2BC4
URN: urn:edrn:bmdb:biomarker:683
description: This gene was formerly known as HIST1H2BC. From NCBI Gene: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. The main transcript variant of this gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. This transcript variant lacks a polyA tail but instead contains a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Apr 2020]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1013
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: !/hgnc id/HGNC:4757
references resource: https://www.ncbi.nlm.nih.gov/gene/8347
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: P62807

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/223
type: Biomarker
alias: APOA1
alias: apolipoprotein A-I
alias: MGC117399
alias: Apolipoprotein A-I
alias: Apo-AI
alias: ApoA-I
alias: Apolipoprotein A1
alias: Apolipoproteins (Apo) A1
title: APOA1
hgnc name: APOA1
URN: urn:edrn:bmdb:biomarker:223
description: APOA1, a secreted protein belonging to the apolipoprotein A1/A4/E family, participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, APOA1 activates spermatozoa motility. This protein is a major protein of plasma HDL and is also found in chylomicrons. It is synthesized in the liver and small intestine. Defects in APOA1 are a cause of several diseases: 1) high density lipoprotein deficiency type 2 (HDLD2), also known as familial hypoalphalipoproteinemia, for which inheritance is autosomal dominant; 2) the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1), also known as analphalipoproteinemia or Tangier disease (TGD), a recessive disorder characterized by the absence of plasma HDL, accumulation of cholesteryl esters, premature coronary artery disease, hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness; 3) amyloid polyneuropathy-nephropathy Iowa type (AMYLIOWA), also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III, a hereditary generalized amyloidosis due to deposition of amyloid mainly constituted by apolipoprotein A1; 4) amyloidosis type 8 (AMYL8), also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis, a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids.
QA state: Curated
security: Public
type: Proteomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/547
access granted to: Bast MD Anderson
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:600
references resource: P02647
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000030.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/547
type: Biomarker
alias: OVA1
title: OVA1
URN: urn:edrn:bmdb:biomarker:547
description: The OVA1 diagnostic test is comprised of five biomarkers: CA125, transthyretin (prealbumin), apolipprotein A1 (Apo A-1), beta-2 microglobulin, and transferrin. OVA1 is an In Vitro Diagnostic Multivariate Index Assay (IVDMIA) of Proteomic Biomarkers test that analyzes the serum levels of these five proteomic biomarkers. OVA1 is the first FDA approved test for assessing ovarian cancer risk in women previously diagnosed with an ovarian mass, and already scheduled for surgery. The OVA1 algorithm combines the results of these levels with information on the menopause status of the patient to classify the patient into a low- or high-risk group. The results of the OVA1 test can help determine patients needing referral to a gynecologic oncologist for their surgery.
QA state: Curated
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/20
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/72
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/73
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/74
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/223
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/143
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/144
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/167
references resource: 225318.php

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
type: Biomarker
alias: Meltzer 8-marker panel for Esophageal Adenocarcinoma
alias: 8-gene Panel for Barrett's Esophagus
alias: 8 Gene Panel for Barretts Esophagus
title: 8 Gene Panel for Barretts Esophagus
URN: urn:edrn:bmdb:biomarker:53
description: Eight methylation biomarkers - p16, RUNX3, HPP1 (HGNC name TMEFF2), NELL1, TAC1, SST, AKAP12 and CDH13 - were tested in a restrospective multicenter double-blinded validation study for their accuracy in predicting neoplastic progression in Barretts Esophagus. Hypermethylation of p16, RUNX3 and HPP1 has been show to occur in early Barretts Esophagus-related neoplastic progression and predicts progression risk. Several of the panel (NELL1, TAC1, SST, AKAP12 and CDH13) were also shown to be methylated early and often in Barretts Esophagus-related neoplastic progression.
QA state: Accepted
security: Public
type: Genomic
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/45
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/46
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/47
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/48
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/49
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/50
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/51
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/52
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Meltzer Johns Hopkins University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/49
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/51
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/54
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/56
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/74
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/53/52

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/45
type: Biomarker
alias: CDH13
alias: cadherin 13
alias: H-cadherin (heart)
alias: P105
alias: T-cad
alias: H-cadherin
alias: T-cadherin
alias: heart-cadherin
alias: truncated-cadherin
title: CDH13
hgnc name: CDH13
URN: urn:edrn:bmdb:biomarker:45
description: CDH13 is a member of the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region but, unlike the typical cadherin superfamily member, lacks the highly conserved cytoplasmic region. This particular cadherin is a putative mediator of cell-cell interaction in the heart and may act as a negative regulator of neural cell growth. The gene locus is hypermethylated or deleted in breast, ovarian and lung cancers.
QA state: Accepted
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Meltzer Johns Hopkins University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/49
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/50
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/51
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/109
references resource: !/hgnc id/HGNC:1753
references resource: P55290
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000140945
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/66
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/331
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/45/44

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/46
type: Biomarker
alias: NELL1
alias: Protein kinase C-binding protein NELL1
alias: NEL-like protein 1
alias: Nel-related protein 1
alias: NRP1
alias: nel-like 1
title: NELL1
hgnc name: NELL1
URN: urn:edrn:bmdb:biomarker:46
description: NELL1 is a cytoplasmic protein that contains epidermal growth factor (EGF)-like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation.
QA state: Accepted
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Meltzer Johns Hopkins University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/51
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/52
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
references resource: Q92832
references resource: !/hgnc id/HGNC:7750
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000165973
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/67
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/46/45

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/47
type: Biomarker
alias: TAC1
alias: tachykinin-1
alias: tachykinin, precursor 1
alias: neurokinin 1
alias: neurokinin 2
alias: neuromedin L
alias: neurokinin alpha
alias: neuropeptide K
alias: neuropeptide gamma
alias: NPK
alias: TKN1
alias: PPT
alias: Protachykinin-1
alias: TAC2
alias: NKNA
alias: substance P
alias: substance K
alias: tachykinin
title: TAC1
hgnc name: TAC1
URN: urn:edrn:bmdb:biomarker:47
description: The tachykinin gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These active peptides are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Multiple transcript variants encoding different isoforms have been found for this gene.
QA state: Accepted
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: GI and Other Associated
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/51
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/60
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/62
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/63
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
references resource: P20366
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: !/hgnc id/HGNC:11517
references resource: ENSG00000006128
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/68
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/47/46

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/48
type: Biomarker
alias: p16
alias: CDKN2A
alias: CDKN2
alias: MTS1
alias: Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3
alias: Cyclin-dependent kinase 4 inhibitor A
alias: p16-INK4a
alias: Multiple tumor suppressor 1
alias: CDK4I
alias: INK4a
alias: CMM2
alias: p19
alias: INK4
alias: p16INK4a
alias: CDKN2A (p16)
title: CDKN2A (p16)
hgnc name: CDKN2A
URN: urn:edrn:bmdb:biomarker:48
description: From NCBI Gene: This gene (CDKN2A) generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
QA state: Curated
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/90
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/91
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/53
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/54
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/64
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/137
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/287
references resource: http://http://www.genecards.org/cgi-bin/carddisp.pl
references resource: !/hgnc id/HGNC:1787
references resource: ENSG00000147889
references resource: http://www.ncbi.nlm.nih.gov/gene/1029
references resource: P42771

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/49
type: Biomarker
alias: RUNX3
alias: Runt-related transcription factor 3
alias: Core-binding factor subunit alpha-3
alias: CBF-alpha-3
alias: Acute myeloid leukemia 2 protein
alias: Oncogene AML-2
alias: Polyomavirus enhancer-binding protein 2 alpha C subunit
alias: PEBP2-alpha C
alias: PEA2-alpha C
alias: SL3-3 enhancer factor 1 alpha C subunit
alias: SL3/AKV core-binding factor alpha C subunit
alias: AML2
alias: CBFA3
alias: PEBP2A3
title: RUNX3
hgnc name: RUNX3
URN: urn:edrn:bmdb:biomarker:49
description: RUNX3 is a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
QA state: Accepted
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/90
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/91
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/49
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/51
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/53
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/54
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/109
references resource: Q13761
references resource: !/hgnc id/HGNC:10473
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000020633
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/864
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/69
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/332
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/49/48

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/50
type: Biomarker
alias: HPP1
alias: TMEFF2
alias: TENB2
alias: TR
alias: TPEF
alias: tomoregulin
alias: transmembrane protein TENB2
alias: transmembrane protein with EGF-like and two follistatin-like domains 2
alias: Tomoregulin-2
alias: Hyperplastic polyposis protein 1
alias: CT120.2
alias: TR-2
alias: cancer/testis antigen family 120, member 2
title: TMEFF2
hgnc name: TMEFF2
URN: urn:edrn:bmdb:biomarker:50
description: HPP1 (also called TMEFF2) may be a survival factor for hippocampal and mesencephalic neurons. The shedded form (generated by proteolytic shedding) up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. HPP1 is down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with HPP1 silencing in tumor cell lines.
QA state: Accepted
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/90
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/91
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Meltzer Johns Hopkins University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/49
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/51
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/53
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/54
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/57
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/58
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
references resource: !/hgnc id/HGNC:11867
references resource: Q9UIK5
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000144339
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/70
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/50/49

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/51
type: Biomarker
alias: SST
alias: somatostatin
alias: Growth hormone release-inhibiting factor
alias: Somatostatin-28
alias: Somatostatin-14
title: SST
hgnc name: SST
URN: urn:edrn:bmdb:biomarker:51
description: The hormone somatostatin (SST) has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. The promoter of somatostatin, a primary inhibitor of gastrin-stimulated gastric acid secretion, is hypermethylated in 80% of human colon cancers. A synthetic analog of SST, known as octreotide or SMS 201-995, is available under the name Sandostatin (Novartis). It is used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.
QA state: Accepted
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Meltzer Johns Hopkins University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/51
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/55
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/60
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
references resource: P61278
references resource: !/hgnc id/HGNC:11329
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000157005
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/72
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/51/50

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/52
type: Biomarker
alias: AKAP12
alias: A-kinase anchor protein 12
alias: Gravin
alias: Myasthenia gravis autoantigen
alias: A-kinase anchor protein 250 kDa
alias: AKAP250
title: AKAP12
hgnc name: AKAP12
URN: urn:edrn:bmdb:biomarker:52
description: AKAP12 is a member of the A-kinase anchor protein (AKAP) family, a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP12 is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. AKAP12 is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
QA state: Accepted
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/53
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Meltzer Johns Hopkins University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/51
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/59
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/60
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/61
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/81
references resource: !/hgnc id/HGNC:370
references resource: Q02952
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000131016
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/73
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/52/51

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/74
type: Biomarker
alias: B2M
alias: beta-2-microglobulin
alias: CDABP0092
alias: HDCMA22P
alias: Beta Chain Of MHC Class I Molecules
alias: Beta-2-Microglobin
alias: IMD43
title: B2M
hgnc name: B2M
URN: urn:edrn:bmdb:biomarker:74
description: B2M, a secreted protein belonging to the beta-2-microglobulin family, is a component of the class I major histocompatibility complex (MHC) on the surface of nearly all nucleated cells and involved in the presentation of peptide antigens to the immune system. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia. B2M is detected in serum and urine.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/547
access granted to: Bast MD Anderson
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:914
references resource: P61769
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 004039.1
references resource: https://www.ncbi.nlm.nih.gov/gene/567

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/71
type: Biomarker
alias: spondin 2
alias: SPON2
alias: DIL1
alias: DIL-1
alias: Mindin
alias: FLJ16313
alias: FLJ22401
alias: FLJ34460
alias: M-spondin
alias: spondin 2, extracellular matrix protein
alias: Differentially expressed in cancerous and non-cancerous lung cells 1
alias: Spondin-2
title: SPON2
hgnc name: SPON2
URN: urn:edrn:bmdb:biomarker:71
description: SPON2, also known as spondin-2, is a cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. It binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Spondin-2 is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the extacellular matrix for microbial pathogens. Spondin-2 also binds bacterial lipopolysaccharide.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: McIntosh Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:11253
references resource: Q9BUD6
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 036577.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/72
type: Biomarker
alias: TT
alias: TTR
alias: Prealbumin, Amyloidosis Type I
alias: CTS
alias: PALB
alias: HsT2651
alias: Transthyretin
alias: ATTR
alias: CTS1
alias: TBPA
alias: Epididymis Luminal Protein 111
alias: Thyroxine-Binding Prealbumin
alias: Carpal Tunnel Syndrome 1
alias: Prealbumin
alias: HEL111
alias: TTN
title: TTR
hgnc name: TTR
URN: urn:edrn:bmdb:biomarker:72
description: Transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid, is a carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. TT consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/547
access granted to: Bast MD Anderson
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:12405
references resource: P02766
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 000362.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1600
type: Biomarker
alias: HOXC6
alias: Homeobox C6
alias: HOX3C
alias: Homeobox Protein Hox-C6
alias: Homeobox Protein HHO.C8
alias: Homeobox Protein Hox-3C
alias: Homeobox Protein CP25
alias: HOX3
alias: Homeo Box C8 Protein
alias: Homeo Box C6
alias: Homeo Box 3C
alias: HHO.C8
alias: CP25
title: HOXC6
hgnc name: HOXC6
URN: urn:edrn:bmdb:biomarker:1600
description: From NCBI Gene: This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]
QA state: New
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Chinnaiyan University of Michigan
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/288
references resource: !/hgnc id/HGNC:5128
references resource: https://www.ncbi.nlm.nih.gov/gene/3223
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/698
type: Biomarker
alias: HSPB8
alias: DHMN2
alias: heat shock protein beta-8
alias: HSP22
alias: protein kinase H11
alias: Small stress protein-like protein HSP22
alias: CMT2L
alias: Alpha-crystallin C chain
alias: CRYAC
alias: HMN2A
alias: Protein kinase H11
alias: E2-induced gene 1 protein
alias: HspB8
alias: heat shock 22kDa protein 8
alias: H11
alias: small stress protein-like protein HSP22
alias: heat shock 27kDa protein 8
alias: E2IG1
alias: alpha-crystallin C chain
alias: HMN2
title: HSPB8
hgnc name: HSPB8
URN: urn:edrn:bmdb:biomarker:698
description: From NCBI Gene: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1013
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/26353
references resource: Q9UJY1
references resource: http://omim.org/entry/608014

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1080
type: Biomarker
alias: PXN
alias: Paxillin
title: PXN
hgnc name: PXN
URN: urn:edrn:bmdb:biomarker:1080
description: From NCBI Entrez Gene: This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/505
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/115
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/5829
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P49023

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/505
type: Biomarker
alias: Zhong 5-antibody panel for Lung Cancer
alias: Zhong 5 antibody panel for Lung Cancer
title: Zhong 5 antibody panel for Lung Cancer
URN: urn:edrn:bmdb:biomarker:505
description: A potential autoantibody profile was developed to screen for non-small cell lung cancer. 212 immunogenic phage-expressed proteins were statistically ranked for their individual reactivity with 23 stage I cancer patient and 23 risk-matched control samples. Measurements of the five most predictive antibody markers in 46 cases and controls were combined. While the identity of these phage-expressed proteins is not critical for use in a diagnostic assay, the identities were determined through a nucleotide search of GenBank. Markers are: paxillin, SEC 15L2, BAC clone RP11-499F19, XRCC5, and MALAT1.
QA state: Curated
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1080
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1081
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1082
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1083
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1084
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/115

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/501
type: Biomarker
alias: YES
alias: YES1
alias: Yamaguchi Sarcoma Oncogene
alias: Tyrosine-Protein Kinase Yes
alias: Proto-Oncogene Tyrosine-Protein Kinase YES
alias: Cellular Yes-1 Protein
alias: P61-YES
alias: Proto-Oncogene C-Yes
alias: C-YES
alias: HsT441
alias: V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1
title: YES
hgnc name: YES1
URN: urn:edrn:bmdb:biomarker:501
description: YES1, also known as YES, is a non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. It is the cellular homolog of the Yamaguchi sarcoma virus oncogene and belongs to the src family of proteins. YES1 is involved in many phosphorylation reactions, including a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
references resource: !/hgnc id/HGNC:12841
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P07947
references resource: NP 005424.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/779
type: Biomarker
alias: PQBP1
alias: polyglutamine tract-binding protein 1
alias: mental retardation, X-linked 55
alias: polyglutamine binding protein 1
alias: Npw38
alias: MRX55
alias: PQBP-1
alias: nuclear protein containing WW domain 38 kD
alias: Sutherland-Haan X-linked mental retardation syndrome
alias: RENS1
alias: MRXS3
alias: NPW38
alias: MRXS8
alias: 38 kDa nuclear protein containing a WW domain
alias: Polyglutamine tract-binding protein 1
alias: SHS
alias: polyglutamine-binding protein 1
title: PQBP1
hgnc name: PQBP1
URN: urn:edrn:bmdb:biomarker:779
description: From NCBI Gene: This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. The encoded protein contains a WW domain. Mutations in this gene have been found in patients with Renpenning syndrome 1 and other syndromes with X-linked mental retardation. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.[provided by RefSeq, Nov 2009]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1013
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/10084
references resource: O60828
references resource: http://omim.org/entry/300463

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/34
type: Biomarker
alias: 14-3-3 theta
alias: 14-3-3 protein theta
alias: 14-3-3 protein tau
alias: 14-3-3 protein T-cell
alias: Protein HS1
alias: YWHAQ
alias: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
alias: protein tau
alias: 1C5
title: 14-3-3 theta
hgnc name: YWHAQ
URN: urn:edrn:bmdb:biomarker:34
description: YWHAQ, also known as 14-3-3 theta, belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. The 14-3-3 proteins have a wide range of ligands, are involved in a variety of biological pathways, and are known to be overexpressed in some human lung cancers, suggesting that they may play a role in tumorigenesis. 14-3-3 theta is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. It binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 14-3-3 theta antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/39
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Hanash Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/27
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/28
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/29
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/30
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/73
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/137
references resource: P27348
references resource: !/hgnc id/HGNC:12854
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000134308
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/54
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/34/19

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/39
type: Biomarker
alias: Hanash 3-marker panel for Lung Cancer
alias: Hanash 3 marker panel for Lung Cancer
alias: 3-panel (14-3-3 & Annexin & LAMR1)
title: Hanash 3 marker panel for Lung Cancer
URN: urn:edrn:bmdb:biomarker:39
description: The EDRN validation study ("Validation of Protein Markers for Lung Cancer Using CARET Sera and Proteomics Techniques") presents evidence for the occurrence in lung cancer sera of autoantibodies to annexin 1, 14-3-3 theta and LAMR1, which precede the onset of symptoms and diagnosis. The combined AUC for these three antigens in CARET pre-clinical lung cancer sera vs. matched controls was 0.73. While autoantibodies to various cancer antigens have been reported in newly diagnosed lung cancer patient sera, an important aspect of this study is testing for occurrence of autoantibodies in pre-diagnostic sera and demonstration of significant autoantibody reactivity against LAMR1, annexin 1 and 14-3-3 theta.
QA state: Accepted
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/32
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/34
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/35
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Hanash Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/27
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/73
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/60
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/39/1000

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/488
type: Biomarker
alias: SCF-sR
alias: KIT
alias: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
alias: SCFR
alias: CD117 antigen
alias: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
alias: C-Kit
alias: Piebald trait protein
alias: p145 c-kit
alias: proto-oncogene c-Kit
alias: Piebald trait
alias: tyrosine-protein kinase Kit
alias: soluble KIT variant 1
alias: mast/stem cell growth factor receptor Kit
alias: CD117
alias: PBT
alias: proto-oncogene tyrosine-protein kinase Kit
alias: SCFsR
title: KIT
hgnc name: KIT
URN: urn:edrn:bmdb:biomarker:488
description: SCF-sR, also known as KIT, is the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. Human KIT is a tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/163
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/164
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/165
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/220
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/221
references resource: !/hgnc id/HGNC:6342
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: p10721
references resource: NP 000213.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/26
type: Biomarker
alias: MUC1
alias: CA15-3
alias: Mucin 1, Cell Surface Associated
alias: PUM
alias: Tumor-Associated Epithelial Membrane Antigen
alias: Breast Carcinoma-Associated Antigen DF3
alias: Peanut-Reactive Urinary Mucin
alias: Polymorphic Epithelial Mucin
alias: Carcinoma-Associated Mucin
alias: Mucin 1, Transmembrane
alias: Krebs Von Den Lungen-6
alias: Cancer Antigen 15-3
alias: Episialin
alias: CA 15-3
alias: MCKD1
alias: H23AG
alias: MUC-1
alias: KL-6
alias: PEMT
alias: EMA
alias: PEM
alias: Medullary Cystic Kidney Disease 1 (Autosomal Dominant)
alias: Medullary Cystic Kidney Disease, Autosomal Dominant
alias: Tumor Associated Epithelial Mucin
alias: Tumor-Associated Mucin
alias: CD227 Antigen
alias: DF3 Antigen
alias: H23 Antigen
alias: MUC-1/SEC
alias: ADMCKD1
alias: MUC-1/X
alias: MUC1/ZD
alias: Mucin-1
alias: ADMCKD
alias: CD227
alias: MAM6
alias: MCKD
alias: MCD
alias: CA15.3
title: CA15-3
hgnc name: MUC1
URN: urn:edrn:bmdb:biomarker:26
description: From NCBI Gene: This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/89
access granted to: Breast and Gynecologic
access granted to: Cramer Brigham and Women's Hospital
access granted to: Crichton JPL
access granted to: Curators
access granted to: Engstrom Fox Chase Cancer Center
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/15
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/16
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/17
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/116
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/249
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/4582
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P15941
references resource: NP_002447
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/47
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1072
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1098
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1106
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/26/37
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/26/38
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/26/915
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/26/960
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/26/1021
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/26/1642
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/26/1691

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/89
type: Biomarker
alias: Cramer 5-marker panel for ovarian cancer
alias: Cramer 5 marker panel for ovarian cancer
title: Cramer 5 marker panel for ovarian cancer
URN: urn:edrn:bmdb:biomarker:89
description: The PLCO phase III specimens (test half) revealed marker panels produced only marginal improvement over CA 125 alone and, in some case, worse performance. Besides searching for new markers, some ways to improve detection might include: 1) Add epidemiologic variables, and 2) Add in prior markers values.
QA state: Curated
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/20
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/22
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/23
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/24
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/26
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/57
type: Biomarker
alias: hK4
alias: Human kallikrein 4
alias: Kallikrein-4
alias: Prostase
alias: Kallikrein-like protein 1
alias: KLK-L1
alias: Enamel matrix serine proteinase 1
alias: Serine protease 17
alias: KLK4
alias: EMSP1
alias: PRSS17
alias: PSTS
title: KLK4
hgnc name: KLK4
URN: urn:edrn:bmdb:biomarker:57
description: The glandular kallikreins are a distinct group of serine proteases with molecular masses of 25,000 to 40,000. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Several human kallikrein genes have been isolated. hK4 is expressed in the prostate.
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/71
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/72
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/250
references resource: !/hgnc id/HGNC:6365
references resource: Q9Y5K2
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000167749
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/78
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/57/26
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/57/27
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/57/925
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/57/1035

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1083
type: Biomarker
alias: MALAT1
alias: Metastasis Associated Lung Adenocarcinoma Transcript 1 (Non-Protein Coding)
alias: hepcarcin
alias: HCN
alias: LINC00047
alias: MALAT-1
alias: NCRNA00047
alias: NEAT2
alias: PRO2853
alias: mascRNA
alias: PRO1073
alias: Long Intergenic Non-Protein Coding RNA 47
alias: Metastasis Associated In Lung Adenocarcinoma Transcript 1
alias: Non-Protein Coding RNA 47
alias: Nuclear Enriched Abundant Transcript 2
alias: Nuclear Paraspeckle Assembly Transcript 2 (Non-Protein Coding)
title: MALAT1
hgnc name: MALAT1
URN: urn:edrn:bmdb:biomarker:1083
description: MALAT1 is a non-protein coding RNA known to be associated with lung adenocarcinoma.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/505
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/115
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/378938
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q9UHZ2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/24
type: Biomarker
alias: HE4
alias: WAP four-disulfide core domain 2 [Precursor]
alias: WFDC2
alias: WAP5
alias: Major epididymis-specific protein E4
alias: Epididymal secretory protein E4
alias: Putative protease inhibitor WAP5
alias: WAP four-disulfide core domain 2
alias: EDDM4
alias: dJ461P17.6
alias: epididymal protein 4
alias: epididymis-specific, whey-acidic protein type, four-disulfide core
alias: WAP domain containing protein HE4-V4
title: HE4
hgnc name: WFDC2
URN: urn:edrn:bmdb:biomarker:24
description: 11 kDa protein that is a precursor to the epididymal secretory protein HE4; an inhibitor of an as yet unidentified protease. Highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/89
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/966
access granted to: Breast and Gynecologic
access granted to: Cramer Brigham and Women's Hospital
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/12
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/137
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/204
references resource: Q14508
references resource: !/hgnc id/HGNC:15939
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000101443
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/45
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/24/41
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/24/42
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/24/155
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/24/740

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/966
type: Biomarker
alias: ROMA
title: ROMA
URN: urn:edrn:bmdb:biomarker:966
description: The Risk of Ovarian Malignancy Algorithm (ROMA) algorithm was approved by the FDA in 2011. Research demonstrates that examining levels of HE4 and CA125 using the ROMA algorithm shows the highest accuracy in determining ovarian cancer risk in pre- and post-menopausal women who have an ovarian mass present.
QA state: Curated
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/20
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/24
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/166
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/167
references resource: K103358.pdf
references resource: FDA-Clears-Biomarker-Test.cfm

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/19
type: Biomarker
alias: Des-gamma carboxyprothrombin
alias: DCP
alias: Prothrombin Induced by Vitamin K Absence II
alias: PIVKA II
alias: PIVKA-II
title: DCP
URN: urn:edrn:bmdb:biomarker:19
description: Des-gamma-carboxy prothrombin (DCP) is a non-functional precursor of prothrombin. Prothrombin, produced by the liver, serves a critical role in normal hemostasis. Functional prothrombin contains several gamma-carboxy-glutamic acid (Gla) residues that are produced as the result of post-translational modification of glutamic acid residues mediated by vitamin K dependent gamma-glutamyl carboxylase. The formation of Gla residues can be impaired in patients with vitamin K deficiency or in patients receiving oral anticoagulant therapy. DCP lacks thrombotic activity and has been shown in multiple studies to be present in the serum of patients with HCC. DCP arises from an acquired defect in the post-translational carboxylation of the pro-thrombin precursor in malignant hepatocytes.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1124
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1420
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: G.I. and Other Associated
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/23
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/33
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/34
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/132
references resource: Marrero.htm
references resource: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpcd/classification.cfm

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1124
type: Biomarker
alias: DCP and AFP-L3 risk biomarkers for HCC
alias: DCP and AFP-L3 risk biomarkers for HCC (Panel)
title: DCP and AFP-L3 risk biomarkers for HCC
URN: urn:edrn:bmdb:biomarker:1124
description: DCP and AFP-L3 panel for the detection of hepatocellular carcinoma (HCC). DCP (des-gamma carboxy-prothrombin) and AFP-L3 (lectin-bound alpha-fetoprotein) as a panel for detection of HCC.
QA state: Curated
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/19
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/37
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: G.I. and Other Associated
access granted to: Marrero University of Michigan
access granted to: Marrero UT Southwestern Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/33
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/132
references resource: hccbiomarkers.html

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/32
type: Biomarker
alias: Annexin 1
alias: Chromobindin-9
alias: ANXA1
alias: ANX1
alias: LPC1
alias: Lipocortin I
alias: Calpactin II
alias: p35
alias: Phospholipase A2 inhibitory protein
alias: Annexin A1
alias: Annexin-1
alias: Annexin I
title: ANXA1
hgnc name: ANXA1
URN: urn:edrn:bmdb:biomarker:32
description: Annexin 1 belongs to a family of calcium-dependent phospholipid binding proteins which are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. Annexin 1 also promotes membrane fusion and is involved in exocytosis. It seems to bind from two to four calcium ions with high affinity.
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/39
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/508
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Hanash Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/25
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/26
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/27
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/73
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/119
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/137
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
references resource: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi
references resource: P04083
references resource: !/hgnc id/HGNC:533
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000135046
references resource: https://www.ncbi.nlm.nih.gov/gene/301
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/53
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1071
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/32/18
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/32/914

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/508
type: Biomarker
alias: Farlow 6-marker panel for Lung Cancer
alias: Farlow 6 marker panel for Lung Cancer
title: Farlow 6 marker panel for Lung Cancer
URN: urn:edrn:bmdb:biomarker:508
description: This study aimed to develop a serum test that could be used to discern NSCLC patients from cancer-free controls and may provide a means to indicate who should have spiral CT done. A large number of potential tumor autoantibodies for NSCLC were identified and validated. The six-analyte blood test that resulted from this study (consisting of IMPDH, phosphoglycerate mutase, ubiquilin, Annexin I, Annexin II, and HSP70-9B) possessed excellent test performance characteristics when tested against our 196 patient cohort that was composed of four clinically distinct groups, with only 13 patients misclassified overall.
QA state: Curated
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/32
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/115
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/153
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/443
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/446
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/474
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/119

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1081
type: Biomarker
alias: EXOC6B
alias: SEC15L2
alias: Exocyst Complex Component 6B
alias: SEC15B
alias: Exocyst Complex Component Sec15B
alias: SEC15-Like Protein 2
alias: KIAA0919
alias: SEC15 Homolog B (S. Cerevisiae)
alias: SEC15-Like 2 (S. Cerevisiae)
alias: WUGSC:H_NH0343N14.1
alias: SEC15 Homolog B
alias: SEC15-Like 2
title: EXOC6B
hgnc name: EXOC6B
URN: urn:edrn:bmdb:biomarker:1081
description: From NCBI Entrez Gene: In yeast and rat, Sec15 is part of a multiprotein complex that is required for targeted exocytosis.[supplied by OMIM, Apr 2004]
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/494
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/505
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/115
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/23233
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q9Y2D4

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/494
type: Biomarker
alias: Zhong TAA signature
title: Zhong TAA signature
URN: urn:edrn:bmdb:biomarker:494
description: The TAA signature is a diagnostic array of five markers capable of distinguishing patients with non-small cell lung cancer (NSCLC) from normal control subjects. The diagnostic array was developed by enriching and screening phage-expressed tumor-associated proteins, and using these in a fluorescent protein microarray to identify and measure multiple non-small cell lung cancer-associated antibodies and show how simultaneous measurements can be combined into a single diagnostic assay. Although the identity of the phage-expressed proteins is not critical for use in a diagnostic assay, the sequences were compared with the GenBank database to obtain possible identity. The five proteins in the final diagnostic array are GAGE7, BAC clone RP11-499F19, SEC15L2, PMS2P7 (PMS2L15), and EEF1A.
QA state: Curated
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1081
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1084
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1085
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1086
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1087
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/133

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/119
type: Biomarker
alias: AMACR
alias: alpha-methylacyl-CoA racemase
alias: RACE
alias: 2-methylacyl-CoA racemase
alias: CBAS4
alias: RM
alias: AMACRD
title: AMACR
hgnc name: AMACR
URN: urn:edrn:bmdb:biomarker:119
description: AMACR, a racemase, is an enzyme that interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from the gene locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Frequent overexpression of AMACR has been detected in prostate cancer tumors.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/970
access granted to: Chinnaiyan University of Michigan
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/88
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/129
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/249
references resource: http://www.ncbi.nlm.nih.gov/gene/23600
references resource: !/hgnc id/HGNC:451
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q9UHK6

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/37
type: Biomarker
alias: Lectin-bound alpha-fetoprotein
alias: AFP-L3
alias: lectin-bound AFP
title: AFP-L3
hgnc name: AFP-L3
URN: urn:edrn:bmdb:biomarker:37
description: AFP-L3, also known as lectin-bound AFP, is an isoform of AFP, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. The L3 isoform is specific to malignant tumors and its detected presence may serve to identify patients who could benefit from monitoring for the development of HCC in high risk populations (i.e. chronic hepatitis, liver cirrhosis).
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1124
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1420
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: G.I. and Other Associated
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/33
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/36
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/37
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/38
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/132
references resource: !/hgnc id/HGNC:317
references resource: P02771
references resource: NP 001125.1
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: ucm078610.htm

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/20
type: Biomarker
alias: CA125
alias: FLJ14303
alias: Mucin 16
alias: Mucin-16
alias: MUC-16
alias: Ovarian carcinoma antigen CA125
alias: Ovarian cancer-related tumor marker CA125
alias: CA-125
alias: MUC16
alias: mucin 16, cell surface associated
alias: CA125 ovarian cancer antigen
title: CA125
hgnc name: MUC16
URN: urn:edrn:bmdb:biomarker:20
description: From NCBI Gene: This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/89
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/547
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/966
access granted to: Breast and Gynecologic
access granted to: Cramer Brigham and Women's Hospital
access granted to: Crichton Jet Propulsion Laboratory
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/8
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/35
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/254
references resource: http://www.genome.ad.jp/dbget-bin/www_bget
references resource: entry
references resource: !/hgnc id/HGNC:15582
references resource: ENSG00000181143
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/94025
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/41
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1073
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1235
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/55
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/30
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/152
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/257
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/916
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/959
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/1010
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/1736
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/1749
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/1758
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/20/2030

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1085
type: Biomarker
alias: GAGE7
alias: G Antigen 7
alias: Cancer/Testis Antigen 4.7
alias: AL4
alias: CT4.7
alias: GAGE-7
alias: Cancer/Testis Antigen Family 4
alias: Member 7
alias: Cancer/Testis Antigen Family 4, Member 7
alias: G Antigen 12G
alias: GAGE-12I
alias: GAGE-7B
alias: GAGE-8
alias: GAGE12I
alias: GAGE7B
title: GAGE7
hgnc name: GAGE7
URN: urn:edrn:bmdb:biomarker:1085
description: GAGE7 is a member of a family of genes that code for an antigenic peptide, YRPRPRRY. These genes are thought to be expressed in a variety of tumors but not in normal tissues, except for the testis.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/494
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/133
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/238
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/2579
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: O76087

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/507
type: Biomarker
alias: Wu 6-marker phage peptide panel for Lung Cancer
alias: Wu 6 marker phage peptide panel for Lung Cancer
title: Wu 6 marker phage peptide panel for Lung Cancer
URN: urn:edrn:bmdb:biomarker:507
description: The six-phage peptide detector stands out as a promising diagnostic biomarker for NSCLC. The peptide panel could be used to diagnose non-small cell lung cancer and to differentiate between non-small cell lung cancer and chronic obstructive pulmonary diseases. One of the six phage peptides shows 100% homology to olfactomedin 1. (Clin Cancer Res. 2010 Jul 15;16(14):3760-8. doi: 10.1158/1078-0432.CCR-10-0193) The other five peptides were homologous to proteins in a blastp search, but the homology was not high enough to positively identify the peptides.
QA state: Curated
security: Public
type: Protein
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1088
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/118

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1088
type: Biomarker
alias: OLFM1
alias: Olfactomedin 1
alias: Neuronal Olfactomedin-Related ER Localized Protein
alias: NOE1
alias: AMY
alias: pancortin
alias: NOELIN1
alias: OlfA
alias: Neuroblastoma Protein
alias: noelin
alias: Olfactomedin Related ER Localized Protein
alias: olfactomedin-1
alias: Pancortin 1
alias: NOEL1
alias: Olfactomedin-1
title: OLFM1
hgnc name: OLFM1
URN: urn:edrn:bmdb:biomarker:1088
description: From NCBI Entrez Gene: This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/507
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/118

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1595
type: Biomarker
alias: OR51E2
alias: Olfactory Receptor Family 51 Subfamily E Member 2
alias: PSGR
alias: Prostate-Specific G-Protein Coupled Receptor
alias: Olfactory Receptor OR11-16
alias: Olfactory Receptor 51E2
alias: HPRAJ
alias: Olfactory Receptor, Family 51, Subfamily E, Member 3 Pseudogene
alias: Olfactory Receptor, Family 51, Subfamily E, Member 2
alias: Olfactory Receptor, Family 52, Subfamily A, Member 2
alias: OR51E3P
alias: OR52A2
title: OR51E2
hgnc name: OR51E2
URN: urn:edrn:bmdb:biomarker:1595
description: From NCBI Gene: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
QA state: New
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Chinnaiyan University of Michigan
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/288
references resource: !/hgnc id/HGNC:15195
references resource: https://www.ncbi.nlm.nih.gov/gene/81285
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/492
type: Biomarker
alias: sL-selectin
alias: SELL
alias: Leukocyte adhesion molecule 1
alias: Leukocyte surface antigen Leu-8
alias: LAM1
alias: Leukocyte-endothelial cell adhesion molecule 1
alias: lymphocyte adhesion molecule 1
alias: LSEL
alias: LECAM1
alias: LYAM1
alias: gp90-MEL
alias: CD62L antigen
alias: L-selectin
alias: leukocyte surface antigen Leu-8
alias: LNHR
alias: lymph node homing receptor
alias: selectin L
alias: hLHRc
alias: PLNHR
alias: LEU8
alias: LAM-1
alias: TQ1
alias: pln homing receptor
alias: Leu-8
alias: leukocyte-endothelial cell adhesion molecule 1
alias: CD62 antigen-like family member L
alias: Lymph node homing receptor
alias: Lyam-1
alias: CD62L
title: SELL
hgnc name: SELL
URN: urn:edrn:bmdb:biomarker:492
description: From NCBI Gene and UniProtKB/Swiss-Prot: sL-selectin, also known as SELL, is a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. SELL mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes and promotes initial tethering and rolling of leukocytes in endothelia, facilitating their migration into secondary lymphoid organs and inflammation sites. SELL contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. Alternatively spliced transcript variants have been found for this gene.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Anderson Arizona State University
access granted to: Anderson Dana-Farber Cancer Institute
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/127
references resource: !/hgnc id/HGNC:10720
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P14151
references resource: NP 000646.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/456
type: Biomarker
alias: miR-21
alias: mir-21
alias: microRNA 21
alias: miRNA21
alias: hsa-mir-21
alias: MIRN21
alias: MIR21
title: MIR21
hgnc name: MIR21
URN: urn:edrn:bmdb:biomarker:456
description: From NCBI Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. miRNAs bind to complementary sequences in the 3' UTR of multiple target mRNAs, usually silencing the targeted mRNA. miRNAs may trigger the cleavage of their target molecules or act as translational repressors. miRNAs are thought to target approximatley 60% of all genes and are able to repress hundreds of targets each.
QA state: Curated
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/555
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/135
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/136
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/137
references resource: !/hgnc id/HGNC:31586
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/406991

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/555
type: Biomarker
alias: Shen 4-marker miRNA panel for lung cancer
alias: Shen 4 marker miRNA panel for lung cancer
title: Shen 4 marker miRNA panel for lung cancer
URN: urn:edrn:bmdb:biomarker:555
description: We initially validated expressions of a set of miRNAs in paired lung tumor tissues and plasma specimens from 28 stage I NSCLC patients by real-time quantitative reverse transcription PCR, and then evaluated diagnostic value of the plasma miRNAs in a cohort of 58 NSCLC patients and 29 healthy individuals. The altered miRNA expressions were reproducibly confirmed in the tumor tissues. The miRNAs were stably present and reliably measurable in plasma. A logistic regression model with the best prediction was defined on the basis of the four genes (miRNA-21, -126, -210, and 486-5p), yielding 86.22% sensitivity and 96.55% specificity in distinguishing NSCLC patients from the healthy controls. (Lab Invest. 2011 Apr;91(4):579-87, PMID: 21116241)
QA state: Curated
security: Public
type: Genomic
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/398
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/456
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/460
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/462
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/135

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/23
type: Biomarker
alias: B7-H4
alias: Immune costimulatory protein B7-H4
alias: B7h.5
alias: T-cell costimulatory molecule B7x
alias: Protein B7S1
alias: VTCN1
alias: B7H4
alias: V-set domain containing T cell activation inhibitor 1
alias: OV110
alias: DD-0110
alias: B7S1
alias: B7X
alias: VCTN1
alias: FLJ22418
alias: PRO1291
alias: B7 family member, H4
alias: B7 superfamily member 1
title: VTCN1
hgnc name: VTCN1
URN: urn:edrn:bmdb:biomarker:23
description: Highly glycosylated sialomucin; expressed on immune cells. Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Belongs to the B7 family of costimulatory proteins.
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/89
access granted to: Breast and Gynecologic
access granted to: Cramer Brigham and Women's Hospital
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/11
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
references resource: !/hgnc id/HGNC:28873
references resource: Q7Z7D3
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000134258
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/44
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/23/39
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/23/40

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/114
type: Biomarker
alias: CDH1
alias: cadherin 1, type 1, E-cadherin (epithelial)
alias: uvomorulin
alias: UVO
alias: CD324
alias: E-Cadherin
alias: CAM 120/80
alias: Cadherin-1
alias: CDHE
title: CDH1
hgnc name: CDH1
URN: urn:edrn:bmdb:biomarker:114
description: From NCBI Gene: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
access granted to: Sidransky Johns Hopkins University
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/121
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/183
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: http://www.ncbi.nlm.nih.gov/gene/999
references resource: !/hgnc id/HGNC:1748
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P12830
references resource: NP 004351.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/86
type: Biomarker
alias: GP73
alias: golgi membrane protein 1
alias: GOLM1
alias: GOLPH2
alias: C9orf155
alias: golgi phosphoprotein 2
alias: chromosome 9 open reading frame 155
alias: FLJ23608
alias: bA379P1.3
alias: FLJ22634
alias: PSEC0257
title: GP73
hgnc name: GOLM1
URN: urn:edrn:bmdb:biomarker:86
description: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. GP73 is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of the GP73 gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. Kladeny, RD. et al. 2000, found significant up-regulation of GOLPH2 expression in human hepatocyte cells infected with a recombinant adenovirus. EDRN investigator Block, TM et al. 2005, found that GP73 over-expression in serum correlate with liver cancer in woodchucks and humans. Chinnayian's lab reported that GP73 transcript was over-expressed in prostate cancer patients urine sediment (Laxman B. et al. 2008).
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/970
access granted to: Chinnaiyan University of Michigan
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/89
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/90
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/91
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/129
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/180
references resource: http://www.ncbi.nlm.nih.gov/gene/51280
references resource: !/hgnc id/HGNC:15451
references resource: Q8NBJ4

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/429
type: Biomarker
alias: Endostatin
alias: KNO
alias: collagen, type XVIII, alpha 1
alias: KNO1
alias: Knobloch syndrome, type 1
alias: multi-functional protein MFP
alias: human type XVIII collagen
alias: antiangiogenic agent
alias: KS
alias: collagen alpha-1(XVIII) chain
alias: COL18A1
alias: Endostatin (RNDO)
title: Endostatin
hgnc name: COL18A1
URN: urn:edrn:bmdb:biomarker:429
description: COL18A1, also known as endostatin, is the alpha chain of type XVIII collagen. COL18A1 is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. It also inhibits endothelial cell proliferation and angiogenesis, and may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/185
references resource: !/hgnc id/HGNC:2195
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P39060
references resource: NP 085059.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/22
type: Biomarker
alias: CA72-4
alias: tumor-associated glycoprotein 72
alias: TAG-72
alias: Cancer-associated Antigen 72-4
title: CA72-4
URN: urn:edrn:bmdb:biomarker:22
description: High-MW mucin-type glycoprotein expressed on epithelial cancer cells.
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/89
access granted to: Breast and Gynecologic
access granted to: Cramer Brigham and Women's Hospital
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/10
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/43
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/1223
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/22/32
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/22/33
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/22/1690

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/67
type: Biomarker
alias: SLPI
alias: HUSI-I
alias: ALK1
alias: ALP
alias: BLPI
alias: HUSI
alias: WAP4
alias: WFDC4
alias: secretory leukocyte protease inhibitor (antileukoproteinase)
alias: secretory leukocyte peptidase inhibitor
alias: antileukoproteinase
alias: MPI
alias: Seminal proteinase inhibitor
alias: WAP four-disulfide core domain protein 4
alias: Mucus proteinase inhibitor
title: SLPI
hgnc name: SLPI
URN: urn:edrn:bmdb:biomarker:67
description: From NCBI Gene: This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1076
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: McIntosh Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Urban Fred Hutchinson Cancer Research Center
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/84
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/236
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:11092
references resource: P03973
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 003055.1
references resource: https://www.ncbi.nlm.nih.gov/gene/6590

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1076
type: Biomarker
alias: Proteomic Panel for Lung Cancer
title: Proteomic Panel for Lung Cancer
URN: urn:edrn:bmdb:biomarker:1076
description: An immunoaffinity-mass spectrometry-based quantification approach was used to develop an assay for verifying the expression of potential biomarkers in patient serum samples from lung cancer patients.
QA state: Curated
security: Public
type: Proteomic
is panel: 1
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/67
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/104
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/224
has biomarker: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1077
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/236

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/477
type: Biomarker
alias: pleiotrophin
alias: pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
alias: heparin-binding neurite outgrowth-promoting factor 1
alias: neurite growth-promoting factor 1
alias: Heparin-binding growth factor 8
alias: Heparin-binding growth-associated molecule
alias: HARP
alias: HBGF-8
alias: heparin-binding brain mitogen
alias: HBNF
alias: HBNF-1
alias: HBBM
alias: heparin-binding growth factor 8
alias: OSF-1
alias: osteoblast-specific factor 1
alias: HB-GAM
alias: Heparin-binding neurite outgrowth-promoting factor 1
alias: HBNF1
alias: HBGF8
alias: Osteoblast-specific factor 1
alias: heparin affin regulatory protein
alias: heparin binding growth factor 8
alias: heparin-binding growth-associated molecule
alias: Heparin-binding brain mitogen
alias: NEGF1
alias: PTN
title: pleiotrophin
hgnc name: PTN
URN: urn:edrn:bmdb:biomarker:477
description: Pleiotrophin, or PTN, is a secreted growth factor found in osteoblasts and brain tissue. PTN induces neurite outgrowth and is mitogenic for fibroblasts, epithelial, and endothelial cells. It binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
references resource: !/hgnc id/HGNC:9630
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P21246
references resource: NP 002816.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/444
type: Biomarker
alias: HSP90a
alias: HSPCAL4
alias: HSPC1
alias: HSPCA
alias: HSP89A
alias: heat shock 90kD protein 1, alpha-like 4
alias: heat shock protein HSP 90-alpha
alias: Hsp89
alias: HSP 86
alias: HSP90N
alias: HSPCAL1
alias: Heat shock 86 kDa
alias: heat shock 86 kDa
alias: Hsp90
alias: HSP90A
alias: FLJ31884
alias: HSP86
alias: heat shock 90kD protein, alpha-like 4
alias: heat shock protein 90kDa alpha (cytosolic), class A member 1
alias: LAP2
alias: heat shock 90kD protein 1, alpha
alias: heat shock 90kDa protein 1, alpha
alias: Renal carcinoma antigen NY-REN-38
alias: HSPN
alias: renal carcinoma antigen NY-REN-38
alias: HSP90AA1
alias: HSP90alpha
title: HSP90AA1
hgnc name: HSP90AA1
URN: urn:edrn:bmdb:biomarker:444
description: The HSP90AA1 protein, also known as HSP90a, is a molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. HSP90AA1 is a homodimer that assists in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:5253
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P07900
references resource: NP 001017963.2
references resource: JOCM 3(4) 107-112.pdf

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/35
type: Biomarker
alias: LAMR1
alias: RPSA
alias: ribosomal protein SA
alias: laminin receptor 1
alias: laminin receptor 1 (67kD, ribosomal protein SA)
alias: LRP
alias: 37LRP
alias: p40
alias: 34/67 kDa laminin receptor
alias: LamR
alias: Colon carcinoma laminin-binding protein
alias: NEM/1CHD4
alias: Multidrug resistance-associated protein MGr1-Ag
alias: LAMBR
alias: RSSA
alias: Laminin-binding protein precursor p40
alias: 67LR
alias: LBP/p40
alias: LRP/LR
alias: LBP
alias: 40S ribosomal protein SA
alias: 67kD, ribosomal protein SA
title: LAMR1
hgnc name: RPSA
URN: urn:edrn:bmdb:biomarker:35
description: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. The amino acid sequence of laminin receptor 1 is highly through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Cell-adhesive protein LAMR1 plays an important role in the processes of cancer proliferation, invasion and metastasis. LAMR1 antigens have been found to be targets of autoantibodies in subjects newly diagnosed with lung cancer.
QA state: Accepted
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/39
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Hanash Fred Hutchinson Cancer Research Center
access granted to: Lung and Upper Aerodigestive
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/27
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/28
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/73
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/76
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/77
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/78
references resource: http://ca.expasy.org/cgi-bin/niceprot.pl
references resource: !/hgnc id/HGNC:6502
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: ENSG00000168028
indicator for organ: http://edrn.jpl.nasa.gov/bmdb/biomarkers/organs/55
has biomarker study datas:
  item: http://edrn.jpl.nasa.gov/bmdb/biomarkers/studies/35/20

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1051
type: Biomarker
alias: KLK3
alias: kallikrein 3, (prostate specific antigen)
alias: P-30 antigen
alias: Seminin
alias: prostate-specific antigen
alias: kallikrein-related peptidase 3
alias: hK3
alias: prostate specific antigen
alias: seminin
alias: PSA
alias: APS
alias: Semenogelase
alias: kallikrein-3
alias: KLK2A1
alias: semenogelase
alias: Kallikrein-3
alias: Gamma-seminoprotein
alias: gamma-seminoprotein
alias: EC 3.4.21.77
alias: KLK3 (PSA)
title: PSA
hgnc name: KLK3
URN: urn:edrn:bmdb:biomarker:1051
description: KLK3, also known as PSA, or prostate specific antigen, a member of the kallikrein subgroup of serine proteases, is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Kallikreins are increasingly thought to be involved in carcinogenesis, and many act as cancer biomarkers. The product of the KLK3 gene is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum. KLK3, or PSA, is well known for its role in diagnosing and monitoring prostate cancer. There are several isoforms of KLK3, generated by alternate splicing and transcript variants.
QA state: Curated
security: Public
type: Proteomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1075
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Breast and Gynecologic
access granted to: Chan Johns Hopkins Medical Institutions
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/87
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/97
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/249
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/250
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/354
references resource: P07288
references resource: http://omim.org/entry/176820

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/793
type: Biomarker
alias: RBPMS
alias: RNA-binding protein with multiple splicing
alias: Heart and RRM expressed sequence
alias: Hermes
alias: RBP-MS
alias: RNA binding protein with multiple splicing
alias: heart and RRM expressed sequence
alias: HERMES
title: RBPMS
hgnc name: RBPMS
URN: urn:edrn:bmdb:biomarker:793
description: From NCBI Gene: This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1013
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/11030
references resource: Q93062
references resource: http://omim.org/entry/601558

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1597
type: Biomarker
alias: NKAIN1
alias: Sodium/Potassium Transporting ATPase Interacting
alias: Sodium/Potassium-Transporting ATPase Subunit Beta-1-Interacting Protein
alias: FAM77C
alias: Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein
alias: Family With Sequence Similarity 77, Member C
alias: Na+/K+ Transporting ATPase Interacting
alias: FLJ12650
alias: Protein FAM77C
title: NKAIN1
hgnc name: NKAIN1
URN: urn:edrn:bmdb:biomarker:1597
description: From NCBI Gene: NKAIN1 is a member of a family of mammalian proteins with similarity to Drosophila Nkain and interacts with the beta subunit of Na,K-ATPase (ATP1B1; MIM 182330) (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
QA state: New
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Chinnaiyan University of Michigan
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/288
references resource: !/hgnc id/HGNC:25743
references resource: https://www.ncbi.nlm.nih.gov/gene/79570
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/868
type: Biomarker
alias: TRIM22
alias: tripartite motif-containing 22
alias: 50 kDa-stimulated trans-acting factor
alias: GPSTAF50
alias: RING finger protein 94
alias: STAF50
alias: Staf-50
alias: tripartite motif-containing protein 22
alias: stimulated trans-acting factor (50 kDa)
alias: tripartite binding motif 22
alias: Tripartite motif-containing protein 22
alias: E3 ubiquitin-protein ligase TRIM22
alias: tripartite motif containing 22
alias: staf-50
alias: tripartite motif protein TRIM22
alias: RNF94
alias: EC 6.3.2.-
title: TRIM22
hgnc name: TRIM22
URN: urn:edrn:bmdb:biomarker:868
description: From NCBI Gene: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1013
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/10346
references resource: Q8IYM9
references resource: http://omim.org/entry/606559
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/454
type: Biomarker
alias: MIP-4
alias: CC chemokine PARC
alias: AMAC-1
alias: chemokine (C-C), dendritic
alias: MIP4
alias: Macrophage inflammatory protein 4
alias: AMAC1
alias: alternative macrophage activation-associated CC chemokine 1
alias: dendritic cell chemokine 1
alias: CC chemokine ligand 18
alias: Pulmonary and activation-regulated chemokine
alias: PARC
alias: small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
alias: Small-inducible cytokine A18
alias: Alternative macrophage activation-associated CC chemokine 1
alias: pulmonary and activation-regulated chemokine
alias: DC-CK1
alias: Dendritic cell chemokine 1
alias: SCYA18
alias: macrophage inflammatory protein 4
alias: DCCK1
alias: chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
alias: CKb7
alias: small-inducible cytokine A18
alias: small inducible cytokine A18
alias: C-C motif chemokine 18
alias: CCL18
title: CCL18
hgnc name: CCL18
URN: urn:edrn:bmdb:biomarker:454
description: From NCBI Gene: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
references resource: !/hgnc id/HGNC:10616
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P55774
references resource: NP 002979.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/81
type: Biomarker
alias: MIF
alias: GLIF
alias: GIF
alias: macrophage migration inhibitory factor (glycosylation-inhibiting factor)
alias: MMIF
alias: macrophage migration inhibitory factor
alias: phenylpyruvate tautomerase
alias: L-dopachrome tautomerase
alias: L-dopachrome isomerase
alias: Glycosylation-inhibiting factor
title: MIF
hgnc name: MIF
URN: urn:edrn:bmdb:biomarker:81
description: MIF, a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation, plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. MIF is also closely related to tumorigenesis.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/504
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Mor Yale University
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/114
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/254
references resource: !/hgnc id/HGNC:7097
references resource: P14174
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 002406.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1596
type: Biomarker
alias: APOC1
alias: Apolipoprotein C1
alias: Apolipoprotein C-I
alias: Apo-CI
alias: ApoC-I
alias: Apo-CIB
alias: ApoC-IB
title: APOC1
hgnc name: APOC1
URN: urn:edrn:bmdb:biomarker:1596
description: From NCBI Gene: This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]
QA state: New
security: Public
type: Genomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Chinnaiyan University of Michigan
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/288
references resource: !/hgnc id/HGNC:607
references resource: https://www.ncbi.nlm.nih.gov/gene/341
references resource: https://www.genecards.org/cgi-bin/carddisp.pl
references resource: entry

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/63
type: Biomarker
alias: PCA3
alias: prostate cancer antigen 3
alias: DD3
alias: NCRNA00019
alias: non-protein coding RNA 19
alias: prostate cancer antigen 3 (non-protein coding)
alias: prostate cancer associated transcript 3 (non-protein coding)
alias: PCAT3
title: PCA3
hgnc name: PCA3
URN: urn:edrn:bmdb:biomarker:63
description: The prostate cancer antigen 3 (PCA3) gene is a highly specific biomarker upregulated in prostate cancer. Because there is no extensive open reading frame, the gene is thought to express a noncoding RNA. The FDA has approved an assay for prostate cancer that uses the ratio of PCA3 RNA to PSA RNA in urine. The assay is used to help physicians determine the need for repeat prostate biopsies in men 50 years of age or older who have had a previous negative biopsy. When used in conjunction with other clinical information, the use of this test can reduce the need for unnecessary prostate biopsies.
QA state: Curated
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/970
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1075
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Lin UW University of Washington
access granted to: National Cancer Institute
access granted to: Prostate and Urologic
access granted to: Wei University of Michigan
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/95
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/129
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/130
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/140
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/141
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/142
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/188
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/247
references resource: !/hgnc id/HGNC:8637
references resource: http://www.omim.org/entry/604845
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/50652
references resource: ucm294907.htm

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/495
type: Biomarker
alias: TMSB4X
alias: thymosin beta 4, X-linked
alias: TB4X
alias: TMSB4
alias: thymosin, beta 4, X chromosome
alias: T beta-4
alias: PTMB4
alias: FX
alias: prothymosin beta-4
alias: thymosin beta-4
alias: Fx
alias: THYB4
alias: thymosin β4
title: TMSB4X
hgnc name: TMSB4X
URN: urn:edrn:bmdb:biomarker:495
description: TMSB4X, or thymosin beta-4, belongs to the thymosin beta family. It is an actin sequestering protein which plays an important role in the regulation of actin polymerization. TMSB4X binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. It is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/504
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/114
references resource: !/hgnc id/HGNC:11881
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P62328
references resource: NP 066932.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/545
type: Biomarker
alias: SPINK1
alias: Serine Peptidase Inhibitor, Kazal Type 1
alias: PSTI
alias: TATI
alias: PCTT
alias: Spink3
alias: Serine Protease Inhibitor, Kazal Type 1
alias: Serine Protease Inhibitor, Kazal-Type 1
alias: Tumor-Associated Trypsin Inhibitor
alias: TCP
alias: Pancreatic Secretory Trypsin Inhibitor
title: SPINK1
hgnc name: SPINK1
URN: urn:edrn:bmdb:biomarker:545
description: SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Mutations in SPINK1 are associated with hereditary pancreatitis and tropical calcific pancreatitis.
QA state: Curated
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/970
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/129
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/179
references resource: http://www.ncbi.nlm.nih.gov/gene/6690
references resource: !/hgnc id/HGNC:11244
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P00995

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/402
type: Biomarker
alias: ACBP
alias: DBI
alias: diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
alias: ACBD1
alias: endozepine
alias: Acyl-CoA-Binding Protein
alias: Diazepam-Binding Inhibitor
alias: EP
alias: CCK-RP
alias: Cholecystokinin-Releasing Peptide, Trypsin-Sensitive
alias: Endozepine
alias: GABA Receptor Modulator
alias: Acyl-Coenzyme A Binding Domain Containing 1
title: ACBP
hgnc name: DBI
URN: urn:edrn:bmdb:biomarker:402
description: DBI, diazepam binding inhibitor, was previously known as ACBP, acyl-coA binding protein. This protein is regulated by hormones, is involved in lipid metabolism, and is thought to act as a neuropeptide to regulate the action of the GABA receptor. DBI is conserved across species. The most highly conserved domain is the hydrophobic binding site for medium- and long-chain acyl-coA esters. DBI is involved in the regulation of pancreatic secretion and release of cholecystokinin. There are three pseudogenes for DBI on separate chromosomes. DBI has multiple transcript variants encoding different isoforms.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/504
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/114
references resource: http://www.ncbi.nlm.nih.gov/gene/1622
references resource: !/hgnc id/HGNC:2690
references resource: P07108

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1089
type: Biomarker
alias: Ubiquitin
alias: UBB
alias: UBC
alias: UBA52
alias: RPS27A
title: Ubiquitin
URN: urn:edrn:bmdb:biomarker:1089
description: The ubiquitin protein was named due to its ubiquitous presence in the human body. This small protein, comprised of 76 amino acids, is coded for by a family of genes whose translation products are fusion proteins. The four genes that are known to code for ubiquitin are UBB, UBC, UBA52, and RPS27A. Ubiquitin molecules are often bound to other proteins as a marker for degradation. From NCBI Gene: Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/504
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/114
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/240
references resource: http://www.rcsb.org/pdb/101/motm.do
references resource: http://ncit.nci.nih.gov/ncitbrowser/pages/concept_details.jsf

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/427
type: Biomarker
alias: Des-ubiquitin
alias: des-Gly-Gly-ubiquitin
title: Des-ubiquitin
URN: urn:edrn:bmdb:biomarker:427
description: Des-ubiquitin is formed when a cysteine protease cleaves two carboxy-terminal glycine residues from ubiquitin.
QA state: Curated
security: Public
type: Proteomic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/504
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/114
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/241

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1082
type: Biomarker
alias: XRCC5
alias: X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 5 (Double-Strand-Break Rejoining)
alias: Lupus Ku Autoantigen Protein P86
alias: Nuclear Factor IV
alias: Thyroid-Lupus Autoantigen
alias: 86 KDa Subunit Of Ku Antigen
alias: CTC85
alias: CTCBF
alias: Ku86
alias: TLAA
alias: ATP-Dependent DNA Helicase 2 Subunit 2
alias: ATP-Dependent DNA Helicase II 80 KDa Subunit
alias: CTC Box-Binding Factor 85 KDa Subunit
alias: DNA Repair Protein XRCC5
alias: 80kDa
alias: Ku Autoantigen
alias: X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 5 (Double-Strand-Break Rejoining; Ku Autoantigen, 80kD)
alias: KARP-1
alias: KARP1
alias: KU80
alias: KUB2
alias: NFIV
alias: Ku Autoantigen, 80kDa
alias: Ku86 Autoantigen Related Protein 1
alias: X-Ray Repair Cross-Complementing Protein 5
alias: EC 3.6.4.-
alias: G22P2
alias: Ku80
title: XRCC5
hgnc name: XRCC5
URN: urn:edrn:bmdb:biomarker:1082
description: From NCBI Entrez Gene: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/505
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/115
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/7520
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P13010

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1086
type: Biomarker
alias: PMS2L15
alias: Postmeiotic Segregation Increased 2 Pseudogene 7
alias: PMSR7
alias: PMS2LP2
alias: PMS2P7
alias: Postmeiotic Segregation Increased 2-Like Pseudogene 2
alias: Postmeiotic Segregation Increased 2-Like 15
title: PMS2P7
hgnc name: PMS2P7
URN: urn:edrn:bmdb:biomarker:1086
description: PMS2P7, previously known as PMS2L15, was thought to be part of a multigene family found on chromosome bands 7p22, 7p12-p13, 7q11, and 7q22. These genes have since been labeled pseudogenes.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/494
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/133
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/239
references resource: http://www.ncbi.nlm.nih.gov/protein/4239954
references resource: http://www.ncbi.nlm.nih.gov/nuccore/AB017006

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/802
type: Biomarker
alias: RRAGD
alias: bA11D8.2.1
alias: Rag D
alias: Ras-related GTP binding D
alias: DKFZP761H171
alias: Rag D protein
alias: RagD
alias: ras-related GTP-binding protein D
alias: RAGD
title: RRAGD
hgnc name: RRAGD
URN: urn:edrn:bmdb:biomarker:802
description: From NCBI Gene: RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004]
QA state: Curated
phase: 1
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1013
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: http://www.ncbi.nlm.nih.gov/gene/58528
references resource: Q9NQL2
references resource: http://omim.org/entry/608268

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/413
type: Biomarker
alias: CD30 ligand
alias: tumor necrosis factor (ligand) superfamily, member 8
alias: CD30LG
alias: CD30L
alias: CD153
alias: CD30-L
alias: CD153 antigen
alias: CD30 antigen ligand
alias: tumor necrosis factor ligand superfamily member 8
alias: TNFSF8
title: TNFSF8
hgnc name: TNFSF8
URN: urn:edrn:bmdb:biomarker:413
description: TNFSF8, also known as CD30 ligand, is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. TNFSF8 binds to TNFRSF8/CD30, a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. TNFSF8 has been shown to induce proliferation of T-cells. It also enhances cell proliferation of some lymphoma cell lines, and induces cell death and reduces cell proliferation of other lymphoma cell lines. There are two different isoforms encoded by two transcript variants.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/184
references resource: !/hgnc id/HGNC:11938
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P32971
references resource: NP 001235.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/424
type: Biomarker
alias: cyto C
alias: CYCS
alias: Cytochrome C, Somatic
alias: CYC
alias: HCS
alias: THC4
alias: Cytochrome C
title: Cytochrome C
hgnc name: CYCS
URN: urn:edrn:bmdb:biomarker:424
description: CYCS, or cytochrome C, is an electron carrier protein that is an important part of the electron transport chain in mitochondria. The cytochrome C protein is a small heme protein that associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. Cytochrome C also plays a role in apoptosis.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/504
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/114
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/205
references resource: !/hgnc id/HGNC:19986
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P99999
references resource: http://www.ncbi.nlm.nih.gov/gene/54205

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1084
type: Biomarker
alias: BAC clone RP11-499F19
alias: AC108477
alias: GI:23132689
title: BAC clone RP11-499F19
URN: urn:edrn:bmdb:biomarker:1084
description: BAC clone RP11-499F19 is available in Genbank as accession number AC108477. There is no associated protein sequence and no known protein function.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/494
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/505
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/115
references resource: http://www.ncbi.nlm.nih.gov/nuccore/ac108477

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1087
type: Biomarker
alias: EEF1A1
alias: EEF1A
alias: Eukaryotic Translation Elongation Factor 1 Alpha 1
alias: EF1A
alias: LENG7
alias: Leukocyte Receptor Cluster (LRC) Member 7
alias: Elongation Factor Tu
alias: Eukaryotic Elongation Factor 1 A-1
alias: Leukocyte Receptor Cluster Member 7
alias: EF-1-alpha-1
alias: EF-Tu
alias: eEF1A-1
alias: CCS-3
alias: CCS3
alias: EE1A1
alias: EEF-1
alias: GRAF-1EF
alias: HNGC:16303
alias: PTI1
alias: Cervical Cancer Suppressor 3
alias: CTCL Tumor Antigen
alias: EF1a-Like Protein
alias: Elongation Factor 1 Alpha Subunit
alias: Elongation Factor 1-Alpha 1
alias: Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14
alias: Glucocorticoid Receptor AF-1 Specific Elongation Factor
alias: Prostate Tumor-Inducing Protein 1
alias: Translation Elongation Factor 1 Alpha 1-Like 14
title: EEF1A1
hgnc name: EEF1A1
URN: urn:edrn:bmdb:biomarker:1087
description: From NCBI Entrez Gene: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes. [provided by RefSeq, Jul 2008]
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/494
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/133
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/1915
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P68104

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/483
type: Biomarker
alias: RGM-C
alias: hemochromatosis type 2 (juvenile)
alias: HJV
alias: HFE2
alias: RGMC
alias: HFE2A
alias: JH
alias: haemojuvelin
alias: hemojuvelin
alias: Hemochromatosis type 2 protein
alias: RGM domain family member C
alias: repulsive guidance molecule c
title: HFE2
hgnc name: HFE2
URN: urn:edrn:bmdb:biomarker:483
description: HFE2, also known as RGM-C, is a member of the repulsive guidance molecule (RGM) family and is involved in iron metabolism. HFE2 may act as a bone morphogenetic protein (BMP) coreceptor. It is also thought to be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Mutations in the HFE2 gene cause hemochromatosis type 2A, also called juvenile hemochromatosis (JH), an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
references resource: !/hgnc id/HGNC:4887
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: q6zvn8
references resource: NP 998818.1

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/398
type: Biomarker
alias: MIR486-5p
alias: 486-5p
alias: MIR486
alias: MIR-486
alias: hsa-miR-486-5p
title: hsa-miR-486-5p
URN: urn:edrn:bmdb:biomarker:398
description: From NCBI Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
QA state: Curated
security: Public
type: Epigenetic
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/555
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/135
references resource: http://www.microrna.org/microrna/linkFromMirbase.do
references resource: http://www.genenames.org/cgi-bin/gene_symbol_report
references resource: http://www.ncbi.nlm.nih.gov/gene/619554
references resource: http://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/73
type: Biomarker
alias: Transferrin
alias: TF
alias: Serotransferrin
alias: PRO1557
alias: PRO2086
alias: Beta-1 Metal-Binding Globulin
alias: Siderophilin
alias: Epididymis Secretory Sperm Binding Protein Li 71p
alias: HEL-S-71p
alias: TFQTL1
title: TF
hgnc name: TF
URN: urn:edrn:bmdb:biomarker:73
description: TF, or transferrin, a glycoprotein with an approximate molecular weight of 76.5 kDa, is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/547
access granted to: Bast MD Anderson
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/159
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/160
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/162
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: !/hgnc id/HGNC:11740
references resource: P02787
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 001054.1
references resource: http://www.omim.org/entry/190000
references resource: https://www.genecards.org/cgi-bin/carddisp.pl

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/546
type: Biomarker
alias: TFF3
alias: Trefoil Factor 3 (Intestinal)
alias: Polypeptide P1.B
alias: ITF
alias: TFI
alias: HITF
alias: Trefoil Factor 3, HITF, Human Intestinal Trefoil Factor11
alias: P1B
alias: Trefoil Factor 3
alias: HP1.B
alias: Intestinal Trefoil Factor
title: TFF3
hgnc name: TFF3
URN: urn:edrn:bmdb:biomarker:546
description: TFF3 is a member of the trefoil factor family. The trefoil factors are secreted peptides produced by normal intestinal mucosa, characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides.
QA state: Curated
security: Public
type: Gene
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/970
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1594
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/129
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/181
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/182
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/279
references resource: http://www.ncbi.nlm.nih.gov/gene/7033
references resource: !/hgnc id/HGNC:11757
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: Q07654

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/224
type: Biomarker
alias: CEA
alias: CEACAM5
alias: carcinoembryonic antigen-related cell adhesion molecule 5
alias: CD66e
alias: DKFZp781M2392
alias: Carcinoembryonic antigen
alias: Meconium antigen 100
alias: CD66e Antigen
title: CEACAM5
hgnc name: CEACAM5
URN: urn:edrn:bmdb:biomarker:224
description: From NCBI Gene: CEACAM5 is a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. CEACAM5 is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. It is a receptor for E.coli Dr adhesins.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/1076
access granted to: Breast and Gynecologic
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: Liu University of Washington
access granted to: Lokshin University of Pittsburgh Cancer Instititute
access granted to: Lung and Upper Aerodigestive
access granted to: Marks Duke University Medical Center
access granted to: National Cancer Institute
associated dataset: https://edrn-labcas.jpl.nasa.gov/labcas-ui/c/index.html
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/93
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/94
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/99
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/123
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/236
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/244
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/246
references resource: !/hgnc id/HGNC:1817
references resource: P06731
references resource: http://www.genome.jp/dbget-bin/www_bget
references resource: NP 004354.2

http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/479
type: Biomarker
alias: PRKCI
alias: protein kinase C iota type
alias: PRKC-lambda/iota
alias: atypical protein kinase C-lambda/iota
alias: Atypical protein kinase C-lambda/iota
alias: aPKC-lambda/iota
alias: nPKC-iota
alias: DXS1179E
alias: PKCI
alias: protein kinase C, iota
alias: EC 2.7.11.13
title: PRKCI
hgnc name: PRKCI
URN: urn:edrn:bmdb:biomarker:479
description: PRKCI is a member of the protein kinase C (PKC) family of serine/threonine protein kinases. It is a calcium- and diacylglycerol-independent serine/threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis.
QA state: Curated
security: Public
type: Protein
is panel: 0
member of panel: http://edrn.jpl.nasa.gov/bmdb/biomarkers/view/972
access granted to: Crichton JPL
access granted to: Curators
access granted to: Feng Fred Hutchinson Cancer Research Center
access granted to: National Cancer Institute
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/100
referenced in publication: http://edrn.jpl.nasa.gov/bmdb/publications/view/126
references resource: !/hgnc id/HGNC:9404
references resource: http://www.genecards.org/cgi-bin/carddisp.pl
references resource: P41743
references resource: NP 002731.4